Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anisha Korde"'
Autor:
Alexandros Makriyannis, Raymond C. Stevens, Yiran Wu, Kiran Vemuri, Laura M. Bohn, Zhi-Jie Liu, Tian Hua, Travis W. Grim, Robert B. Laprairie, Jo-Hao Ho, Edward L. Stahl, Anisha Korde
Publikováno v:
Molecular Pharmacology. 96:619-628
Cannabinoid receptor 1 (CB1) is a potential therapeutic target for the treatment of pain, obesity and obesity-related metabolic disorders, and addiction. The crystal structure of human CB1 has been determined in complex with the stabilizing antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1dc059e2b5e5833429aa9006413f7e7
https://doi.org/10.1124/mol.119.116483
https://doi.org/10.1124/mol.119.116483
Autor:
Shan Jin, Dianna Lundberg, Brian Dwyer, Weiyi Liu, Sophia Park, Anisha Korde, Clark Pan, Yun-Jung Lee, Bohong Zhang, Omar Quintero Monzon, Roshan M. Padmashali
Publikováno v:
Biotechnology Progress
Antibody‐dependent cellular cytotoxicity (ADCC) is the primary mechanism of actions for several marketed therapeutic antibodies (mAbs) and for many more in clinical trials. The ADCC efficacy is highly dependent on the ability of therapeutic mAbs to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5515872684b4c05fe919b289e49912
http://europepmc.org/articles/PMC7988551
http://europepmc.org/articles/PMC7988551
Autor:
Dianna Lundberg, Sophia Park, Bohong Zhang, Brian Dwyer, Roshan M. Padmashali, Clark Pan, Yun-Jung Lee, Shan Jin, Omar Quintero Monzon, Weiyi Liu, Anisha Korde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6496e1676ce6f8f48809e9b3674da4b6
https://doi.org/10.1002/btpr.3061/v2/response1
https://doi.org/10.1002/btpr.3061/v2/response1
Autor:
Jo-Hao Ho, Spyros P. Nikas, Zhi-Jie Liu, Tian Hua, Yiran Wu, Anisha Korde, Haiguang Liu, Kiran Vemuri, Mengchen Pu, Gye Won Han, Kang Ding, Raymond C. Stevens, Alexandros Makriyannis, Shan Jiang, Xuanxuan Li, Laura M. Bohn, Michael A. Hanson, Suwen Zhao, Robert B. Laprairie, Lu Qu
Publikováno v:
Nature. 547:468-471
Crystal structures of the human cannabinoid receptor 1 (CB1) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor activation, and this flexibility may be a common feature among other G-protein-coupled recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1abe7846e336c006ee8283d9de174651
https://doi.org/10.1038/nature23272
https://doi.org/10.1038/nature23272
Autor:
Anisha Korde, Michelle Glass, David B. Finlay, V. Kiran Vemuri, Morag R. Hunter, Natasha L. Grimsey, Erin E. Cawston, Alexandros Makriyannis
Publikováno v:
British Journal of Pharmacology. 174:2545-2562
BACKGROUND AND PURPOSE CB1 cannabinoid receptor signalling is canonically mediated through inhibitory Gαi proteins, but signalling through other G proteins occurs under some circumstances; Gαs being the most characterised secondary pathway. Determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c705649b33259248751c402a54de29
https://doi.org/10.1111/bph.13866
https://doi.org/10.1111/bph.13866
Autor:
Robert B, Laprairie, Kiran, Vemuri, Edward L, Stahl, Anisha, Korde, Jo-Hao, Ho, Travis W, Grim, Tian, Hua, Yiran, Wu, Raymond C, Stevens, Zhi-Jie, Liu, Alexandros, Makriyannis, Laura M, Bohn
Publikováno v:
Mol Pharmacol
Cannabinoid receptor 1 (CB(1)) is a potential therapeutic target for the treatment of pain, obesity and obesity-related metabolic disorders, and addiction. The crystal structure of human CB(1) has been determined in complex with the stabilizing antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b995b8985b725d9c1ceb42598b4e28f
https://pubmed.ncbi.nlm.nih.gov/31515283
https://pubmed.ncbi.nlm.nih.gov/31515283
Autor:
Eileen M. Denovan-Wright, Nikolai Zvonok, David R. Janero, Alexandros Makriyannis, Han Zhou, Maria Grazia Cascio, Robert B. Laprairie, Ganesh A. Thakur, Ritesh B. Tichkule, Abhijit R. Kulkarni, Anisha Korde, Roger G. Pertwee, Pushkar M. Kulkarni
Publikováno v:
Journal of Medicinal Chemistry
Undesirable side effects associated with orthosteric agonists/antagonists of cannabinoid 1 receptor (CB1R), a tractable target for treating several pathologies affecting humans, have greatly limited their translational potential. Recent discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2376949d8107611d23fb12a81b0c0b
http://europepmc.org/articles/PMC4716578
http://europepmc.org/articles/PMC4716578
Publikováno v:
Methods in enzymology. 593
Detailed characterization of the ligand-binding motifs and structure-function correlates of the principal GPCRs of the endocannabinoid-signaling system, the cannabinoid 1 (CB1R) and cannabinoid 2 (CB2R) receptors, is essential to inform the rational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b9134e9cb73f417868d6635ed858d61
https://pubmed.ncbi.nlm.nih.gov/28750804
https://pubmed.ncbi.nlm.nih.gov/28750804
Autor:
Tian, Hua, Kiran, Vemuri, Spyros P, Nikas, Robert B, Laprairie, Yiran, Wu, Lu, Qu, Mengchen, Pu, Anisha, Korde, Shan, Jiang, Jo-Hao, Ho, Gye Won, Han, Kang, Ding, Xuanxuan, Li, Haiguang, Liu, Michael A, Hanson, Suwen, Zhao, Laura M, Bohn, Alexandros, Makriyannis, Raymond C, Stevens, Zhi-Jie, Liu
Publikováno v:
Nature. 547(7664)
The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ9-tetrahydrocannabinol (Δ9-THC)1. Here we report two agonist-bound crystal structures of human CB1 in complex with a tetrahy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00ed6b768c0cfb689311fec2809062a8
https://pubmed.ncbi.nlm.nih.gov/28678776
https://pubmed.ncbi.nlm.nih.gov/28678776
Detailed characterization of the ligand-binding motifs and structure-function correlates of the principal GPCRs of the endocannabinoid-signaling system, the cannabinoid 1 (CB1R) and cannabinoid 2 (CB2R) receptors, is essential to inform the rational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b08a60c14a993d7695cf6e8565f76b28
https://doi.org/10.1016/bs.mie.2017.06.022
https://doi.org/10.1016/bs.mie.2017.06.022