Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Anis Larbi"'
Autor:
Aarthi Ravikrishnan, Indrik Wijaya, Eileen Png, Kern Rei Chng, Eliza Xin Pei Ho, Amanda Hui Qi Ng, Ahmad Nazri Mohamed Naim, Jean-Sebastien Gounot, Shou Ping Guan, Jasinda Lee Hanqing, Lihuan Guan, Chenhao Li, Jia Yu Koh, Paola Florez de Sessions, Woon-Puay Koh, Lei Feng, Tze Pin Ng, Anis Larbi, Andrea B. Maier, Brian K. Kennedy, Niranjan Nagarajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract While rapid demographic changes in Asia are driving the incidence of chronic aging-related diseases, the limited availability of high-quality in vivo data hampers our ability to understand complex multi-factorial contributions, including gut
Externí odkaz:
https://doaj.org/article/847efc33d26e47edb08e63e509b16783
Autor:
Mohammad Amin Honardoost, Andreas Adinatha, Florian Schmidt, Bobby Ranjan, Maryam Ghaeidamini, Nirmala Arul Rayan, Michelle Gek Liang Lim, Ignasius Joanito, Quy Xiao Xuan Lin, Deepa Rajagopalan, Shi Qi Mok, You Yi Hwang, Anis Larbi, Chiea Chuen Khor, Roger Foo, Bernhard Otto Boehm, Shyam Prabhakar
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease resulting from an immune-mediated destruction of pancreatic insulin-secreting $$\beta$$ β cells. A comprehensive immune cell phenotype evaluation in T1D
Externí odkaz:
https://doaj.org/article/c994264bbf6c46a98457293f3fbf1308
Autor:
Anis Larbi
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1469 (2024)
The immune system is a highly complex and tightly regulated system that plays a crucial role in protecting the body against external threats, such as pathogens, and internal abnormalities, like cancer cells. It undergoes development during fetal stag
Externí odkaz:
https://doaj.org/article/9730d640dc264378a04082889d0063ff
Autor:
Elin Synnøve Røyset, Henrik P Sahlin Pettersen, Weili Xu, Anis Larbi, Arne K Sandvik, Sonja E Steigen, Ignacio Catalan‐Serra, Ingunn Bakke
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 1, Pp 18-31 (2023)
Abstract Colon mucosae of ulcerative colitis (UC) and Crohn's disease (CD) display differences in the number and distribution of immune cells that are difficult to assess by eye. Deep learning‐based analysis on whole slide images (WSIs) allows extr
Externí odkaz:
https://doaj.org/article/50ead8b7e1914159a0fc47294967fc30
Autor:
Yanxia Lu, Wee Shiong Lim, Xia Jin, Ma Schwe Zin Nyunt, Tamas Fulop, Qi Gao, Su Chi Lim, Anis Larbi, Tze Pin Ng
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundSarcopenia is common among older individuals with and without type 2 diabetes mellitus (T2DM). There are conflicting evidence in support of the role of insulin in the development of age-related and T2DM-related sarcopenia. We investigated t
Externí odkaz:
https://doaj.org/article/849df1db159c410a95f05fa126d1bc3a
Autor:
Usma Munawara, Michael Catanzaro, Weili Xu, Crystal Tan, Katsuiku Hirokawa, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque, Charles Ramassamy, Annelise E. Barron, Stephen Cunnane, Pascale B. Beauregard, Jean-Pierre Bellenger, Serafim Rodrigues, Mathieu Desroches, Jacek M. Witkowski, Benoit Laurent, Eric H. Frost, Tamas Fulop
Publikováno v:
Immunity & Ageing, Vol 18, Iss 1, Pp 1-25 (2021)
Abstract Background Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related to systemic inflam
Externí odkaz:
https://doaj.org/article/6261844794f64438bcf02c6bb6efef09
Autor:
Marie Strickland, Salanne Lee, Shi Yong Neo, Akhila Balachander, Ivy Low, Seri Mustafah, Wah Ing Goh, Graham D. Wright, Anis Larbi, Sylvia L. F. Pender
Publikováno v:
Biology, Vol 12, Iss 4, p 597 (2023)
Human ageing is accompanied by poor responses to infection and decreased vaccine efficacy. While the causes of this can be attributed to defects in the immune system that increase with age, it is unknown whether mitochondrial dysfunction may also con
Externí odkaz:
https://doaj.org/article/f008b7fea35744af944fc354145a444d
Autor:
Julia Böhme, Nuria Martinez, Shamin Li, Andrea Lee, Mardiana Marzuki, Anteneh Mehari Tizazu, David Ackart, Jessica Haugen Frenkel, Alexandra Todd, Ekta Lachmandas, Josephine Lum, Foo Shihui, Tze Pin Ng, Bernett Lee, Anis Larbi, Mihai G. Netea, Randall Basaraba, Reinout van Crevel, Evan Newell, Hardy Kornfeld, Amit Singhal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Metformin is an anti-diabetic drug that has shown promise to reduce M. tuberculosis susceptibility. Here the authors show that this effect is a result of metformin-mediated activation of anti-mycobacterial memory-like antigen-inexperienced CD8+CXCR3+
Externí odkaz:
https://doaj.org/article/c3eaedfff37a462ea0ead94e00336a91
Autor:
Guillaume Carissimo, Weili Xu, Immanuel Kwok, Mohammad Yazid Abdad, Yi-Hao Chan, Siew-Wai Fong, Kia Joo Puan, Cheryl Yi-Pin Lee, Nicholas Kim-Wah Yeo, Siti Naqiah Amrun, Rhonda Sin-Ling Chee, Wilson How, Stephrene Chan, Bingwen Eugene Fan, Anand Kumar Andiappan, Bernett Lee, Olaf Rötzschke, Barnaby Edward Young, Yee-Sin Leo, David Chien Lye, Laurent Renia, Lai Guan Ng, Anis Larbi, Lisa FP Ng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-
Externí odkaz:
https://doaj.org/article/d967340f6639442885027de8b53a2e43
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
Autor:
Hassen Kared, Shu Wen Tan, Mai Chan Lau, Marion Chevrier, Crystal Tan, Wilson How, Glenn Wong, Marie Strickland, Benoit Malleret, Amanda Amoah, Karolina Pilipow, Veronica Zanon, Naomi Mc Govern, Josephine Lum, Jin Miao Chen, Bernett Lee, Maria Carolina Florian, Hartmut Geiger, Florent Ginhoux, Ezequiel Ruiz-Mateos, Tamas Fulop, Reena Rajasuriar, Adeeba Kamarulzaman, Tze Pin Ng, Enrico Lugli, Anis Larbi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Aging is associated with immune attrition that may impact the effectiveness of the immune system to protect the host from pathogens. Here the authors show that immune aging is associated with alterations in the Wnt/β-catenin signaling and reduced st
Externí odkaz:
https://doaj.org/article/d05913b802064e6bbba5a639e2f712a7