Cholesterol Interaction Directly Enhances Intrinsic Activity of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Autor: Stephanie Chin, Mohabir Ramjeesingh, Maurita Hung, June Ereño-Oreba, Hong Cui, Onofrio Laselva, Jean-Philippe Julien, Christine E. Bear

Publikováno v: Cells, Vol 8, Iss 8, p 804 (2019)

The recent cryo-electron microscopy structures of zebrafish and the human cystic fibrosis transmembrane conductance regulator (CFTR) provided unprecedented insights into putative mechanisms underlying gating of its anion channel activity. Interesting

Externí odkaz: https://doaj.org/article/1f1cefb53ced4f29a9b93238e1506a92

Organoids as a Model for Intestinal Ion Transport Physiology

Autor: de Jonge, Hugo, Bijvelds, Marcel, Strubberg, Ashlee M., Liu, Jinghua, Clarke, Lane L., Hamilton, Kirk L., Devor, Daniel C.

Publikováno v: Ion Transport Across Epithelial Tissues and Disease: Ion Channels and Transporters of Epithelia in Health and Disease, 2(2), 1-39
Ion Transport Across Epithelial Tissues and Disease ISBN: 9783030553098

The advent of intestinal organoid culture in 2009 was a fortuitous development in the search for a valid marker of intestinal stem cells, and provided proof of murine intestinal stem cell regenerative potential. Intestinal organoid culture was preced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960ca796a29bcdeb74f8bc41b882e1fa
https://doi.org/10.1007/978-3-030-55310-4_1

ORKAMBI-Mediated Rescue of Mucociliary Clearance in Cystic Fibrosis Primary Respiratory Cultures Is Enhanced by Arginine Uptake, Arginase Inhibition, and Promotion of Nitric Oxide Signaling to the Cystic Fibrosis Transmembrane Conductance Regulator Channel

Autor: Sunny Xia, Theo J. Moraes, Claire Bartlett, Janet Jiang, Leigh Wellhauser, Tanja Gonska, Yu-Sheng Wu, Hong Ouyang, Onofrio Laselva, Alexandria Lew, Wan Ip, Christine E. Bear, Saumel Ahmadi

Publikováno v: Molecular Pharmacology. 96:515-525

ORKAMBI, a combination of the corrector, lumacaftor, and the potentiator, ivacaftor, partially rescues the defective processing and anion channel activity conferred by the major cystic fibrosis-causing mutation, F508del, in in vitro studies. Clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5243a55b077b06eb706b6c9c65c40c1e
https://doi.org/10.1124/mol.119.117143

Biphasic activation of survival and death pathways in Arabidopsis thaliana cultured cells by sorbitol-induced hyperosmotic stress

Autor: Aurélien Dauphin, Patrice Meimoun, Patrick Laurenti, Takashi Kadono, Sylvie Cangémi, Rafik Errakhi, David Reboutier, Stefano Mancuso, Emanuela Monetti, Arnaud Lehner, Hayat El-Maarouf-Bouteau, François Bouteau, Tingting Zhao, Daniel Tran, Delphine Arbelet-Bonnin, Tomonori Kawano

Publikováno v: Plant Science
Plant Science, Elsevier, 2021, pp.110844
HAL

Hyperosmotic stresses represent some of the most serious abiotic factors that adversely affect plants growth, development and fitness. Despite their central role, the early cellular events that lead to plant adaptive responses remain largely unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f58fddf01f824667be603849aa5c330
https://hal-normandie-univ.archives-ouvertes.fr/hal-03141163

Identification of SLAC1 anion channel residues required for CO 2 /bicarbonate sensing and regulation of stomatal movements

Autor: J. Andrew McCammon, Jingbo Zhang, Julian I. Schroeder, Felix Hauser, Nuo Wang, Yinglong Miao, Wouter-Jan Rappel

Publikováno v: Proceedings of the National Academy of Sciences. 115:11129-11137

Increases in CO2 concentration in plant leaves due to respiration in the dark and the continuing atmospheric [CO2] rise cause closing of stomatal pores, thus affecting plant–water relations globally. However, the underlying CO2/bicarbonate (CO2/HCO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4725861e54ad1f9ed87b4ba2a9ba6f24
https://doi.org/10.1073/pnas.1807624115