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pro vyhledávání: '"Anina Niederer"'
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S. Smith, Ralf Strohner, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
G protein-coupled receptors are a major class of drug targets. Here, the authors develop a method whereby their biophysical and functional properties can be altered through directed evolution in mammalian cells, leading to variants exhibiting feature
Externí odkaz:
https://doaj.org/article/b76be3cffcda479f9ff2db12a5dfd09a
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest Smith, Ralf Strohner, Andreas Plückthun
Low stability and poor expression levels are inherent in many G protein-coupled receptors, hindering structural and biophysical analyses. Directed evolution in bacterial or yeast display systems has been successfully used to overcome both limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdab7895d213120ed492900825cbe37
https://doi.org/10.1101/2022.10.17.512578
https://doi.org/10.1101/2022.10.17.512578
