Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Animesh Goswami"'
Publikováno v:
Services and Business Process Reengineering ISBN: 9789811586200
The early detection of epidemics is crucial in their containment and prevention, especially in rural areas where the healthcare infrastructure as well as physical connectivity to the outside world are mostly inadequate and limited. So to tackle such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aab6c98f9b53b98a084a53735feb843
https://doi.org/10.1007/978-981-15-8621-7_4
https://doi.org/10.1007/978-981-15-8621-7_4
Autor:
Alaric J. Dyckman, Bang-Chi Chen, Percy H. Carter, Zhiwei Guo, Amarjit Singh, John L. Gilmore, James E. Sheppeck, Animesh Goswami, Huiping Zhang, Xiaoping Hou, Arvind Mathur
Publikováno v:
Organic Process Research & Development. 21:200-207
This article presents a stereospecific scale-up synthesis of (S)-1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidine-3-carboxylic acid (BMS-960), a potent and selective isoxazole-containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f03408f0071ceb43a9b68457e03ff50
https://doi.org/10.1021/acs.oprd.6b00366
https://doi.org/10.1021/acs.oprd.6b00366
Autor:
Zhiwei Guo, Animesh Goswami, Ronald L. Hanson, Francisco González-Bobes, Michaël D. B. Fenster
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 133:20-26
Racemic α-substituted ketones were converted to the corresponding chiral alcohols with high diastereo- and enantioselectivities using enzymatic reduction with concomitant dynamic kinetic resolution. Reductions of N-protected α-amino ketones by micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e637c448ab77fd89b0898fcc6121bf58
https://doi.org/10.1016/j.molcatb.2016.07.008
https://doi.org/10.1016/j.molcatb.2016.07.008
Publikováno v:
Advanced Synthesis & Catalysis. 358:2077-2082
The concise synthesis of a pharmaceutical candidate is described. The chiral core of the molecule is assembled using an aza-benzoin condensation and a dynamic kinetic resolution (DKR) as the key reactions. This enables superb control of the regio-, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0920245148baa9472eaac2959a33400c
https://doi.org/10.1002/adsc.201600329
https://doi.org/10.1002/adsc.201600329
Autor:
Animesh Goswami, Andrew S. Wells, David Entwistle, Nicholas J. Turner, Robert K. Sato, Wong John Wing, Stefan Mix, Keith R. Fandrick, Thomas S. Moody, Timothy James-Norman Watson, Peter C. Michels, Long Pang, Gregory L. Finch, Heewon Lee
Publikováno v:
Organic Process Research & Development. 20:594-601
Biocatalysis is essentially the use of enzymes to perform chemical transformations on organic compounds and has been exploited for applications in various industries including food, fine chemicals, agrochemicals, and pharmaceuticals. Due to their sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e3b888bef530886f8f1d5547c74b23
https://doi.org/10.1021/acs.oprd.5b00369
https://doi.org/10.1021/acs.oprd.5b00369
Autor:
Rossano Lucius T, Michael A. Schmidt, Vu Chi Truc, Jacob Albrecht, Andrew G. Lee, Xinhua Qian, Ehrlic Lo, Steven L. Goldberg, Emily A. Reiff, Jaan A. Pesti, Chao Hang, Kenneth J. Natalie, Animesh Goswami, Zhiwei Guo, Chenchi Wang
Publikováno v:
Organic Process Research & Development. 19:1317-1322
The process development and large scale synthesis for the β-hydroxyamino amide 1 is described. The route evolved from a multistep sequence utilizing a classical resolution to a two-step enantioselective process involving an enzyme-catalyzed aldol re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78e620e78b1f8852562c1c09f2eda3c
https://doi.org/10.1021/acs.oprd.5b00192
https://doi.org/10.1021/acs.oprd.5b00192
Autor:
Zhiwei Guo, Animesh Goswami, Steven L. Goldberg, Kenneth J. Natalie, Vu Chi Truc, Chao Hang, Rossano Lucius T, Michael A. Schmidt, Andrew G. Lee, Ehrlic Lo, Yeung Y. Chan
Publikováno v:
Organic Process Research & Development. 19:1308-1316
The chiral β-hydroxy-α-amino acid, (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-propanoic acid, is a key intermediate in the synthesis of the API (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-1-(pyrrolidin-1-yl)propan-1-one, a developmental drug candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb02e24fc17ba2492c2cb3e297aff494
https://doi.org/10.1021/acs.oprd.5b00191
https://doi.org/10.1021/acs.oprd.5b00191
Publikováno v:
Organic Process Research & Development. 19:819-830
Lipase PS 30 (immobilized on polypropylene) from Pseudomonas cepacia was used for enantioselective esterification of (RS)-1-(2-fluoro-4-iodophenyl)-3-hydroxypyrrolidin-2-one by using succinic anhydride and 2-methyltetrahydrofuran at 4 °C. The isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d524482a2bdbfb4416e2aa38cde4b0
https://doi.org/10.1021/acs.oprd.5b00084
https://doi.org/10.1021/acs.oprd.5b00084
Autor:
Animesh Goswami, Feng Qiu, Carl P. Decicco, Andrew T. Pudzianowski, Quentin Michaudel, Adrienne A. Tymiak, Patrick Y.S. Lam, Samuel J. Bonacorsi, Yingru Zhang, Benjamin P. Vokits, Bei Wang, Brad D. Maxwell, Bang-Chi Chen, Ronald L. Hanson, Jun Dai, Arvind Mathur, Dauh-Rurng Wu, Scott A. Shaw, W. Griffith Humphreys, Shun Su, Phil S. Baran, Janet Caceres Cortes, Balu Balasubramanian, Ruth R. Wexler, Zhiwei Guo, Rulin Zhao, Dawn Sun, Wenying Li, Li Peng, Kevin Cao
Publikováno v:
The Journal of Organic Chemistry. 80:7019-7032
Clopidogrel is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y12 and thus inhibit platelet activation. However, gaining an understanding of patient response has been limited due to imprecise und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c53ac4952f4eca4144d5c86041f3bba
https://doi.org/10.1021/acs.joc.5b00632
https://doi.org/10.1021/acs.joc.5b00632
Autor:
Xiaohua Stella Huang, Alicia Regueiro-Ren, Jacob Swidorski, Zhiwei Guo, Animesh Goswami, Frank Rinaldi, Thomas P. Tully
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 117:45-53
Enzymatic transformation of betulinic acid by growing cells of microorganisms provided several hydroxylated and oxidized products. Bacillus megaterium SC16644 gave 7β,15α-dihydroxybetulinic acid, 7β,15α-dihydroxybetulonic acid, and a new compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb140a1f126000158b4560c9b5150a6
https://doi.org/10.1016/j.molcatb.2015.04.012
https://doi.org/10.1016/j.molcatb.2015.04.012