Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Anilkumar Gopalakrishnapillai"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 201-209 (2020)
Approximately 1%–2% of children with Down syndrome (DS) develop acute myeloid leukemia (AML) prior to age 5 years. AML in DS children (ML-DS) is characterized by the pathognomonic mutation in the gene encoding the essential hematopoietic transcript
Externí odkaz:
https://doaj.org/article/fd5d0a78aaea465fbb4034ac1d82ed03
Autor:
Erin L. Crowgey, Nitin Mahajan, Wing Hing Wong, Anilkumar Gopalakrishnapillai, Sonali P. Barwe, E. Anders Kolb, Todd E. Druley
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Background Pediatric leukemias have a diverse genomic landscape associated with complex structural variants, including gene fusions, insertions and deletions, and single nucleotide variants. Routine karyotype and fluorescence in situ hybridi
Externí odkaz:
https://doaj.org/article/029a6cb2db584381a88e47b62bf2432e
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The development of resistance to anti-cancer therapeutics remains one of the core issues preventing the improvement of survival rates in cancer. Therapy resistance can arise in a multitude of ways, including the accumulation of epigenetic alterations
Externí odkaz:
https://doaj.org/article/f6067a25ee984f53a13a4855a7821e9e
Autor:
Sonali P. Barwe, Aimy Sebastian, Ishnoor Sidhu, Edward Anders Kolb, Anilkumar Gopalakrishnapillai
Publikováno v:
Cells, Vol 11, Iss 4, p 628 (2022)
Children with Down syndrome (DS) have a high risk for acute myeloid leukemia (DS-ML). Genomic characterization of DS-ML blasts showed the presence of unique mutations in GATA1, an essential hematopoietic transcription factor, leading to the productio
Externí odkaz:
https://doaj.org/article/696c6a1019cc4fc9bc630ffb07008618
Publikováno v:
Cells, Vol 10, Iss 10, p 2698 (2021)
In vitro modeling of hematological malignancies not only provides insights into the influence of genetic aberrations on cellular and molecular mechanisms involved in disease progression but also aids development and evaluation of therapeutic agents.
Externí odkaz:
https://doaj.org/article/68059fe3fd6540b0a3a0bb6bee662a83
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 288-298 (2017)
Using a CRISPR/Cas9 system, we have reengineered a translational start site in the GATA1 gene in K562 cells. This mutation accounts largely for the onset of myeloid leukemia in Down syndrome (ML-DS). For this reengineering, we utilized CRISPR/Cas9 to
Externí odkaz:
https://doaj.org/article/862e8a7a8bf645a4bd59778c5f829f8a
Autor:
Anilkumar Gopalakrishnapillai, E Anders Kolb, Priyanka Dhanan, Robert W Mason, Andrew Napper, Sonali P Barwe
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140564 (2015)
The bone marrow microenvironment plays an important role in acute lymphoblastic leukemia (ALL) cell proliferation, maintenance, and resistance to chemotherapy. Annexin II (ANX2) is abundantly expressed on bone marrow cells and complexes with p11 to f
Externí odkaz:
https://doaj.org/article/d16a660fbf7a468bb2b7211dcf127bb0
Publikováno v:
Cancers; Volume 15; Issue 12; Pages: 3112
Advances in therapies of pediatric acute myeloid leukemia (AML) have been minimal in recent decades. Although 82% of patients will have an initial remission after intensive therapy, approximately 40% will relapse. KMT2A is the most common chromosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::777231ae13e40b2b8143697ca082d401
Autor:
Anilkumar Gopalakrishnapillai, Todd A. Alonzo, Soheil Meshinchi, Min Xu, Steven M. Kornblau, Lisa Broderson, E. Anders Kolb, Timothy J. Triche, Jenny L. Smith, Sonali P. Barwe, Quy Le, Michael R. Loken, Amanda R. Leonti, Colin Correnti, Laura Pardo, Cassie K. Chou, Robert B. Gerbing, Allison Kaeding, Rhonda E. Ries, Katherine Tarlock, Thao T. Tang
Publikováno v:
Blood Adv
In an effort to identify acute myeloid leukemia (AML)-restricted targets for therapeutic development in AML, we analyzed the transcriptomes of 2051 children and young adults with AML and compared the expression profile with normal marrow specimens. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbabf29991c7fc5db37a55aa3acac84
https://doi.org/10.1182/bloodadvances.2021004424
https://doi.org/10.1182/bloodadvances.2021004424
Autor:
Ishnoor Sidhu, Sonali P. Barwe, Kristi Lynn Kiick, E. Anders Kolb, Anilkumar Gopalakrishnapillai
Publikováno v:
Blood. 140:8805-8806
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c9961cb53ddf6d357482e5b412f0443
https://doi.org/10.1182/blood-2022-170637
https://doi.org/10.1182/blood-2022-170637