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Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study

Autor: Hannah R Elliott, Anila Syed, Peter M. Rothwell, Patrick F. Chinnery

Publikováno v: Lancet Neurology

Summary Background Genetic factors have a role in the pathogenesis of ischaemic stroke, but the main genes involved have yet to be defined. Mitochondrial mechanisms have been implicated in the pathophysiology of acute stroke, but the role of mitochon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87933843083854a853c70618f5bed49b
https://doi.org/10.1016/s1474-4422(10)70083-1

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Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease

Autor: Diane J. Nugent, Anila Syed, Thomas J. Kunicki, Shirley A. Williams, Peter M. Rothwell, Paul Harrison, Helen Segal

Publikováno v: Thrombosis and Haemostasis. 101:123-133

SummaryWe studied the effect of prophylactic aspirin (ASA) ingestion on platelet function in 463 patients with stroke, transient ischemic attack (TIA) or acute coronary disease (ACD), using the Platelet Function Analyzer-100 (PFA-100). We correlated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd422a983295433962781a46c027fb83
https://doi.org/10.1160/th08-05-0287

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Lack of reproducibility of assessment of aspirin responsiveness by optical aggregometry and two platelet function tests

Autor: Paul Harrison, Helen Segal, Fiona C. Cuthbertson, Anila Syed, Louise E. Silver, Peter M. Rothwell

Publikováno v: Platelets. 19:119-124

The term aspirin-resistance describes the failure of aspirin to inhibit thromboxane A(2) production. Many new tests have become available for potentially measuring aspirin responses but some are non-specific and do not isolate COX-1 activity. We prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67dfd007b7827bc109e905dffdb103c
https://doi.org/10.1080/09537100701771736

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Lack of association between aspirin responsiveness and seven candidate gene haplotypes in patients with symptomatic vascular disease

Autor: Thomas J, Kunicki, Shirley A, Williams, Diane J, Nugent, Paul, Harrison, Helen C, Segal, Anila, Syed, Peter M, Rothwell

Publikováno v: Thrombosis and haemostasis. 101(1)

We studied the effect of prophylactic aspirin (ASA) ingestion on platelet function in 463 patients with stroke, transient ischemic attack (TIA) or acute coronary disease (ACD), using the Platelet Function Analyzer-100 (PFA-100). We correlated ASA res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55e3fbe7cfe07196677f1f883b6041b3
https://pubmed.ncbi.nlm.nih.gov/19132198

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Histological features of symptomatic carotid plaques in patients with impaired glucose tolerance and diabetes (oxford plaque study)

Autor: Anila Syed, Jessica Redgrave, J K Lovett, Peter M. Rothwell

Publikováno v: Cerebrovascular diseases (Basel, Switzerland). 26(1)

Background: Diabetes is associated with an increased risk of incident stroke and both early and late recurrent stroke after transient ischaemic attack. Some small studies have suggested that atherosclerotic plaques from diabetics have a higher preval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4d394fbcdfa51242955c8b3c05fa34
https://pubmed.ncbi.nlm.nih.gov/18535373

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