Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Anila George"'
Autor:
Anila George, Poornasree Sadanandan, Nithin Sam Ravi, B. Vaishnavi, Srujan Marepally, Saravanbhavan Thangavel, Shaji R. Velayudhan, Alok Srivastava, Kumarasamypet M Mohankumar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102347- (2024)
Recent studies have shown that base editing, even with single-strand breaks, could result in large deletions of the interstitial regions while targeting homologous regions. Several therapeutically relevant genes such as HBG, HBB, CCR5, and CD33 have
Externí odkaz:
https://doaj.org/article/16c6ab9d93df4d0791d211dc6272b842
Autor:
Kirti Prasad, Nivedhitha Devaraju, Anila George, Nithin Sam Ravi, Joshua Paul, Gokulnath Mahalingam, Vignesh Rajendiran, Lokesh Panigrahi, Vigneshwaran Venkatesan, Kartik Lakhotiya, Yogapriya Periyasami, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Shaji R. Velayudhan, Gregory A. Newby, Srujan Marepally, Alok Srivastava, Kumarasamypet M. Mohankumar
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102205- (2024)
β-thalassemia/HbE results from mutations in the β-globin locus that impede the production of functional adult hemoglobin. Base editors (BEs) could facilitate the correction of the point mutations with minimal or no indel creation, but its efficienc
Externí odkaz:
https://doaj.org/article/1c5f0f013cfe4f2da711f4e85aae51fa
Autor:
Krittika Nandy, Dinesh Babu, Sonam Rani, Gaurav Joshi, Smitha Ijee, Anila George, Dhavapriya Palani, Chitra Premkumar, Praveena Rajesh, S. Vijayanand, Ernest David, Mohankumar Murugesan, Shaji R. Velayudhan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The preferred method for disease modeling using induced pluripotent stem cells (iPSCs) is to generate isogenic cell lines by correcting or introducing pathogenic mutations. Base editing enables the precise installation of point mutations at
Externí odkaz:
https://doaj.org/article/4eb22e023f824b6291ae6cf0baa45693
Efficient and error-free correction of sickle mutation in human erythroid cells using prime editor-2
Autor:
Anila George, Nithin Sam Ravi, Kirti Prasad, Lokesh Panigrahi, Sanya Koikkara, Vignesh Rajendiran, Nivedhitha Devaraju, Joshua Paul, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R. Velayudhan, Alok Srivastava, Kumarasamypet M. Mohankumar
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2022)
Sickle cell anaemia (SCA) is one of the common autosomal recessive monogenic disorders, caused by a transverse point mutation (GAG > GTG) at the sixth codon of the beta-globin gene, which results in haemolytic anaemia due to the fragile RBCs. Recent
Externí odkaz:
https://doaj.org/article/5c7fcda3597440939586146c2d46906f
Autor:
Nithin Sam Ravi, Beeke Wienert, Stacia K Wyman, Henry William Bell, Anila George, Gokulnath Mahalingam, Jonathan T Vu, Kirti Prasad, Bhanu Prasad Bandlamudi, Nivedhitha Devaraju, Vignesh Rajendiran, Nazar Syedbasha, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Muthuraman Narayanasamy, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R Velayudhan, Alok Srivastava, Mark A DeWitt, Merlin Crossley, Jacob E Corn, Kumarasamypet M Mohankumar
Publikováno v:
eLife, Vol 11 (2022)
Naturally occurring point mutations in the HBG promoter switch hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin in sickle cell patients with hereditary persistence of fetal hemoglobin (HPFH) and ameliorate the clinical seve
Externí odkaz:
https://doaj.org/article/4e7c9ae5baf449a09c47d7d306218410
Publikováno v:
Environmental Monitoring and Assessment. 195
The present study was intended for assessing the contamination level of various heavy metals in surface soil and groundwater around the automobile workshops situated at different locations in the Kollam District of Kerala state, India. The procured s
Autor:
Najila Nizar, Anila George
Publikováno v:
Research Journal of Chemistry and Environment. 26:90-96
The current research was carried out to estimate the concentration of heavy metals in water and aquatic macrophytes (Hydrilla verticillata, Salvinia minima and Eichornia crassipes) collected from the Polachira wetland of Kollam district, Kerala durin
Publikováno v:
Saudi Medical Journal. 42:825-831
Objectives: To assess the utility of ferritin and inflammatory biomarkers in the diagnosis of stages of breast cancer. Methods: The study consisted of 4 groups of 20 women, including the healthy control. The patients of group 1 comprised of stages I
Autor:
Kirti Prasad, Nivedhitha Devaraju, Anila George, Nithin Sam Ravi, Gokulnath Mahalingam, Vignesh Rajendiran, Lokesh Panigrahi, Vigneshwaran Venkatesan, Kartik Lakhotiya, Yogapriya Moorthy, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Shaji R Velayudhan, Srujan Marepally, Alok Srivastava, Kumarasamypet M Mohankumar
β-thalassemia and HbE result from mutations in the β-globin locus that impedes the production of functional β-hemoglobin and represents one of the most common genetic disorders worldwide. Recent advances in genome engineering have opened up new th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e4cd3c8318f2001c9d7e4914d6c62f
https://doi.org/10.1101/2022.06.01.494256
https://doi.org/10.1101/2022.06.01.494256
Autor:
Nithin Sam Ravi, Beeke Wienert, Stacia K Wyman, Henry William Bell, Anila George, Gokulnath Mahalingam, Jonathan T Vu, Kirti Prasad, Bhanu Prasad Bandlamudi, Nivedhitha Devaraju, Vignesh Rajendiran, Nazar Syedbasha, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Muthuraman Narayanasamy, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R Velayudhan, Alok Srivastava, Mark A DeWitt, Merlin Crossley, Jacob E Corn, Kumarasamypet M Mohankumar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10cdfe121f2613584ecf0e1f49c26c47
https://doi.org/10.7554/elife.65421.sa2
https://doi.org/10.7554/elife.65421.sa2