Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anil Pahuja"'
Autor:
Arjun Khunger, Ghanashyam Sarikonda, Jennifer Tsau, Anil Pahuja, Zeni Alfonso, Jane Gao, Christian Laing, Christine Vaupel, Naveen Dakappagari, Ahmad A. Tarhini
Publikováno v:
Translational Oncology, Vol 14, Iss 3, Pp 101014- (2021)
Neoadjuvant therapy with ipilimumab in combination with high dose IFNα was evaluated in patients with locally/regionally advanced melanoma in a previously reported clinical trial [NCT01608594]. In this study, peripheral immune cell profiling was per
Externí odkaz:
https://doaj.org/article/099a2088a9b64bcebb0642fdaabb7971
Autor:
Ahmad A. Tarhini, John M. Kirkwood, Hassane M. Zarour, Amy Rose, Cindy Sander, Matthew P. Holtzman, James F. Pingpank, Christian Laing, Zeni Alfonso, Jennifer Tsau, Anil Pahuja, Ghanashyam Sarikonda, Beiru Chen, Ju Young Kim, Jehovana O. Bender, IlaSri B. Summit, Jennifer Bordeaux, Joseph J. Skitzki, Igor Puzanov, Marc S. Ernstoff, Lisa H. Butterfield, Rogerio I. Neves, Joseph J. Drabick, Arivarasan Karunamurthy, Diwakar Davar, Yan Zang, Yan Lin, Huang Lin, Dustin McCurry, Yana G. Najjar
Treatment significantly affects the circulating immune compartment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eeb4ff31ce1f39f892e656546912333
https://doi.org/10.1158/1078-0432.22481585
https://doi.org/10.1158/1078-0432.22481585
Autor:
Ahmad A. Tarhini, John M. Kirkwood, Hassane M. Zarour, Amy Rose, Cindy Sander, Matthew P. Holtzman, James F. Pingpank, Christian Laing, Zeni Alfonso, Jennifer Tsau, Anil Pahuja, Ghanashyam Sarikonda, Beiru Chen, Ju Young Kim, Jehovana O. Bender, IlaSri B. Summit, Jennifer Bordeaux, Joseph J. Skitzki, Igor Puzanov, Marc S. Ernstoff, Lisa H. Butterfield, Rogerio I. Neves, Joseph J. Drabick, Arivarasan Karunamurthy, Diwakar Davar, Yan Zang, Yan Lin, Huang Lin, Dustin McCurry, Yana G. Najjar
Representative gating strategy illustrating (A) CD4 and CD8 T cell identification (B) expression of ICOS on CD4 positive T cells (C) expression of PD-1 and Ki-67 within PD-1 positive cells and (D) expression of CD38/HLA-DR, PD-1 and KI-67 within CD8+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05be2d07b58f4dfd685805c3833c030c
https://doi.org/10.1158/1078-0432.22481579.v1
https://doi.org/10.1158/1078-0432.22481579.v1
Autor:
Ahmad A. Tarhini, John M. Kirkwood, Hassane M. Zarour, Amy Rose, Cindy Sander, Matthew P. Holtzman, James F. Pingpank, Christian Laing, Zeni Alfonso, Jennifer Tsau, Anil Pahuja, Ghanashyam Sarikonda, Beiru Chen, Ju Young Kim, Jehovana O. Bender, IlaSri B. Summit, Jennifer Bordeaux, Joseph J. Skitzki, Igor Puzanov, Marc S. Ernstoff, Lisa H. Butterfield, Rogerio I. Neves, Joseph J. Drabick, Arivarasan Karunamurthy, Diwakar Davar, Yan Zang, Yan Lin, Huang Lin, Dustin McCurry, Yana G. Najjar
Treatment significantly affects the circulating immune compartment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf8661283efc187904b5f5fcda67641
https://doi.org/10.1158/1078-0432.22481576.v1
https://doi.org/10.1158/1078-0432.22481576.v1
Data from Neoadjuvant Pembrolizumab and High-Dose IFNα-2b in Resectable Regionally Advanced Melanoma
Autor:
Ahmad A. Tarhini, John M. Kirkwood, Hassane M. Zarour, Amy Rose, Cindy Sander, Matthew P. Holtzman, James F. Pingpank, Christian Laing, Zeni Alfonso, Jennifer Tsau, Anil Pahuja, Ghanashyam Sarikonda, Beiru Chen, Ju Young Kim, Jehovana O. Bender, IlaSri B. Summit, Jennifer Bordeaux, Joseph J. Skitzki, Igor Puzanov, Marc S. Ernstoff, Lisa H. Butterfield, Rogerio I. Neves, Joseph J. Drabick, Arivarasan Karunamurthy, Diwakar Davar, Yan Zang, Yan Lin, Huang Lin, Dustin McCurry, Yana G. Najjar
Purpose:Neoadjuvant immunotherapy may improve the clinical outcome of regionally advanced operable melanoma and allows for rapid clinical and pathologic assessment of response. We examined neoadjuvant pembrolizumab and high-dose IFNα-2b (HDI) therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1471b78d10ef705c6b751e83f0d0d685
https://doi.org/10.1158/1078-0432.c.6530735.v1
https://doi.org/10.1158/1078-0432.c.6530735.v1
Autor:
Jennifer Bordeaux, Dustin McCurry, Arivarasan Karunamurthy, Lisa H. Butterfield, Rogerio I. Neves, Anil Pahuja, Matthew P. Holtzman, Beiru Chen, Jehovana Orozco Bender, Ahmad A. Tarhini, Yan Zang, Ju Young Kim, John M. Kirkwood, Yan Lin, Cindy Sander, Joseph J. Skitzki, IlaSri B. Summit, Marc S. Ernstoff, Christian Laing, Joseph J. Drabick, Yana G. Najjar, Huang Lin, Jennifer Tsau, Ghanashyam Sarikonda, Igor Puzanov, Hassane M. Zarour, Zeni Alfonso, Amy Rose, James F. Pingpank, Diwakar Davar
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 27, iss 15
Purpose:Neoadjuvant immunotherapy may improve the clinical outcome of regionally advanced operable melanoma and allows for rapid clinical and pathologic assessment of response. We examined neoadjuvant pembrolizumab and high-dose IFNα-2b (HDI) therap
Autor:
Reinhold Pollner, Ghanashyam Sarikonda, Kevin Nguyen, Anil Pahuja, Creton Kalfoglou, Kerri Burns, Naveen Dakappagari, Irene L. Ch’en, Shabnam Tangri
Publikováno v:
Cytometry Part B: Clinical Cytometry. 100:72-78
Exceptional clinical responses produced by the first chimeric antigen receptor T [CAR-T] cell therapies, and their entry into commercial markets prompted a logarithmic increase in the number of next generation CAR-T clinical trials. As a result, ther
Autor:
Paul C Trampont, Ghanashyam Sarikonda, Virginia Litwin, Laïla-Aïcha Hanafi, Vilma Decman, Anil Pahuja, Yongliang S Sun, Mélissa Mathieu, Michael Nathan Hedrick, Susan Reynolds, Steven Eck, Qiong Xue, Naveen Dakappagari, Jennifer J. Stewart, Shabnam Tangri, Mahwish Natalia, Piotr L Pierog
Publikováno v:
Cytometry. Part B, Clinical cytometryREFERENCES. 100(1)
Chimeric Antigen Receptor (CAR) T cells are recognized as efficacious therapies with demonstrated ability to produce durable responses in blood cancer patients. Regulatory approvals and acceptance of these unique therapies by patients and reimburseme
Autor:
Yvonne J.M Oussoren-Brockhoff, Naveen Dakappagari, Sarah Larson, Xun Li, Maaike E Heidinga, Pedro Marques Ramos, Ling Du, Pavinder Kaur, Jacqueline Cloos, Ghanashyam Sarikonda, Kevin Nguyen, Anil Pahuja, Shabnam Tangri, Angèle Kelder
Publikováno v:
Blood. 136:22-23
Background: Measurable Residual Disease (MRD) assessments are gaining increasing acceptance as a prognostic factor for tailoring treatment in hematological malignancies. Acute Myeloid Leukemia (AML) is a heterogeneous disease with high relapse rates
Autor:
Ahmad A Tarhini, Arjun Khunger, Jane Gao, Ghanashyam Sarikonda, Zeni Alfonso, Naveen Dakappagari, Christian Laing, Jennifer Tsau, Christine Vaupel, Anil Pahuja
Publikováno v:
Translational Oncology, Vol 14, Iss 3, Pp 101014-(2021)
Translational Oncology
Translational Oncology
Highlights • Neoadjuvant ipilimumab and IFNα were evaluated in regionally advanced melanoma. • Immune cellular profiling investigated tumor immune susceptibility and resistance. • Higher levels of peripheral Th1 cell subsets predicted favorabl