Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Anil Kumar Padyana"'
Autor:
Bhamini Vaidialingam, Michael Franti, Priyanka Gupta, Neil A. Farrow, Anil Kumar Padyana, David B. Hayes
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 72:160-164
Members of the TGF-β family of proteins are believed to play critical roles in cellular signaling processes such as those involved in muscle differentiation. The extent to which individual family members have been characterized and linked to biologi
Autor:
Adam Flegg, Tina Morwick, Ho Yin Lo, Todd Bosanac, Weimin Liu, Valentina Berger, Steven Kerr, Stéphane De Lombaert, Paige Erin Mahaney, Ralph Binetti, John Broadwater, Spencer Napier, Alessandra Bartolozzi, Lifen Wu, Hidenori Takahashi, Asitha Abeywardane, Heather Tye, Tazmeen Fadra-Khan, John D. Huber, Adrian Kotey, Ming-Hong Hao, Dines Jonathon Alan, Anil Kumar Padyana, Alan Olague, Michael Garrigou, David S. Thomson, J. Matthew Hutzler, Pui Leng Loke, Renee Zindell, Edward Pack, Zhidong Chen, Rebecca Crux, Thomas Simpson, Rajvee Dave, Doris Riether
Publikováno v:
Journal of Medicinal Chemistry. 58:1669-1690
The synthesis, structure–activity relationship (SAR), and evolution of a novel series of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitors are described. The use of structure-guided drug design techniques provided compounds
Autor:
Xiang Li, Hidenori Takahashi, Steven S. Pullen, Stéphane De Lombaert, Asitha Abeywardane, Ming-Hong Hao, John R. Proudfoot, Anil Kumar Padyana, Brandon Collins, Leslie Martin, Daniel R. Albaugh, Steven John Taylor, Shuang Liang, Bennett Sandy Farmer, Melissa Hill-Drzewi
Publikováno v:
Journal of Medicinal Chemistry. 56:4465-4481
Chymase plays an important and diverse role in the homeostasis of a number of cardiovascular processes. Herein, we describe the identification of potent, selective chymase inhibitors, developed using fragment-based, structure-guided linking and optim
Autor:
Zhaoming Xiong, Stephen J. Boyer, Lida Soleymanzadeh, Stanley Kugler, John Westbrook, Yunlong Zhang, Anil Kumar Padyana, Jennifer Burke, Jeffrey B. Madwed, Derek Cogan, Alan David Swinamer, Chris Sarko, Mohammed A. Kashem, Frank M. DiCapua, Kirrane Thomas M, Amy Gao, Roger J. Snow, Xin Guo, Margaret M. O’Neill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:733-737
A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were identified through high throughput screening. An RSK crystal structure and exploratory SAR
Autor:
Anil Kumar Padyana, Xiang Li, Asitha Abeywardane, Pierre R. Bonneau, René Coulombe, Qiang Zhang, Araz Jakalian, Steven John Taylor, Peter W. White, Steven R. LaPlante, Shuang Liang, Ginette McKercher, Jessi Wildeson-Jones, Mireille Cartier
Publikováno v:
Journal of medicinal chemistry. 57(5)
Future treatments for individuals infected by the hepatitis C virus (HCV) will likely involve combinations of compounds that inhibit multiple viral targets. The helicase of HCV is an attractive target with no known drug candidates in clinical trials.
Autor:
John Xiang Li, Xiang Li, Ingo Muegge, Steven John Taylor, Hani Zaher, Jun Li, Shuang Liang, Bennett T. Farmer, Zhaoming Xiong, Neil A. Farrow, Alexander Heim-Riether, Ljiljana Zuvela-Jelaska, Brandon Collins, Melissa Hill-Drzewi, Daniel E. Goldberg, Qiang Zhang, Asitha Abeywardane, Anil Kumar Padyana, John R. Proudfoot
Publikováno v:
Journal of medicinal chemistry. 54(23)
Matrix metalloproteases (MMPs) play an important role in cartilage homeostasis under both normal and inflamed disease states and, thus, have become attractive targets for the treatment of arthritic diseases. Herein, we describe the identification of
Autor:
Zhaoming Xiong, Anil Kumar Padyana, John R. Proudfoot, Neil A. Farrow, Ingo Muegge, Daniel E. Goldberg, Brandon Collins, Bennett T. Farmer, Ljiljana Zuvela-Jelaska, Alexander Heim-Riether, Shuang Liang, Asitha Abeywardane, Steven John Taylor, Melissa Hill-Drzewi, Qiang Zhang, Jun Li, John Li, Xiang Li, Hani Zaher
Publikováno v:
Journal of Medicinal Chemistry. 58:6318-6318