Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Anil Kumar Challa"'
Autor:
Raghavender Medishetti, Keerthana Balamurugan, Krishnaveni Yadavalli, Rita Rani, Aarti Sevilimedu, Anil Kumar Challa, Kishore Parsa, Kiranam Chatti
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101779- (2022)
Summary: The application of CRISPR has greatly facilitated genotype-phenotype studies of human disease models. In this protocol, we describe CRISPR-Cas9-induced gene knockout in zebrafish, utilizing purified Cas9 protein and in vitro-transcribed sgRN
Externí odkaz:
https://doaj.org/article/324fb06899d64991bbddeedcf320850e
Publikováno v:
Biochemistry and Biophysics Reports, Vol 28, Iss , Pp 101138- (2021)
Objective: Hydroxyacylglutathione hydrolase (aka as GLO-2) is a component of the glyoxalase pathway involved in the detoxification of the reactive oxoaldehydes, glyoxal and methylglyoxal. These reactive metabolites have been linked to a variety of pa
Externí odkaz:
https://doaj.org/article/cbca25f732c047218b18091d90072a31
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Undergraduate microbiology curriculum should be amenable to periodic changes to incorporate new developments and ideas. The curriculum should be used not merely as a way to disseminate facts but also as a way to allow students to experience the proce
Externí odkaz:
https://doaj.org/article/e36aa03784ce479abddee161fa7329ce
Autor:
Gobinath Shanmugam, Anil Kumar Challa, Silvio H. Litovsky, Asokan Devarajan, Ding Wang, Dean P. Jones, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran
Publikováno v:
Redox Biology, Vol 27, Iss , Pp - (2019)
Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/Nrf2) is an inducible transcription factor that is essential for maintenance of redox signaling in response to stress. This suggests that if Nrf2 expression response could be enhanced for a defined
Externí odkaz:
https://doaj.org/article/d793471ae9e74e498465e7ebe4d51c7a
Autor:
Jay M. Bhatt, Anil Kumar Challa
Publikováno v:
Journal of Microbiology & Biology Education, Vol 19, Iss 1 (2018)
Genetic analysis in model systems can provide a rich context for conceptual understanding of gene structure, regulation, and function. With an intent to create a rich learning experience in molecular genetics, we developed a semester-long course-base
Externí odkaz:
https://doaj.org/article/689d11fd0b4d45fe8562afed355c731a
Autor:
Arun Jyothidasan, Saravanakumar Murugesan, Justin Quiles, Anil Kumar Challa, Senthil Kumar Cinghu, Vivek Nanda, Rajasekaran N Namakkal-Soorappan
Publikováno v:
Circulation Research. 131
Background: NFE2L2, nuclear factor, erythroid 2 like 2 (Nrf2), is a transcription factor that protects cells through maintaining a homeostatic redox state during stress. Constitutive expression of Nrf2 (CaNrf2-TG) was previously shown to be pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7f09a1b52388eb2291dbca1dc1f2e3
https://doi.org/10.1161/res.131.suppl_1.p3091
https://doi.org/10.1161/res.131.suppl_1.p3091
Autor:
Arun, Jyothidasan, Sini, Sunny, Saravanakumar, Murugesan, Justin M, Quiles, Anil Kumar, Challa, Brian, Dalley, Senthil Kumar, Cinghu, Vivek, Nanda, Namakkal-Soorappan, Rajasekaran
Publikováno v:
Genes; Volume 13; Issue 9; Pages: 1514
Nuclear factor, erythroid 2 like 2 (Nfe2l2 or Nrf2), is a transcription factor that protects cells by maintaining a homeostatic redox state during stress. The constitutive expression of Nrf2 (CaNrf2-TG) was previously shown to be pathological to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03cfbf0f0ee9489d2bdab42f2e68714
https://doi.org/10.3390/genes13091514
https://doi.org/10.3390/genes13091514
Autor:
Dean P. Jones, Jolyn Fernandes, Silvio H. Litovsky, Gobinath Shanmugam, Rajasekaran Namakkal-Soorappan, Anil Kumar Challa
Publikováno v:
Circulation Research. 123
Background: Nuclear factor (erythroid-derived 2)-like 2 (NEFL2/Nrf2) is an inducible transcription factor that is crucial to fight against stress caused by various means (i.e. oxidative or xenobiotic stresses). While the Nrf2 has a negligible role on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cbf9f53bd799833e1586a5802c5cf29
https://doi.org/10.1161/res.123.suppl_1.425
https://doi.org/10.1161/res.123.suppl_1.425
Autor:
Rajasekaran Namakkal-Soorappan, Mark E Pepin, Adam R Wende, David K. Crossman, Senthilkumar Cinghu, Justin M Quiles, Anil Kumar Challa
Publikováno v:
Circulation Research. 123
Background: Transient activation of nuclear factor, erythroid 2 like 2 (Nfe2l2/Nrf2), a master regulator of antioxidant transcription, protects from oxidative insult. However, sustained Nrf2 signaling causes proteotoxic reductive stress (RS). Using N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a14ccdc058581570c03f2c9b2f326782
https://doi.org/10.1161/res.123.suppl_1.234
https://doi.org/10.1161/res.123.suppl_1.234
Autor:
Divya Saro Varghese, Thilina T. Alawathugoda, Muhammad Abid Sheikh, Anil Kumar Challagandla, Bright Starling Emerald, Suraiya A. Ansari
Publikováno v:
Cell Death and Disease, Vol 13, Iss 8, Pp 1-13 (2022)
Abstract Obesity is a multigene disorder. However, in addition to genetic factors, environmental determinants also participate in developing obesity and related pathologies. Thus, obesity could be best described as a combination of genetic and enviro
Externí odkaz:
https://doaj.org/article/b89197db15e14adca77463ce3e684b57