Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anil Kumar, Marapaka"'
Autor:
Simone Giovannuzzi, Anil Kumar Marapaka, Nader S. Abutaleb, Fabrizio Carta, Hsin-Wen Liang, Alessio Nocentini, Luigi Pisano, Mohamed N. Seleem, Daniel P. Flaherty, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Carbonic anhydrases (CAs) from the pathogenic bacteria Nesseria gonorrhoeae and vancomycin-resistant enterococci (VRE) have recently been validated as antibacterial drug targets. Here we explored the inhibition of the α-CA from N. gonorrhoeae (α-Ng
Externí odkaz:
https://doaj.org/article/c4d2014469974e81944e86da38a9887d
Autor:
Puran Singh Sijwali, Yongzheng Ding, Chunhua Ma, Vijaykumar Pillalamarri, Priyanka Sankoju, Yingjie Zhang, Bharati Reddi, Anil Kumar Marapaka, Guozhen Zhang, Anthony Addlagatta, Renu Sudhakar
Publikováno v:
Chinese Chemical Letters. 33:2550-2554
Plasmodium parasites causing malaria have developed resistance to most of the antimalarials in use, including the artemisinin-based combinations, which are the last line of defense against malaria. This necessitates the discovery of new targets and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f701acc612348fbdf869eb03d63407
https://doi.org/10.1016/j.cclet.2021.09.102
https://doi.org/10.1016/j.cclet.2021.09.102
Autor:
Amanda L. Graboski, Xufeng Cao, Yehia Elgammal, Devon P. Amos, Molly S. Youse, Alessio Nocentini, Nader S. Abutaleb, Anil Kumar Marapaka, Weiwei An, Mohamed N. Seleem, Claudiu T. Supuran, Ahmed E. M. Elhassanny, Katrina J. Holly, Chad S. Hewitt, Daniel P. Flaherty, Jatinder Kaur, Aaron D Krabill, Ahmed Elkashif
Publikováno v:
ACS Infectious Diseases. 7:1969-1984
Neisseria gonorrhoeae is an urgent threat to public health in the United States and around the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are quickly becoming obsolete due to increased rates of resistance. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::506c99f38b00123de518cee832d6beb7
https://doi.org/10.1021/acsinfecdis.1c00055
https://doi.org/10.1021/acsinfecdis.1c00055
Autor:
Naga Veera Yerra, Anthony Addlagatta, Sandeep Chowdary Bala, Neshatul Haque, Anil Kumar Marapaka, Ravikumar Reddi, Roopa Jones Ganji
Publikováno v:
International Journal of Biological Macromolecules. 165:1373-1381
Puromycin sensitive aminopeptidase (PSA or NPEPPS) is a M1 class aminopeptidase is selectively inhibited by the natural product puromycin, an aminonucleoside antibiotic produced by the bacterium Streptomyces alboniger. The molecular basis for this se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef27de839b722bee0d687375f32736ec
https://doi.org/10.1016/j.ijbiomac.2020.10.035
https://doi.org/10.1016/j.ijbiomac.2020.10.035
Autor:
Emmanuel Salomon, Marjorie Schmitt, Anil Kumar Marapaka, Athanasios Stamogiannos, Germain Revelant, Céline Schmitt, Sarah Alavi, Isabelle Florent, Anthony Addlagatta, Efstratios Stratikos, Céline Tarnus, Sébastien Albrecht
Publikováno v:
Molecules, Vol 23, Iss 10, p 2607 (2018)
The synthesis of racemic substituted 7-amino-5,7,8,9-tetrahydrobenzocyclohepten-6-one hydrochlorides was optimized to enhance reproducibility and increase the overall yield. In order to investigate their specificity, series of enzyme inhibition assay
Externí odkaz:
https://doaj.org/article/a41b8b21636742c292437496ce0361ef
Autor:
Chad S, Hewitt, Nader S, Abutaleb, Ahmed E M, Elhassanny, Alessio, Nocentini, Xufeng, Cao, Devon P, Amos, Molly S, Youse, Katrina J, Holly, Anil Kumar, Marapaka, Weiwei, An, Jatinder, Kaur, Aaron D, Krabill, Ahmed, Elkashif, Yehia, Elgammal, Amanda L, Graboski, Claudiu T, Supuran, Mohamed N, Seleem, Daniel P, Flaherty
Publikováno v:
ACS Infect Dis
Neisseria gonorrhoeae is an urgent threat to public health in the United States and around the world. Many of the current classes of antibiotics to treat N. gonorrhoeae infection are quickly becoming obsolete due to increased rates of resistance. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::276a76d58342871c1deb2f7fde0604e6
https://pubmed.ncbi.nlm.nih.gov/33765392
https://pubmed.ncbi.nlm.nih.gov/33765392
Autor:
Swetha Garimella, Ramchander Merugu, Anil Kumar Marapaka, Kanchana Latha Chitturi, Karunakar Rao Kudle
Publikováno v:
Journal of Bionanoscience. 12:284-289
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c700e46a58dff30cc615b29abd780cf
https://doi.org/10.1166/jbns.2018.1520
https://doi.org/10.1166/jbns.2018.1520
Autor:
Neshatul Haque, Anil Kumar Marapaka, Anthony Addlagatta, Sandeep Chowdary Bala, Ravikumar Reddi, Rajnandani Kashyap, Vijaykumar Pillalamarri
Publikováno v:
International journal of biological macromolecules. 129
Methionine aminopeptidases (MetAPs) are a class of enzymes evolved to cleave initiator methionine in 60-70% of the total cellular proteins in all living cells. Based on their sequence differences, they are classified into Type 1 and Type 2. Type 1 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf73877f47a214aa5d799cc635975120
https://pubmed.ncbi.nlm.nih.gov/30763644
https://pubmed.ncbi.nlm.nih.gov/30763644
Autor:
Neshatul Haque, Anil Kumar Marapaka, Sandeep Chowdary Bala, Vijaykumar Pillalamarri, Anthony Addlagatta, Tarun Arya
Publikováno v:
The Biochemical journal. 476(6)
Natural product ovalicin and its synthetic derivative TNP-470 have been extensively studied for their antiangiogenic property, and the later reached phase 3 clinical trials. They covalently modify the conserved histidine in Type 2 methionine aminopep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7994e90e693bd2dd686f63d5ae4d350a
https://pubmed.ncbi.nlm.nih.gov/30837307
https://pubmed.ncbi.nlm.nih.gov/30837307
Autor:
Aruna Jangam, Neshatul Haque, Anil Kumar Marapaka, Vijaykumar Pillalamarri, Anthony Addlagatta, Sandeep Chowdary Bala, Rajesh Gumpena
Publikováno v:
International journal of biological macromolecules. 120
Aminopeptidases catalyze the hydrolysis of amino acids from the N-terminus of protein or peptide substrates. M1 family aminopeptidases are important for the pathogenicity of bacteria and play critical role in many physiological processes such as prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef321c4a566b6ac7d33ffd885f551812
https://pubmed.ncbi.nlm.nih.gov/30172821
https://pubmed.ncbi.nlm.nih.gov/30172821