Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Anil K. Tyagi"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract ideR, an essential gene of Mycobacterium tuberculosis, is an attractive drug target as its conditional knockout displayed attenuated growth phenotype in vitro and in vivo. To the best of our knowledge, no inhibitors of IdeR are identified. W
Externí odkaz:
https://doaj.org/article/d2e3220ed8cb46e1bec8bc9826d399ec
Publikováno v:
Biology Open, Vol 7, Iss 1 (2018)
Previously we had developed a triple gene mutant of Mycobacterium tuberculosis (MtbΔmms) harboring disruption in three genes, namely mptpA, mptpB and sapM. Though vaccination with MtbΔmms strain induced protection in the lungs of guinea pigs, the m
Externí odkaz:
https://doaj.org/article/e91df8487c4b4deea5ce22b9ca866498
Autor:
Syed Asad Rahman, Yadvir Singh, Sakshi Kohli, Javeed Ahmad, Nasreen Z. Ehtesham, Anil K. Tyagi, Seyed E. Hasnain
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
Externí odkaz:
https://doaj.org/article/f074c78527f64bdcb02814c9ed857482
Autor:
Syed Asad Rahman, Yadvir Singh, Sakshi Kohli, Javeed Ahmad, Nasreen Z. Ehtesham, Anil K. Tyagi, Seyed E. Hasnain
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT Mycobacterial evolution involves various processes, such as genome reduction, gene cooption, and critical gene acquisition. Our comparative genome size analysis of 44 mycobacterial genomes revealed that the nonpathogenic (NP) genomes were bi
Externí odkaz:
https://doaj.org/article/da596650dd8d4381aa13d51882a21069
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179513 (2017)
Owing to the devastation caused by tuberculosis along with the unsatisfactory performance of the Bacillus Calmette-Guérin (BCG) vaccine, a more efficient vaccine than BCG is required for the global control of tuberculosis. A number of studies have d
Externí odkaz:
https://doaj.org/article/25a3cef352a64dc6be0109af0b5f93f2
Autor:
Amit Singh, Radhika Gupta, R. A. Vishwakarma, P. R. Narayanan, C. N. Paramasivan, V. D. Ramanathan, Anil K. Tyagi
Publikováno v:
Journal of Bacteriology. 204
Publikováno v:
Journal of Biological Chemistry. 294:10055-10075
The ability of Mycobacterium tuberculosis to respond and adapt to various stresses such as oxygen/nitrogen radicals and low pH inside macrophages is critical for the persistence of this human pathogen inside its host. We have previously shown that an
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e92035 (2014)
In host cells, Mycobacterium tuberculosis encounters an array of reactive molecules capable of damaging its genome. Non-bulky DNA lesions are the most common damages produced on the exposure of the pathogen to reactive species and base excision repai
Externí odkaz:
https://doaj.org/article/5145396e0281485eaf5b169d1aaf19ec
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70514 (2013)
Tuberculosis (TB) is responsible for nearly 1.4 million deaths globally every year and continues to remain a serious threat to human health. The problem is further complicated by the growing incidence of multidrug-resistant TB (MDR-TB) and extensivel
Externí odkaz:
https://doaj.org/article/8c46e24490f74e3dbdc765bc002a0bb0
Autor:
Priyanka Chauhan, P Vineel Reddy, Ramandeep Singh, Neetika Jaisinghani, Sheetal Gandotra, Anil K Tyagi
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77930 (2013)
BACKGROUND:The failure of Mycobacterium bovis Bacille Calmette-Guérin to impart satisfactory protection against adult pulmonary tuberculosis has necessitated the development of more effective TB vaccines. The assumption that the vaccine strain shoul
Externí odkaz:
https://doaj.org/article/716eb8de14a547d6a211e48255d39f78