Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Anil K. Padyana"'
Autor:
SeHee Park, Erin E. Doherty, Yixuan Xie, Anil K. Padyana, Fang Fang, Yue Zhang, Agya Karki, Carlito B. Lebrilla, Justin B. Siegel, Peter A. Beal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human ADAR proteins are responsible for RNA editing, conversion of adenosine to inosine in double-stranded RNA. Here the authors report a previously unknown zinc ion-binding site in the catalytic domain of human ADAR1 using high throughput mutagenesi
Externí odkaz:
https://doaj.org/article/2cab59460beb46e3b35941eb8878c251
Autor:
Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol bios
Externí odkaz:
https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
Autor:
Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and is a target for hypercholesteremia and cancer drug development. Here the authors present the crystal structures of the human SQLE catalytic domain alone and bound with small mo
Externí odkaz:
https://doaj.org/article/13114a6254b94cd5a8f05eeabf842c50
Autor:
Brandon M. Gassaway, Rebecca L. Cardone, Anil K. Padyana, Max C. Petersen, Evan T. Judd, Sebastian Hayes, Shuilong Tong, Karl W. Barber, Maria Apostolidi, Abudukadier Abulizi, Joshua B. Sheetz, Kshitiz, Hans R. Aerni, Stefan Gross, Charles Kung, Varman T. Samuel, Gerald I. Shulman, Richard G. Kibbey, Jesse Rinehart
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3394-3404.e9 (2019)
Summary: Pyruvate kinase is an important enzyme in glycolysis and a key metabolic control point. We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-f
Externí odkaz:
https://doaj.org/article/843a5a89bddc469f9d601bd5b6452f15
Autor:
Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald
GO analysis of proteins with at least a 1.5-fold increase in expression in the presence of AG-636 compared to DMSO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b4ca858542c027e4592c9d144d2e2b
https://doi.org/10.1158/1535-7163.22520980.v1
https://doi.org/10.1158/1535-7163.22520980.v1
Autor:
Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald
Supplementary methods, references and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0375725bf558a85632625bf90c45d1f
https://doi.org/10.1158/1535-7163.22520971
https://doi.org/10.1158/1535-7163.22520971
Autor:
Danielle B. Ulanet, Kevin M. Marks, Josh Murtie, Scott A. Biller, Jonathan Hurov, Georg Lenz, Lenny Dang, Nelamangala Nagaraja, Zhihua Sui, Sreevalsam Gopinath, Thomas Antony, Sunil K. Panigrahi, K. Satish Reddy, Hosahalli Subramanya, Siva Sanjeeva Rao, Kavitha Nellore, Mark Fletcher, Sebastian Hayes, Alan Mann, Tabea Erdmann, Zi-Peng Fan, Charles Locuson, Sebastien Ronseaux, Lei Jin, Anil K. Padyana, Erin Artin, Mya Steadman, Sung Choe, Rohini Narayanaswamy, Kevin Truskowski, John Coco, Victor Chubukov, Gabrielle McDonald
Agents targeting metabolic pathways form the backbone of standard oncology treatments, though a better understanding of differential metabolic dependencies could instruct more rationale-based therapeutic approaches. We performed a chemical biology sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c2082a01fe43de83bde9d3812f1570
https://doi.org/10.1158/1535-7163.c.6542857
https://doi.org/10.1158/1535-7163.c.6542857
Autor:
Joshua Murtie, Anil K. Padyana, Lei Jin, Marc L. Hyer, Zhixiao Liu, Scott A. Biller, Jeremy Travins, Amelia Barnett, Katya Marjon, Brandon Nicolay, Wentao Wei, Raj Nagaraja, Cheng Fang, Yi Gao, Yabo Sun, Ye Zhixiong, Fan Jiang, Peter Kalev, Stefan Gross, Zenon D. Konteatis, Byron DeLaBarre, Zhihua Sui, Kevin Marks, Lenny Dang, Jie Yu, Everton Mandley, Yue Chen
Publikováno v:
Journal of Medicinal Chemistry. 64:4430-4449
The metabolic enzyme methionine adenosyltransferase 2A (MAT2A) was recently implicated as a synthetic lethal target in cancers with deletion of the methylthioadenosine phosphorylase (MTAP) gene, which is adjacent to the CDKN2A tumor suppressor and co
Autor:
Mingzong Li, Zenon Konteatis, Nelamangala Nagaraja, Yue Chen, Shubao Zhou, Guangning Ma, Stefan Gross, Katya Marjon, Marc L. Hyer, Everton Mandley, Max Lein, Anil K. Padyana, Lei Jin, Shuilong Tong, Rachel Peters, Joshua Murtie, Jeremy Travins, Matthew Medeiros, Peng Liu, Victoria Frank, Evan T. Judd, Scott A. Biller, Kevin M. Marks, Zhihua Sui, Samuel K. Reznik
Publikováno v:
Journal of medicinal chemistry. 65(6)
Inhibition of the
Autor:
Brandon Nicolay, Ingo K. Mellinghoff, Paolo Codega, Hua Yang, Zenon D. Konteatis, Janeta Popovici-Muller, Katharine E. Yen, Rohini Narayaraswamy, Raj Nagaraja, Zhihua Sui, Shinsan M. Su, Erin Artin, Kimberly Straley, Zhenwei Cai, Feng Wang, Shuilong Tong, Lei Jin, Yue Chen, Cui Dawei, Carl Campos, Zhiyong Luo, Cheng Fang, Xiaobing Lv, Lenny Dang, Ding Zhou, Anil K. Padyana, Huachun Tang, Scott A. Biller
Publikováno v:
ACS Medicinal Chemistry Letters
Inhibitors of mutant isocitrate dehydrogenase (mIDH) 1 and 2 cancer-associated enzymes prevent the accumulation of the oncometabolite d-2-hydroxyglutarate (2-HG) and are under clinical investigation for the treatment of several cancers harboring an I