Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Anil K. Challa"'
Autor:
Natalie R. Forte, Virginia N. Veasey, Bethany J. Christie, Amira Carter, Marli A. Hanks, Alan Holderfield, Taylor Houston, Anil K. Challa, Ashley N. Turner
Publikováno v:
Journal of Microbiology & Biology Education, Vol 24, Iss 3 (2023)
ABSTRACTGenetic analysis in model systems using bioinformatic approaches provides a rich context for a concrete and conceptual understanding of gene structure and function. With the intent to engage students in research and explore disease biology ut
Externí odkaz:
https://doaj.org/article/5e10066d625c43a8bb34a950defbac26
Autor:
Haifa Alsharif, Mary N. Latimer, Katherine C. Perez, Justin Alexander, Md Mostafizur Rahman, Anil K. Challa, Jeong-A. Kim, Sasanka Ramanadham, Martin Young, Sushant Bhatnagar
Publikováno v:
Metabolites, Vol 13, Iss 6, p 711 (2023)
Effective energy expenditure is critical for maintaining body weight (BW). However, underlying mechanisms contributing to increased BW remain unknown. We characterized the role of brain angiogenesis inhibitor-3 (BAI3/ADGRB3), an adhesion G-protein co
Externí odkaz:
https://doaj.org/article/6db45d1f199a4eb3b7390d521cd46ac2
Autor:
Justin M. Quiles, Mark E. Pepin, Sini Sunny, Sandeep B. Shelar, Anil K. Challa, Brian Dalley, John R. Hoidal, Steven M. Pogwizd, Adam R. Wende, Namakkal S. Rajasekaran
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Although recent advances in the treatment of acute coronary heart disease have reduced mortality rates, few therapeutic strategies exist to mitigate the progressive loss of cardiac function that manifests as heart failure. Nuclear factor, er
Externí odkaz:
https://doaj.org/article/0bacb871034845faa009f27435e581fe
Autor:
Anil K. Challa, Denise Stanford, Antonio Allen, Lawrence Rasmussen, Ferdinand K. Amanor, S. Vamsee Raju
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101419- (2021)
Successful use of the CRISPR-Cas9 system for gene manipulation relies on identifying effective and efficient guide RNA sequences (gRNAs). When the goal is to create transgenic animal/rodent models by knocking-in desired sequences using homology-direc
Externí odkaz:
https://doaj.org/article/97db05d24003470688d7865de3b81fb2
Autor:
Garrett Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M. Tennessen, Juan Liu, Jason W. Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L. Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K. Challa, Sunil Sudarshan
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 11 (2020)
L-2-hydroxyglutarate (L-2HG) is an oncometabolite found elevated in renal tumors. However, this molecule might have physiological roles that extend beyond its association with cancer, as L-2HG levels are elevated in response to hypoxia and during Dro
Externí odkaz:
https://doaj.org/article/6dd4f46ccd38444ea52f902f75ef43e0
Autor:
Laura J. Lambert, Anil K. Challa, Aidi Niu, Lihua Zhou, Janusz Tucholski, Maria S. Johnson, Tim R. Nagy, Alan W. Eberhardt, Patrick N. Estep, Robert A. Kesterson, Jayleen M. Grams
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 10, Pp 1169-1179 (2016)
Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of osteocalcin deficiency has implicated osteocalcin as a mediator of changes t
Externí odkaz:
https://doaj.org/article/4416ba08da51475b9e8b9c3f546ec6a0
Autor:
Gobinath Shanmugam, Anil K. Challa, Asokan Devarajan, Baskaran Athmanathan, Silvio H. Litovsky, Prasanna Krishnamurthy, Christopher J. Davidson, Namakkal Soorappan Rajasekaran
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Although exercise derived activation of Nrf2 signaling augments myocardial antioxidant signaling, the molecular mechanisms underlying the benefits of moderate exercise training (MET) in the heart remain elusive. Here we hypothesized that exercise tra
Externí odkaz:
https://doaj.org/article/b7425631e0854972ae1c0e78b74a584d
Autor:
Michael J. Wolyniak, Shane Austin, Lucian F. Bloodworth, Dawn Carter, Scott H. Harrison, Tiffany Hoage, Lisa Hollis-Brown, Felicia Jefferson, Alison Krufka, Farida Safadi-Chamberlin, Maria S. Santisteban, Paula Soneral, Beth VanWinkle, Anil K. Challa
Publikováno v:
Journal of Microbiology & Biology Education, Vol 20, Iss 1 (2019)
As CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 technology becomes more mainstream in life science research, it becomes critical for undergraduate instructors to devise engaging ways to bring the technology into their class
Externí odkaz:
https://doaj.org/article/f15d4f3bf01248cbbba7bf9b99092be9
Autor:
Myron S. Ignatius, Kunal Baxi, Amanda Lipsitt, Anil K. Challa, Nicole R. Hensch, Jiangfei Chen, Rodrigo Moreno-Campos, Eleanor Y. Chen
Publikováno v:
Zebrafish. 18:293-296
Angiosarcoma is a clinically aggressive tumor with a high rate of mortality. It can arise in vascular or lymphatic tissues, involve any part of the body, and aggressively spread locally or metastasize. Angiosarcomas spontaneously develop in the tp53
Autor:
Sini Sunny, Namakkal S. Rajasekaran, Justin M. Quiles, Adam R. Wende, Sandeep B. Shelar, Steven M. Pogwizd, John R. Hoidal, Brian Dalley, Mark E Pepin, Anil K. Challa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Although recent advances in the treatment of acute coronary heart disease have reduced mortality rates, few therapeutic strategies exist to mitigate the progressive loss of cardiac function that manifests as heart failure. Nuclear factor, erythroid 2