Zobrazeno 1 - 10
of 1 506
pro vyhledávání: '"Anil K Sood"'
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 34-42 (2016)
MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression. miRNAs have been established as master regulators of cellular proc
Externí odkaz:
https://doaj.org/article/e4889dd80e78466f91c77476eff234ad
Autor:
Benjamin B Shields, Chad V Pecot, Hua Gao, Elizabeth McMillan, Malia Potts, Christa Nagel, Scott Purinton, Ying Wang, Cristina Ivan, Hyun Seok Kim, Robert J Borkowski, Shaheen Khan, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Jayanthi Lea, Adi Gazdar, Keith A Baggerly, Anil K Sood, Michael A White
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 12, Pp 1-17 (2015)
Abstract Large‐scale molecular annotation of epithelial ovarian cancer (EOC) indicates remarkable heterogeneity in the etiology of that disease. This diversity presents a significant obstacle against intervention target discovery. However, inactiva
Externí odkaz:
https://doaj.org/article/72ff6360f5ac463998c7bb990ecfe729
Autor:
Myrthala Moreno-Smith, Sun Joo Lee, Chunhua Lu, Archana S Nagaraja, Guangan He, Rajesha Rupaimoole, Hee Dong Han, Nicholas B Jennings, Ju-Won Roh, Masato Nishimura, Yu Kang, Julie K Allen, Guillermo N Armaiz, Koji Matsuo, Mian M K Shahzad, Justin Bottsford-Miller, Robert R Langley, Steve W Cole, Susan K Lutgendorf, Zahid H Siddik, Anil K Sood
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 5, Pp 502-510 (2013)
Chronic sympathetic nervous system activation results in increased angiogenesis and tumor growth in orthotopic mouse models of ovarian carcinoma. However, the mechanistic effects of such activation on the tumor vasculature are not well understood. Do
Externí odkaz:
https://doaj.org/article/c038a14994e24300a16ad6c36cef2b13
Autor:
Shu Zhang, Zhen Lu, Weiqun Mao, Ahmed A Ahmed, Hailing Yang, Jinhua Zhou, Nicholas Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Roberto Miranda, Wei Qiao, Veera Baladandayuthapani, Zongfang Li, Anil K Sood, Jinsong Liu, Xiao-Feng Le, Robert C Bast
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131833 (2015)
Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ov
Externí odkaz:
https://doaj.org/article/cbbd8a5e117f459093a006bc7bf4fb97
Autor:
Murali K Ravoori, Masato Nishimura, Sheela P Singh, Chunhua Lu, Lin Han, Brian P Hobbs, Sunila Pradeep, Hyun J Choi, James A Bankson, Anil K Sood, Vikas Kundra
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131095 (2015)
To assess whether T1 relaxation time of tumors may be used to assess response to bevacizumab anti-angiogenic therapy.12 female nude mice bearing subcutaneous SKOV3ip1-LC ovarian tumors were administered bevacizumab (6.25ug/g, n=6) or PBS (control, n=
Externí odkaz:
https://doaj.org/article/e24d580dbb8646d0b56465a69caef1f9
Autor:
Sanjib Bhattacharyya, Sounik Saha, Karuna Giri, Ian R Lanza, K Sreekumar Nair, Nicholas B Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Eati Basal, Amy L Weaver, Daniel W Visscher, William Cliby, Anil K Sood, Resham Bhattacharya, Priyabrata Mukherjee
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79167 (2013)
Epithelial ovarian cancer is the leading cause of gynecologic cancer deaths. Most patients respond initially to platinum-based chemotherapy after surgical debulking, however relapse is very common and ultimately platinum resistance emerges. Understan
Externí odkaz:
https://doaj.org/article/e401b4b3747d45a6a4a6dee9c9bd8298
Autor:
Ibrahim Tekedereli, S Neslihan Alpay, Ugur Akar, Erkan Yuca, Cristian Ayugo-Rodriguez, He-Dong Han, Anil K Sood, Gabriel Lopez-Berestein, Bulent Ozpolat
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Bcl-2 is overexpressed in about a half of human cancers and 50–70% of breast cancer patients, thereby conferring resistance to conventional therapies and making it an excellent therapeutic target. Small interfering RNA (siRNA) offers novel and powe
Externí odkaz:
https://doaj.org/article/491a4bca1ba8498ca5d9ccce4c1c55fb
Autor:
Lorenzo Cohen, Steven W Cole, Anil K Sood, Sarah Prinsloo, Clemens Kirschbaum, Jesusa M G Arevalo, Nicholas B Jennings, Shellie Scott, Luis Vence, Qi Wei, Diane Kentor, Laszlo Radvanyi, Nizar Tannir, Eric Jonasch, Pheroze Tamboli, Louis Pisters
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42324 (2012)
Evidence has supported the association between psychological factors and cancer biology; however, findings are equivocal on the role of psychosocial factors in cancer progression. This study generates a hypothesis of mechanistic variables by examinin
Externí odkaz:
https://doaj.org/article/f2cdf7bc64864c7a9d991ebbfd6e647d
Autor:
Ibrahim Tekedereli, S Neslihan Alpay, Clint D J Tavares, Zehra E Cobanoglu, Tamer S Kaoud, Ibrahim Sahin, Anil K Sood, Gabriel Lopez-Berestein, Kevin N Dalby, Bulent Ozpolat
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41171 (2012)
Eukaryotic elongation factor 2 kinase (eEF-2K), through its phosphorylation of elongation factor 2 (eEF2), provides a mechanism by which cells can control the rate of the elongation phase of protein synthesis. The activity of eEF-2K is increased in r
Externí odkaz:
https://doaj.org/article/7b1050ea3c5247ddb961e153def8c789
Autor:
Yanling Wang, Xiaowen Hu, Joel Greshock, Liang Shen, Xiaojun Yang, Zhongjun Shao, Shun Liang, Janos L Tanyi, Anil K Sood, Lin Zhang
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44399 (2012)
In human cancer, expression of the let-7 family is significantly reduced, and this is associated with shorter survival times in patients. However, the mechanisms leading to let-7 downregulation in cancer are still largely unclear. Since an alteration
Externí odkaz:
https://doaj.org/article/24a79feb93d84303acefd4a60e261bf1