Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Anil K, Bhunia"'
Publikováno v:
International journal of impotence research
cGMP-independent nitric oxide (NO) signaling occurs via S-nitrosylation. We evaluated whether aberrant S-nitrosylation operates in the penis under conditions of cavernous nerve injury and targets proteins involved in regulating erectile function. Adu
Autor:
Alan T. Remaley, Janna V. Serbo, Robert N. Cole, Deepesh Pandey, Jennifer E. Van Eyk, Anil K. Bhunia, Lewis H. Romer, Young J Oh, Jae Hyung Kim, Fumin Chang, Dan E. Berkowitz, Yehudit Bergman, Tatiana Boronina
Publikováno v:
Circulation Research. 115:450-459
Rationale : Increased arginase activity contributes to endothelial dysfunction by competition for l -arginine substrate and reciprocal regulation of nitric oxide synthase (NOS). The rapid increase in arginase activity in human aortic endothelial cell
Autor:
M. Zulfiquer Hossain, Scott E. Kern, Surojit Sur, Carlo Rago, Soma Ghosh, Yunzhao R. Ren, Bogdan C. Paun, Sashidhar R. Yerram, Nilofer A. Azad, Anil K. Bhunia, Christine A. Iacobuzio-Donahue
Publikováno v:
The American Journal of Pathology. 184(1):260-270
Large-magnitude numerical distinctions (>10-fold) among drug responses of genetically contrasting cancers were crucial for guiding the development of some targeted therapies. Similar strategies brought epidemiological clues and prevention goals for g
Autor:
M. Zulfiquer Hossain, Scott E. Kern, Soma Ghosh, Sam J. Gilbert, Anil K. Bhunia, Kalpesh Patel
Publikováno v:
Food and Chemical Toxicology. 55:557-567
Population differences in age-related diseases and cancer could stem from differences in diet. To characterize DNA strand-breaking activities in selected foods/beverages, flavorings, and some of their constituent chemicals, we used p53R cells, a cell
Publikováno v:
The Journal of Sexual Medicine. 14:e35-e36
Autor:
Dan E. Berkowitz, Simran K. Jandu, Alanah Webb, Jessilyn Dunn, Anil K. Bhunia, Lakshmi Santhanam, Alina Pak, Sarah R. Gutbrod
Publikováno v:
Molecular and Cellular Biochemistry. 355:83-89
Arginase constrains endothelial nitric oxide synthase activity by competing for the common substrate, L -Arginine. We have recently shown that inducible nitric oxide synthase (NOS2) S-nitrosates and activates arginase 1 (Arg1) leading to age-associat
Autor:
Hagit Ashush, Steven D. Shapiro, Anil K. Bhunia, Aneta Gandjeva, Shyam Biswal, Gregory P. Cosgrove, Majd Mouded, Amy Richter, Thomas E. Sussan, Elena Feinstein, Rajesh K. Thimmulappa, Natalie Notkin, Mario J. Perez, Li Zhang, Emile N. Brown, Rubin M. Tuder, Toshinori Yoshida, Lijie Zhen, Anna Gelfand, Irina Petrache, Tirumalai Rangasamy, Tianzhi Mao, Igor Mett, Ugonma Chukwueke, Joel Bowman
Publikováno v:
Nature Medicine. 16:767-773
Rtp801 (also known as Redd1, and encoded by Ddit4), a stress-related protein triggered by adverse environmental conditions, inhibits mammalian target of rapamycin (mTOR) by stabilizing the TSC1-TSC2 inhibitory complex and enhances oxidative stress-de
Autor:
Alessandra Boletta, Feng Qian, Gianfranco Distefano, Gregory G. Germino, Manila Boca, Anil K. Bhunia
Publikováno v:
Journal of the American Society of Nephrology. 17:637-647
Polycystin-1 (PC-1), the PKD1 gene product, is a large receptor whose expression in renal epithelial cells results in resistance to apoptosis and tubulogenesis, a model consistent with the phenotype observed in patients. This study links PC-1 express
Autor:
Alessandra Boletta, Gregory G. Germino, Lijuan Liu, Pei Ning Xu, Anil K. Bhunia, F. Joseph Germino, Feng Qian, Klaus Piontek
Publikováno v:
Cell. 109(2):157-168
Autosomal dominant polycystic kidney disease is characterized by cyst formation in the kidney and other organs and results from mutations of PKD1 or PKD2. Previous studies suggest that their gene products have an important role in growth regulation.
Autor:
Urmil Dhru, Kalpesh Patel, Bogdan C. Paun, Soma Ghosh, Anil K. Bhunia, Scott E. Kern, Sam J. Gilbert
Publikováno v:
Human mutation. 36(2)
The greatest interpretive challenge of modern medicine may be to functionally annotate the vast variation of human genomes. Demonstrating a proposed approach, we created a library of BRCA2 exon 27 shotgun-mutant plasmids including solitary and multip