Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anil G. Cashikar"'
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Neuroinflammation has been implicated in the pathogenesis of several neurologic and psychiatric disorders. Microglia are key drivers of neuroinflammation and, in response to different inflammatory stimuli, overexpress a proinflammatory signa
Externí odkaz:
https://doaj.org/article/9f3e33221a0543768775a4addf72830e
Autor:
Anil G. Cashikar, Danira Toral-Rios, David Timm, Johnathan Romero, Michael Strickland, Justin M. Long, Xianlin Han, David M. Holtzman, Steven M. Paul
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 4, Pp 100350- (2023)
Neuroinflammation, a major hallmark of Alzheimer’s disease and several other neurological and psychiatric disorders, is often associated with dysregulated cholesterol metabolism. Relative to homeostatic microglia, activated microglia express higher
Externí odkaz:
https://doaj.org/article/9641986798464afbbc1bf92bdeccf680
Autor:
Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, Wenjie Luo
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Genome-wide association studies of Alzheimer’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators of neuroinflammation
Externí odkaz:
https://doaj.org/article/8c787cef8c4b4f1ea698d77807c4d44c
Autor:
Fabia Filipello, Shih-Feng You, Farzaneh S. Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A. Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A. Minaya, Arun Renganathan, Anil G. Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K. Iyer, Marina Cella, Wendy H. Raskind, Laura Piccio, Celeste M. Karch
Publikováno v:
Acta Neuropathologica. 145:749-772
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer’s disease and frontotemporal dementia, while homozygous TREM2 mutations cause a rare leukody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1808ffc92b74dc4bbdd42e0fae1c83a4
https://doi.org/10.1007/s00401-023-02568-y
https://doi.org/10.1007/s00401-023-02568-y
Autor:
Anil G Cashikar, Danira Toral Rios, David Timm, Johnathan Romero, Justin M Long, Xianlin Han, David M. Holtzman, Steven M Paul
Neuroinflammation is a major hallmark of Alzheimer’s disease and several other neurological and psychiatric disorders and is often associated with dysregulated cholesterol metabolism. Relative to homeostatic microglia, activated microglia express h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf3444b4e03712c268ba5840396f6d10
https://doi.org/10.1101/2022.05.03.490494
https://doi.org/10.1101/2022.05.03.490494
Autor:
Anil G. Cashikar, Douglas F. Covey, Steven Mennerick, Kathiresan Krishnan, Charles F. Zorumski, Steven M. Paul, Yukitoshi Izumi
Publikováno v:
J Neurosci
Inflammatory cells, including macrophages and microglia, synthesize and release the oxysterol 25-hydroxycholesterol (25HC), which has antiviral and immunomodulatory properties. Here, we examined the effects of lipopolysaccharide (LPS), an activator o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ad67792d8a4c623b81608247bb81d2
https://europepmc.org/articles/PMC8660051/
https://europepmc.org/articles/PMC8660051/
Autor:
Gregory A. Petsko, Man Ying Wong, David M. Holtzman, Steven M. Paul, Patrick Sullivan, Li Gan, Mike Lewis, Douglas F. Covey, Yang Shi, Anil G. Cashikar, Jim Doherty, Mingxing Qian, Wenjie Luo, Shiaoching Gong
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e841f0ba2aedd2b60dd4b8c184108a0
https://doi.org/10.1002/alz.043097
https://doi.org/10.1002/alz.043097
Autor:
Shaiju K Vareed, Vadiraja B Bhat, Christopher Thompson, Vihas T Vasu, Damian Fermin, Hyungwon Choi, Chad J Creighton, Sitaram Gayatri, Ling Lan, Nagireddy Putluri, Gagan Singh Thangjam, Punit Kaur, Mohsen Shabahang, Judith G Giri, Alexey I Nesvizhskii, Alexander A A Asea, Anil G Cashikar, Arundhati Rao, James McLoughlin, Arun Sreekumar
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17177 (2011)
Pancreatic Adenocarcinoma (PDAC), the fourth highest cause of cancer related deaths in the United States, has the most aggressive presentation resulting in a very short median survival time for the affected patients. Early detection of PDAC is confou
Externí odkaz:
https://doaj.org/article/5c58f13c4990418e949ac96c90b1b6c2
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16550 (2011)
Molecular chaperones protect cells from the deleterious effects of protein misfolding and aggregation. Neurotoxicity of amyloid-beta (Aβ) aggregates and their deposition in senile plaques are hallmarks of Alzheimer's disease (AD). We observed that t
Externí odkaz:
https://doaj.org/article/afb1844c865c46d5a67fbc5f7e241779
Autor:
Anil G. Cashikar, Phyllis I. Hanson
Publikováno v:
PLOS ONE
PLoS ONE, Vol 14, Iss 7, p e0220007 (2019)
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0220007 (2019)
PLoS ONE
Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of disease. However, quantitative methods to enable elucidation of mechanisms underlying release are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd84f540b222c10ee8a41a8dcdc98018