Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Anil G Cashikar"'
Autor:
Yukitoshi Izumi, Kazuko A O'Dell, Anil G Cashikar, Steven M Paul, Douglas F Covey, Steven J Mennerick, Charles F Zorumski
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0304481 (2024)
Pro-inflammatory changes contribute to multiple neuropsychiatric illnesses. Understanding how these changes are involved in illnesses and identifying strategies to alter inflammatory responses offer paths to potentially novel treatments. We previousl
Externí odkaz:
https://doaj.org/article/0d8f6970cd0642b2afa9379787401a01
Autor:
Anil G Cashikar, Phyllis I Hanson
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0220007 (2019)
Extracellular vesicles (EVs) are thought to be important in cell-cell communication and have elicited extraordinary interest as potential biomarkers of disease. However, quantitative methods to enable elucidation of mechanisms underlying release are
Externí odkaz:
https://doaj.org/article/c4d589f890a5417c9f5ed04316e89c06
Autor:
Anil G Cashikar, Soomin Shim, Robyn Roth, Michael R Maldazys, John E Heuser, Phyllis I Hanson
Publikováno v:
eLife, Vol 3 (2014)
The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the topologically related processes of viral budding and cytokinesis, but how they accomplish this
Externí odkaz:
https://doaj.org/article/783c7127882840dca231f3c44d097230
Autor:
Shaiju K Vareed, Vadiraja B Bhat, Christopher Thompson, Vihas T Vasu, Damian Fermin, Hyungwon Choi, Chad J Creighton, Sitaram Gayatri, Ling Lan, Nagireddy Putluri, Gagan Singh Thangjam, Punit Kaur, Mohsen Shabahang, Judith G Giri, Alexey I Nesvizhskii, Alexander A A Asea, Anil G Cashikar, Arundhati Rao, James McLoughlin, Arun Sreekumar
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17177 (2011)
Pancreatic Adenocarcinoma (PDAC), the fourth highest cause of cancer related deaths in the United States, has the most aggressive presentation resulting in a very short median survival time for the affected patients. Early detection of PDAC is confou
Externí odkaz:
https://doaj.org/article/5c58f13c4990418e949ac96c90b1b6c2
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16550 (2011)
Molecular chaperones protect cells from the deleterious effects of protein misfolding and aggregation. Neurotoxicity of amyloid-beta (Aβ) aggregates and their deposition in senile plaques are hallmarks of Alzheimer's disease (AD). We observed that t
Externí odkaz:
https://doaj.org/article/afb1844c865c46d5a67fbc5f7e241779
Autor:
Fabia Filipello, Shih-Feng You, Farzaneh S. Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A. Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A. Minaya, Arun Renganathan, Anil G. Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K. Iyer, Marina Cella, Wendy H. Raskind, Laura Piccio, Celeste M. Karch
Publikováno v:
Acta Neuropathologica. 145:749-772
TREM2 is an innate immune receptor expressed by microglia in the adult brain. Genetic variation in the TREM2 gene has been implicated in risk for Alzheimer’s disease and frontotemporal dementia, while homozygous TREM2 mutations cause a rare leukody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1808ffc92b74dc4bbdd42e0fae1c83a4
https://doi.org/10.1007/s00401-023-02568-y
https://doi.org/10.1007/s00401-023-02568-y
Autor:
Anil G. Cashikar, Danira Toral-Rios, David Timm, Johnathan Romero, Michael Strickland, Justin M. Long, Xianlin Han, David M. Holtzman, Steven M. Paul
Publikováno v:
J Lipid Res
Neuroinflammation, a major hallmark of Alzheimer’s disease and several other neurological and psychiatric disorders, is often associated with dysregulated cholesterol metabolism. Relative to homeostatic microglia, activated microglia express higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1edb483797ea4ecddcb3d6f9aeeb5620
https://doi.org/10.1016/j.jlr.2023.100350
https://doi.org/10.1016/j.jlr.2023.100350
Autor:
Anil G Cashikar, Danira Toral Rios, David Timm, Johnathan Romero, Justin M Long, Xianlin Han, David M. Holtzman, Steven M Paul
Neuroinflammation is a major hallmark of Alzheimer’s disease and several other neurological and psychiatric disorders and is often associated with dysregulated cholesterol metabolism. Relative to homeostatic microglia, activated microglia express h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf3444b4e03712c268ba5840396f6d10
https://doi.org/10.1101/2022.05.03.490494
https://doi.org/10.1101/2022.05.03.490494
Autor:
Man Ying Wong, Yang Shi, Michael Lewis, James J. Doherty, Patrick Sullivan, David M. Holtzman, Douglas F. Covey, Wenjie Luo, Svitlana Tymchuk, Anna Amelianchik, Gregory A. Petsko, Anil G. Cashikar, Steven M. Paul, Mingxing Qian
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Genome-wide association studies of Alzheimer’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators of neuroinflammation in AD re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058fdbb965c203c8416fb0eaeee1e512
http://link.springer.com/article/10.1186/s12974-020-01869-3
http://link.springer.com/article/10.1186/s12974-020-01869-3
Autor:
Anil G. Cashikar, Douglas F. Covey, Steven Mennerick, Kathiresan Krishnan, Charles F. Zorumski, Steven M. Paul, Yukitoshi Izumi
Publikováno v:
J Neurosci
Inflammatory cells, including macrophages and microglia, synthesize and release the oxysterol 25-hydroxycholesterol (25HC), which has antiviral and immunomodulatory properties. Here, we examined the effects of lipopolysaccharide (LPS), an activator o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ad67792d8a4c623b81608247bb81d2
https://europepmc.org/articles/PMC8660051/
https://europepmc.org/articles/PMC8660051/