Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Anil G, Jegga"'
Autor:
S’Dravious A. DeVeaux, Sofiya Vyshnya, Katherine Propsom, Oluwabukola T. Gbotosho, Asem S. Singh, Robert Z. Horning, Mihika Sharma, Anil G. Jegga, Liang Niu, Edward A. Botchwey, Hyacinth I. Hyacinth
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
Cognitive deficit is a debilitating complication of sickle cell disease (SCD), with a multifactorial etiopathogenesis. Here we show that neuroinflammation and dysregulation in lipidomics and transcriptomics profiles are major underlying mechanisms of
Externí odkaz:
https://doaj.org/article/cf60ae327363473aad9f9b4733f4237f
Autor:
Darshini A. Desai, Akhil Baby, Kalyani Ananthamohan, Lisa C. Green, Mohammed Arif, Brittany C. Duncan, Mohit Kumar, Rohit R. Singh, Sheryl E. Koch, Sankar Natesan, Jack Rubinstein, Anil G. Jegga, Sakthivel Sadayappan
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100075- (2024)
Type 2 diabetes mellitus (T2DM) is a metabolic disease and comorbidity associated with several conditions, including cardiac dysfunction leading to heart failure with preserved ejection fraction (HFpEF), in turn resulting in T2DM-induced cardiomyopat
Externí odkaz:
https://doaj.org/article/dfbdc26c598344ae941d40c3723cf9bd
Autor:
Brad G. Kurowski, Amery Treble-Barna, Valentina Pilipenko, Lisa J. Martin, Anil G. Jegga, Aimee E. Miley, Nanhua Zhang, Anthony Fabio, Ranjit S. Chima, Anna-Lynne R. Adlam, Kenneth Kaufman, Michael J. Bell, Sue R. Beers, Stephen R. Wisniewski, Shari L. Wade, TBI Genetics and Environment Study Team
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
Introduction: There is significant unexplained variability in behavioral and executive functioning after pediatric traumatic brain injury (TBI). Prior research indicates that there are likely genetic contributions; however, current research is limite
Externí odkaz:
https://doaj.org/article/ef70d6c38f6e4c31b24d60c6d0614514
Autor:
Afshin Ebrahimpour, Manisha Ahir, Min Wang, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Sydney B. Montesi, Ganesh Raghu, Yohannes T. Ghebre
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease of unknown etiology. Currently, pirfenidone and nintedanib are the only FDA-approved drugs for the treatment of IPF and are now the standard of care. This is a signi
Externí odkaz:
https://doaj.org/article/3ce6a0a83e064759a2ff579276fe6229
Autor:
Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer, Iris Barshack, Shomron Ben-Horin, Igor Ulitsky, Anthony Beucher, Jorge Ferrer, Jeffrey S. Hyams, Lee A. Denson, Yael Haberman
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Ulcerative colitis (UC), Crohn’s disease (CD), and celiac disease are prevalent intestinal inflammatory disorders with nonsatisfactory therapeutic interventions. Analyzing patient data-driven cohorts can highlight disease pathways and new targets f
Externí odkaz:
https://doaj.org/article/175d48f8e9c64094a115fe7ffb8e26b5
Autor:
Yashar Zeighami, Trygve E Bakken, Thomas Nickl-Jockschat, Zeru Peterson, Anil G Jegga, Jeremy A Miller, Jay Schulkin, Alan C Evans, Ed S Lein, Michael Hawrylycz
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3002058 (2023)
Genes associated with risk for brain disease exhibit characteristic expression patterns that reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of disease risk genes provide a molecular-based signature, based on d
Externí odkaz:
https://doaj.org/article/e3161a5782d644bfb0511f353e3e4f28
Autor:
Pooja Khandelwal, Dana T Lounder, Allison Bartlett, Yael Haberman, Anil G. Jegga, Sudhir Ghandikota, Jane Koo, Nathan Luebbering, Daniel Leino, Sheyar Abdullah, Michaela Loveless, Phillip Minar, Kelly Lake, Bridget Litts, Rebekah Karns, Adam S. Nelson, Lee A. Denson, Stella M. Davies
Publikováno v:
Haematologica, Vol 108, Iss 7 (2023)
We performed transcriptomic analyses on freshly frozen (n=21) and paraffin-embedded (n=35) gastrointestinal (GI) biopsies from children with and without acute acute GI graft-versus-host disease (GvHD) to study differential gene expressions. We identi
Externí odkaz:
https://doaj.org/article/4fe814e572894a2582f0fd589687275a
Autor:
Yuan Li, Yi Zheng, Phuong Nguyen, Ting Wen, Anil G Jegga, Khalid W Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Fukun Guo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Cancer immunotherapy has taken center stage in cancer treatment. However, the current immunotherapies only benefit a small proportion of patients with cancer, necessitating better understanding of the mechanisms of tumor immune evasion and
Externí odkaz:
https://doaj.org/article/0a852aedcfe146eb8f5e7e1f97e9c4cf
Autor:
Vi Nguyen, Jacob Kravitz, Chao Gao, Marcelo L. Hochman, Dehao Meng, Dongbao Chen, Yunguan Wang, Anil G. Jegga, J Stuart Nelson, Wenbin Tan
Publikováno v:
Metabolites, Vol 13, Iss 9, p 983 (2023)
Port Wine Birthmarks (PWBs) are a congenital vascular malformation on the skin, occurring in 1–3 per 1000 live births. We have recently generated PWB-derived induced pluripotent stem cells (iPSCs) as clinically relevant disease models. The metaboli
Externí odkaz:
https://doaj.org/article/fb97ec88e52e441c8999d13348cecb6c
Autor:
Afshin Ebrahimpour, Min Wang, Li Li, Anil G. Jegga, Mark D. Bonnen, N. Tony Eissa, Ganesh Raghu, Soma Jyothula, Farrah Kheradmand, Nicola A. Hanania, Ivan O. Rosas, Yohannes T. Ghebre
Publikováno v:
Journal of Inflammation, Vol 18, Iss 1, Pp 1-14 (2021)
Abstract Introduction Idiopathic pulmonary fibrosis (IPF) is an orphan disease characterized by progressive loss of lung function resulting in shortness of breath and often death within 3–4 years of diagnosis. Repetitive lung injury in susceptible
Externí odkaz:
https://doaj.org/article/e4e7d799ccab4aaabac4af93292863d5