Data from A Novel Radiotracer to Image Glycogen Metabolism in Tumors by Positron Emission Tomography

Autor: Eric O. Aboagye, Roshan Agarwal, Ralph J. DeBerardinis, Robert Harris, Roberta Sala, Quang-Dé Nguyen, Anil Chandrashekran, Israt S. Alam, Laurence Carroll, Timothy H. Witney

The high rate of glucose uptake to fuel the bioenergetic and anabolic demands of proliferating cancer cells is well recognized and is exploited with 18F-2-fluoro-2-deoxy-d-glucose positron emission tomography (18F-FDG–PET) to image tumors clinicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac637b036e5c099dbf5dd9661bc34e91
https://doi.org/10.1158/0008-5472.c.6505989

Methylcellulose as a scaffold in the culture of liver-organoids for the potential of treating acute live failure

Autor: David C. Hay, Maesha Deheragoda, Ragai R. Mitry, Valeria Iansante, Sharon C. Lehec, Anil Chandrashekran, Celine Filippi, Emer Fitzpatrick, Tharindu Prema-chandra, Anil Dhawan, C. Starling

Publikováno v: Chandrashekran, A, Mitry, R R, Prema-chandra, T, Starling, C, Lehec, S, Iansante, V, Fitzpatrick, E, Filippi, C, Deheragoda, M, Hay, D & Dhawan, A 2018, ' Methylcellulose as a scaffold in the culture of liver-organoids for the potential of treating acute live failure ', Cell and Gene Therapy Insights, vol. 4, no. 11, pp. 1087-1103 . https://doi.org/10.18609/cgti.2018.111

Much progress has been made in understanding the development of human organs through advanced cellular and molecular techniques. Acute liver failure (ALF) in children is a life-threatening condition that relies on liver or hepatocyte transplantation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca81150672b1cda17675d59c61b5c15
https://www.pure.ed.ac.uk/ws/files/81524061/Chandrasekran.pdf

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo

Autor: Salamah Mohammad Alwahsh, Hassan Rashidi, Anil Dhawan, Maaria Ginai, David C. Hay, Philip N. Newsome, Anthony Callanan, Sharmin Alhaque, Mark Bradley, Hua Dong, Rute A. Tomaz, Anil Chandrashekran, Vasanthy Vigneswara, Bertrand Vernay, Nguyet-Thin Luu, Ludovic Vallier, Stuart J. Forbes, John M. Hallett

Publikováno v: Archives of Toxicology
Rashidi, H, Luu, N-T, Alwahsh, S M, Ginai, M, Alhaque, S, Dong, H, Tomaz, R A, Vernay, B, Vigneswara, V, Hallett, J M, Chandrashekran, A, Dhawan, A, Vallier, L, Bradley, M, Callanan, A, Forbes, S J, Newsome, P N & Hay, D C 2018, ' 3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo ', Archives of toxicology, vol. 92, no. 10, pp. 3117–3129 . https://doi.org/10.1007/s00204-018-2280-2

Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d535a65db0e9a4c8c4be2030d894a360
https://pubmed.ncbi.nlm.nih.gov/30446774

Generating Transgenic Mice by Lentiviral Transduction of Spermatozoa Followed by In Vitro Fertilization and Embryo Transfer

Autor: Robert Winston, Carol Readhead, N J Dibb, Anil Chandrashekran, Colin M. Casimir

Publikováno v: Lentiviral Vectors and Exosomes as Gene and Protein Delivery Tools ISBN: 9781493937516

Most transgenic technologies rely on the oocyte as a substrate for genetic modification. Transgenics animals are usually generated by the injection of the gene constructs (including lentiviruses encoding gene constructs or modified embryonic stem cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d62e4bd415b4151b30e2725b228fdd62
https://doi.org/10.1007/978-1-4939-3753-0_8

Cell-based liver therapies: past, present and future

Autor: Anil Chandrashekran, Valeria Iansante, Anil Dhawan

Publikováno v: Philosophical Transactions of the Royal Society B: Biological Sciences. 373:20170229

Liver transplantation represents the standard treatment for people with an end-stage liver disease and some liver-based metabolic disorders; however, shortage of liver donor tissues limits its availability. Furthermore, whole liver replacement elimin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05117f8e12b6c18f082713cf412a772
https://doi.org/10.1098/rstb.2017.0229