Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Anil Wipat"'
Autor:
Sepideh Sadegh, James Skelton, Elisa Anastasi, Andreas Maier, Klaudia Adamowicz, Anna Möller, Nils M. Kriege, Jaanika Kronberg, Toomas Haller, Tim Kacprowski, Anil Wipat, Jan Baumbach, David B. Blumenthal
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Large-scale disease-association data are widely used for pathomechanism mining, even if disease definitions used for annotation are mostly phenotype-based. Here, the authors show that this bias can lead to a blurred view on disease mechanisms, highli
Externí odkaz:
https://doaj.org/article/f94efe6e0688493fa30f8c9113b32eb9
Publikováno v:
Synthetic and Systems Biotechnology, Vol 8, Iss 1, Pp 97-106 (2023)
One challenge in the engineering of biological systems is to be able to recognise the cellular stress states of bacterial hosts, as these stress states can lead to suboptimal growth and lower yields of target products. To enable the design of genetic
Externí odkaz:
https://doaj.org/article/b0c7a745a1134e7e952d881f0d1cfc77
Autor:
Jianye Wang, Helen Mitrani, Anil Wipat, Polly Moreland, Jamie Haystead, Meng Zhang, Martyn Dade Robertson
Publikováno v:
Applied Sciences, Vol 14, Iss 7, p 2854 (2024)
The employment of Microbially Induced Calcium Carbonate Precipitation (MICP) is of increasing interest as a technique for environmentally sustainable soil stabilisation. Recent advancements in synthetic biology have allowed for the conception of a pr
Externí odkaz:
https://doaj.org/article/540c63897e434124861e2fc957cb467c
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-18 (2022)
Abstract Background Probabilistic functional integrated networks (PFINs) are designed to aid our understanding of cellular biology and can be used to generate testable hypotheses about protein function. PFINs are generally created by scoring the qual
Externí odkaz:
https://doaj.org/article/30c9ba23f6d14f70a0fb17d03bd77053
Autor:
Wei-Li Ling, Chinh Tran-To Su, Wai-Heng Lua, Joshua Yi Yeo, Jun-Jie Poh, Yuen-Ling Ng, Anil Wipat, Samuel Ken-En Gan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Interest in IgA as an alternative antibody format has increased over the years with much remaining to be investigated in relation to interactions with immune cells. Considering the recent whole antibody investigations showing significant dis
Externí odkaz:
https://doaj.org/article/0ddb0d87c4954560b8e53688e034f335
Autor:
Kotaro Mori, Kaho Fukui, Ryotaro Amatsu, Shu Ishikawa, Valeria Verrone, Anil Wipat, Wilfried J. J. Meijer, Ken-ichi Yoshida
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-8 (2022)
Abstract Background Geobacillus kaustophilus is a thermophilic Gram-positive bacterium. Methods for its transformation are still under development. Earlier studies have demonstrated that pLS20catΔoriT mobilized the resident mobile plasmids from Baci
Externí odkaz:
https://doaj.org/article/88ea913a38b84e7e8ff290962442659e
Autor:
Sepideh Sadegh, James Skelton, Elisa Anastasi, Judith Bernett, David B. Blumenthal, Gihanna Galindez, Marisol Salgado-Albarrán, Olga Lazareva, Keith Flanagan, Simon Cockell, Cristian Nogales, Ana I. Casas, Harald H. H. W. Schmidt, Jan Baumbach, Anil Wipat, Tim Kacprowski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
There is an unmet need for adaptable tools allowing biomedical researchers to employ network-based drug repurposing approaches for their individual use cases. Here, the authors close this gap with NeDRex, an integrative and interactive platform.
Externí odkaz:
https://doaj.org/article/215680eb37af47198ac9250590ddadb5
Autor:
Ling Juan Wu, Seoungjun Lee, Sungshic Park, Lucy E. Eland, Anil Wipat, Séamus Holden, Jeff Errington
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Bacteria can form wall-deficient variants, or L-forms, that divide by a simple mechanism that does not require the FtsZ-based cell division machinery. Here, Wu et al. study L-forms in microfluidic systems to show the importance of geometric effects f
Externí odkaz:
https://doaj.org/article/b613de00da4447ac896692750a3d0e6a
Autor:
Wei-Li Ling, Chinh Tran-To Su, Wai-Heng Lua, Jun-Jie Poh, Yuen-Ling Ng, Anil Wipat, Samuel Ken-En Gan
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Boosting the production of recombinant therapeutic antibodies is crucial in both academic and industry settings. In this work, we investigated the usage of varying signal peptides by antibody V-genes and their roles in recombinant transient productio
Externí odkaz:
https://doaj.org/article/7a012311347544eca4716b255396117e
Autor:
Mahmoud H Elbatreek, Sepideh Sadegh, Elisa Anastasi, Emre Guney, Cristian Nogales, Tim Kacprowski, Ahmed A Hassan, Andreas Teubner, Po-Hsun Huang, Chien-Yi Hsu, Paul M H Schiffers, Ger M Janssen, Pamela W M Kleikers, Anil Wipat, Jan Baumbach, Jo G R De Mey, Harald H H W Schmidt
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000885 (2020)
Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10 cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves impaired endothelium-dependent vasodilation through reactive oxygen s
Externí odkaz:
https://doaj.org/article/59e3c69f9059443b811c06990062c088