Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Anika Vear"'
Autor:
Anika Vear, Amlan Chakraborty, Farnaz Fahimi, Dorota Ferens, Robert Widdop, Chrishan S. Samuel, Tracey Gaspari, Peter M. van Endert, Siew Yeen Chai
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The enzyme, insulin regulated aminopeptidase (IRAP), is expressed in multiple immune cells such as macrophages, dendritic cells and T cells, where it plays a role in regulating the innate and adaptive immune response. There is a genetic association b
Externí odkaz:
https://doaj.org/article/1a133e6d51724eebb5123264fcc28940
Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker
Autor:
Anika Vear, Claudia Thalmann, Kristina Youngs, Natalie Hannan, Tracey Gaspari, Siew Yeen Chai
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract There is growing interest in the use of the enzyme, insulin regulated aminopeptidase (IRAP), as a biomarker for conditions such as cardio-metabolic diseases and ischemic stroke, with upregulation in its tissue expression in these conditions.
Externí odkaz:
https://doaj.org/article/f8537edf5e754a99b7f975ec160806c8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates. However, what makes IRA
Externí odkaz:
https://doaj.org/article/2ea2031e37894859aa5ff554b87b8308