Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Anika V. Prabhu"'
Autor:
Anika V. Prabhu, Insung Kang, Raffaella De Pace, Christopher A. Wassif, Hideji Fujiwara, Pamela Kell, Xuntian Jiang, Daniel S. Ory, Juan S. Bonifacino, Michael E. Ward, Forbes D. Porter
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis, a lipid essential
Externí odkaz:
https://doaj.org/article/fbf727df91264aa1910bff5cd9a48708
Autor:
Chi Wai Yip, Chung-Chau Hon, Kayoko Yasuzawa, Divya M. Sivaraman, Jordan A. Ramilowski, Youtaro Shibayama, Saumya Agrawal, Anika V. Prabhu, Callum Parr, Jessica Severin, Yan Jun Lan, Josée Dostie, Andreas Petri, Hiromi Nishiyori-Sueki, Michihira Tagami, Masayoshi Itoh, Fernando López-Redondo, Tsukasa Kouno, Jen-Chien Chang, Joachim Luginbühl, Masaki Kato, Mitsuyoshi Murata, Wing Hin Yip, Xufeng Shu, Imad Abugessaisa, Akira Hasegawa, Harukazu Suzuki, Sakari Kauppinen, Ken Yagi, Yasushi Okazaki, Takeya Kasukawa, Michiel de Hoon, Piero Carninci, Jay W. Shin
Publikováno v:
Yip, C W, Hon, C-C, Yasuzawa, K, Sivaraman, D M, Ramilowski, J A, Shibayama, Y, Agrawal, S, Prabhu, A V, Parr, C, Severin, J, Lan, Y J, Dostie, J, Petri, A, Nishiyori-Sueki, H, Tagami, M, Itoh, M, López-Redondo, F, Kouno, T, Chang, J-C, Luginbühl, J, Kato, M, Murata, M, Yip, W H, Shu, X, Abugessaisa, I, Hasegawa, A, Suzuki, H, Kauppinen, S, Yagi, K, Okazaki, Y, Kasukawa, T, de Hoon, M, Carninci, P & Shin, J W 2022, ' Antisense-oligonucleotide-mediated perturbation of long non-coding RNA reveals functional features in stem cells and across cell types ', Cell reports, vol. 41, no. 13, 111893 . https://doi.org/10.1016/j.celrep.2022.111893
Within the scope of the FANTOM6 consortium, we perform a large-scale knockdown of 200 long non-coding RNAs (lncRNAs) in human induced pluripotent stem cells (iPSCs) and systematically characterize their roles in self-renewal and pluripotency. We find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15a652955f06a58b1c97bd8ea86768f
https://vbn.aau.dk/da/publications/57100123-2566-469a-9534-0fbe9f544bdc
https://vbn.aau.dk/da/publications/57100123-2566-469a-9534-0fbe9f544bdc
Publikováno v:
Essays in Biochemistry
Recent efforts on the characterization of long non-coding RNAs (lncRNAs) revealed their functional roles in modulating diverse cellular processes. These include pluripotency maintenance, lineage commitment, carcinogenesis, and pathogenesis of various
Autor:
Isabelle M. Capell-Hattam, Anika V. Prabhu, Andrew J. Brown, Lydia Qian, Gene Hart-Smith, Laura J. Sharpe
Publikováno v:
J Biol Chem
Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well-understood. However, of the ∼20 enzymes in cholesterol biosynthesis, post-tra
Autor:
Insung Kang, Pamela Kell, Raffaella De Pace, Juan S. Bonifacino, Christopher A. Wassif, Michael E. Ward, Hideji Fujiwara, Xuntian Jiang, Forbes D. Porter, Anika V. Prabhu, Daniel S. Ory
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-12 (2021)
BMC Biology
BMC Biology
Background Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis, a lipid essential for cell
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 165:363-368
Cholesterol is essential for survival, but too much or too little can cause disease. Thus, cholesterol levels must be kept within close margins. 7-dehydrocholesterol reductase (DHCR7) is a terminal enzyme of cholesterol synthesis, and is essential fo
Autor:
Michael S. Fernandopulle, Connor H. Ludwig, Mariam A. Gachechiladze, Matthew T. Laurie, Jason Y. Hong, Mehrnoosh Abshari, Rajan Patel, Martin Kampmann, Michael E. Ward, Ruilin Tian, Diane Nathaniel, Anika V. Prabhu
Publikováno v:
Neuron, vol 104, iss 2
SUMMARYCRISPR/Cas9-based functional genomics have transformed our ability to elucidate mammalian cell biology. However, most previous CRISPR-based screens were conducted in cancer cell lines, rather than healthy, differentiated cells. Here, we descri
Publikováno v:
Journal of Biological Chemistry. 291:8363-8373
Cholesterol is detrimental to human health in excess but is also essential for normal embryogenesis. Hence, enzymes involved in its synthesis possess many layers of regulation to achieve balanced cholesterol levels. 7-Dehydrocholesterol reductase (DH
Publikováno v:
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1862(7)
Background The two control points of cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and squalene monooxygenase (SQLE) are known targets of the transcription factor sterol-regulatory element binding protein-2 (SREBP-2).
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1583
The development of gas chromatography/mass spectrometry (GC/MS) technology has improved the ease and efficiency with which sterols in biological samples can be analyzed. Its advantages include that it needs only a small amount of sample, a short anal