Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Anika Reinhardt"'
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 520-527 (2020)
Summary: A common strategy for multi-protein expression is to link genes by self-cleaving 2A peptide sequences. Yet, little is known how the 2A peptide-derived N-terminal proline or adjacent non-native residues introduced during cDNA cloning affects
Externí odkaz:
https://doaj.org/article/5dadd8675d3f43a082b26724c779169c
Autor:
Camilla Gustafsen, Ditte Olsen, Joachim Vilstrup, Signe Lund, Anika Reinhardt, Niels Wellner, Torben Larsen, Christian B. F. Andersen, Kathrin Weyer, Jin-ping Li, Peter H. Seeberger, Søren Thirup, Peder Madsen, Simon Glerup
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PCSK9 interacts with LDL receptor, causing its degradation, and consequently reduces the clearance of LDL. Here, Gustafsen et al. show that PCSK9 interacts with heparan sulfate proteoglycans and this binding favors LDLR degradation. Pharmacological i
Externí odkaz:
https://doaj.org/article/e6df4a8d335842ca8793c25354c164bc
Publikováno v:
Stem Cell Reports, Vol 14, Iss 3, Pp 520-527 (2020)
Stem Cell Reports
Stem Cell Reports
Summary A common strategy for multi-protein expression is to link genes by self-cleaving 2A peptide sequences. Yet, little is known how the 2A peptide-derived N-terminal proline or adjacent non-native residues introduced during cDNA cloning affects p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c358c453b05ff00e8a29878ad2affe0b
http://www.sciencedirect.com/science/article/pii/S2213671120300357
http://www.sciencedirect.com/science/article/pii/S2213671120300357
Autor:
Christian Brix Folsted Andersen, Jin-Ping Li, Joachim Vilstrup, Simon Glerup, Camilla Gustafsen, Peder Madsen, Søren Thirup, Anika Reinhardt, Kathrin Weyer, Torben Larsen, Niels Wellner, Signe Lund, Peter H. Seeberger, Ditte Olsen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Gustafsen, C, Olsen, D, Vilstrup, J, Lund, S, Reinhardt, A, Wellner, N, Larsen, T, Andersen, C B F, Weyer, K, Li, J-P, Seeberger, P H, Thirup, S, Madsen, P & Glerup, S 2017, ' Heparan sulfate proteoglycans present PCSK9 to the LDL receptor ', Nature Communications, vol. 8, no. 1, pp. 503 . https://doi.org/10.1038/s41467-017-00568-7
Nature Communications
Gustafsen, C, Olsen, D, Vilstrup, J, Lund, S, Reinhardt, A, Wellner, N, Larsen, T, Andersen, C B F, Weyer, K, Li, J-P, Seeberger, P H, Thirup, S, Madsen, P & Glerup, S 2017, ' Heparan sulfate proteoglycans present PCSK9 to the LDL receptor ', Nature Communications, vol. 8, no. 1, pp. 503 . https://doi.org/10.1038/s41467-017-00568-7
Nature Communications
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by inducing lysosomal degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b9c9a06332998a9d20f0f662317a56
http://link.springer.com/article/10.1038/s41467-017-00568-7
http://link.springer.com/article/10.1038/s41467-017-00568-7
Autor:
Peter H. Seeberger, Xiaoqiang Guo, Jana Mrázková, Franck Fieschi, You Yang, Hidenori Tanaka, Bernd Lepenies, Chakkumkal Anish, Frank Schuhmacher, Michaela Wimmerová, Christoph Rademacher, Daniele Leonori, Heung Sik Hahm, João T. Monteiro, Claney L. Pereira, Anika Reinhardt, Sandip Pasari, Sharavathi Guddehalli Parameswarappa, Mark K. Schlegel, Dan Grünstein, Jeyakumar Kandasamy, Guozhi Xiao, Andreas Geissner, Timo Johannssen, Sebastian Götze, Christopher E. Martin, Michel Thépaut
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (6), pp.1958-1967. ⟨10.1073/pnas.1800853116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (6), pp.1958-1967. ⟨10.1073/pnas.1800853116⟩
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (6), pp.1958-1967. ⟨10.1073/pnas.1800853116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (6), pp.1958-1967. ⟨10.1073/pnas.1800853116⟩
International audience; Interactions between glycans and glycan binding proteins are essential for numerous processes in all kingdoms of life. Glycan microarrays are an excellent tool to examine protein-glycan interactions. Here, we present a microbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f841ef747ad6725a82bf228c5c4ed8
https://pubmed.ncbi.nlm.nih.gov/30670663
https://pubmed.ncbi.nlm.nih.gov/30670663
Autor:
Anika Reinhardt, Uwe Groß, Daniel Varón Silva, Nahid Azzouz, Chakkumkal Anish, Peter H. Seeberger, Sebastian Götze, Yu‐Hsuan Tsai
Publikováno v:
Angewandte Chemie. 126:13920-13924
Geschatzte zwei Milliarden Menschen sind weltweit mit dem apikomplexen Parasiten Toxoplasma gondii infiziert, der die Ursache fur eine Reihe gesundheitlicher Probleme ist. So kann eine Primarinfektion wahrend der Schwangerschaft zum Tod des Fotus ode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::996ee3cde61c5f6a7de23a1c02107994
https://doi.org/10.1002/ange.201406706
https://doi.org/10.1002/ange.201406706
Publikováno v:
Journal of Virology. 88:2991-3003
All currently identified primary receptors of adeno-associated virus (AAV) are glycans. Depending on the AAV serotype, these carbohydrates range from heparan sulfate proteoglycans (HSPG), through glycans with terminal α2-3 or α2-6 sialic acids, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228de876d5286c0f34e31d21dc89d327
https://doi.org/10.1128/jvi.03371-13
https://doi.org/10.1128/jvi.03371-13
Autor:
Anika Reinhardt, Felix Broecker, Jonas Hanske, Chakkumkal Anish, Xiaoqiang Guo, Annette Wahlbrink, You Yang, Jonas Aretz, Peter H. Seeberger, Christoph Rademacher
Publikováno v:
ACS Chemical Biology. 9:867-873
Today, the process of selecting carbohydrate antigens as a basis for active vaccination and the generation of antibodies for therapeutic and diagnostic purposes is based on intuition combined with trial and error experiments. In efforts to establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758718c5de451c44fe4bc894917cc143
https://doi.org/10.1021/cb400925k
https://doi.org/10.1021/cb400925k
Autor:
Ieva Sutkeviciute, Anika Reinhardt, Anna Bernardi, Daniela Doknic, Donatella Potenza, Franck Fieschi, Pedro M. Nieto, Mark K. Schlegel, Cinzia Guzzi, Peter H. Seeberger, Morena Abramo
Publikováno v:
European Journal of Organic Chemistry. 2013:5303-5314
Glycomimetic molecules can be used to antagonize the action of carbohydrate-binding proteins (lectins) involved in biological processes of high relevance for human and plant disease. In this paper we describe the derivatization with appropriate linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c431583f15c72e26570f8407b6a0df2b
https://doi.org/10.1002/ejoc.201300236
https://doi.org/10.1002/ejoc.201300236
Autor:
Erika C. Crouch, You Yang, Anika Reinhardt, Marko Wehle, Chakkumkal Anish, Mark Santer, Yu Kang, Andreas Geissner, Peter H. Seeberger
Publikováno v:
Journal of Structural Biology
As a major player of the innate immune system, surfactant protein D (SP-D) recognizes and promotes elimination of various pathogens such as Gram-negative bacteria. SP-D binds to l-glycero-d-manno-heptose (Hep), a constituent of the partially conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e154bf5d9ebab826f1561595a40285
https://hdl.handle.net/11858/00-001M-0000-002B-558F-111858/00-001M-0000-002B-558E-311858/00-001M-0000-002D-BE5E-C11858/00-001M-0000-002A-F4EA-3
https://hdl.handle.net/11858/00-001M-0000-002B-558F-111858/00-001M-0000-002B-558E-311858/00-001M-0000-002D-BE5E-C11858/00-001M-0000-002A-F4EA-3
