Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Anika Klaus"'
Autor:
Sara Marie Ivasko, Kathleen Anders, Laura Grunewald, Michael Launspach, Anika Klaus, Silke Schwiebert, Peter Ruf, Horst Lindhofer, Holger N. Lode, Lena Andersch, Johannes H. Schulte, Angelika Eggert, Patrick Hundsdoerfer, Annette Künkele, Felix Zirngibl
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionDespite advances in treating high-risk neuroblastoma, 50-60% of patients still suffer relapse, necessitating new treatment options. Bispecific trifunctional antibodies (trAbs) are a promising new class of immunotherapy. TrAbs are heterodi
Externí odkaz:
https://doaj.org/article/4e199ae7fd1b49e29afc664c4e0bbbe6
Autor:
Annette Künkele, Angelika Eggert, Johannes H Schulte, Anika Klaus, Horst Lindhofer, Felix Zirngibl, Sara M Ivasko, Laura Grunewald, Silke Schwiebert, Peter Ruf, Kathy Astrahantseff, Lena Andersch, Holger N Lode, Kathleen Anders, Patrick Hundsdoerfer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Neuroblastoma is the most common extracranial solid tumor of childhood. Patients with high-risk disease undergo extremely aggressive therapy and nonetheless have cure rates below 50%. Treatment with the ch14.18 monoclonal antibody (dinutux
Externí odkaz:
https://doaj.org/article/3775a0fe4d3545de91f6ca37d90c877c
Autor:
Laura Grunewald, Tobias Lam, Lena Andersch, Anika Klaus, Silke Schwiebert, Annika Winkler, Anton Gauert, Anja I. Heeren-Hagemann, Kathy Astrahantseff, Filippos Klironomos, Alexander Thomas, Hedwig E. Deubzer, Anton G. Henssen, Angelika Eggert, Johannes H. Schulte, Kathleen Anders, Lutz Kloke, Annette Künkele
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chimeric antigen receptor (CAR) T cell performance against solid tumors in mouse models and clinical trials is often less effective than predicted by CAR construct selection in two-dimensional (2D) cocultures. Three-dimensional (3D) solid tumor archi
Externí odkaz:
https://doaj.org/article/36d3f87310c541579111c11eb4745bb7
Autor:
Lena Andersch, Josefine Radke, Anika Klaus, Silke Schwiebert, Annika Winkler, Elisa Schumann, Laura Grunewald, Felix Zirngibl, Carina Flemmig, Michael C. Jensen, Claudia Rossig, Antonia Joussen, Anton Henssen, Angelika Eggert, Johannes H. Schulte, Annette Künkele
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to date. Whereas unilat
Externí odkaz:
https://doaj.org/article/5def686206a34ba99dda7e4365b95db8
Autor:
Solin Ali, Karin Toews, Silke Schwiebert, Anika Klaus, Annika Winkler, Laura Grunewald, Lena Oevermann, Hedwig E. Deubzer, Alicia Tüns, Michael C. Jensen, Anton G. Henssen, Angelika Eggert, Johannes H. Schulte, Esther Schwich, Vera Rebmann, Alexander Schramm, Annette Künkele
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Chimeric antigen receptor (CAR) T cell efficacy against solid tumors is currently limited by several immune escape mechanisms, which may include tumor-derived extracellular vesicles. Advanced neuroblastoma is an aggressive childhood tumor without cur
Externí odkaz:
https://doaj.org/article/08d9b061f34547348113e50ddc8b2d15
Autor:
Ornela Sulejmani, Laura Grunewald, Lena Andersch, Silke Schwiebert, Anika Klaus, Annika Winkler, Kathy Astrahantseff, Angelika Eggert, Anton G. Henssen, Johannes H. Schulte, Kathleen Anders, Annette Künkele
Publikováno v:
Cancers, Vol 13, Iss 21, p 5489 (2021)
Chimeric antigen receptor (CAR) T cell therapy has emerged as a promising treatment strategy, however, therapeutic success against solid tumors such as neuroblastoma remains modest. Recurrence of antigen-poor tumor variants often ultimately results i
Externí odkaz:
https://doaj.org/article/075e1c199853426e8b3862f618c348e2
Autor:
Ana Textor, Laura Grunewald, Kathleen Anders, Anika Klaus, Silke Schwiebert, Annika Winkler, Maria Stecklum, Jana Rolff, Anton G. Henssen, Uta E. Höpken, Angelika Eggert, Johannes H. Schulte, Michael C. Jensen, Thomas Blankenstein, Annette Künkele
Publikováno v:
Cancers, Vol 13, Iss 5, p 1050 (2021)
Spacer or co-stimulatory components in chimeric antigen receptor (CAR) design influence CAR T cell effector function. Few preclinical mouse models optimally support CAR candidate pre-selection for clinical development. Here we use a model in which mu
Externí odkaz:
https://doaj.org/article/e25d843bc7594ca4a96d5b78d212c4bd
Autor:
Maria Stecklum, Michael C. Jensen, Kathleen Anders, Johannes H. Schulte, Silke Schwiebert, Ana Textor, Laura Grunewald, Jana Rolff, Thomas Blankenstein, Uta E. Höpken, Annika Winkler, Anton G. Henssen, Angelika Eggert, Annette Künkele, Anika Klaus
Publikováno v:
Cancers
Volume 13
Issue 5
Cancers, Vol 13, Iss 1050, p 1050 (2021)
Volume 13
Issue 5
Cancers, Vol 13, Iss 1050, p 1050 (2021)
Simple Summary Efficient trafficking and survival of CAR T cells within the hostile tumor microenvironment are important prerequisites for potent solid tumor attack that have not yet been achieved. We deployed monospecific murine instead of polyclona
Autor:
Solin Ali, Anton G. Henssen, Laura Grunewald, Anika Klaus, Johannes H. Schulte, Kathy Astrahantseff, Karin Toews, Angelika Eggert, Sebastian Ochsenreither, Silke Schwiebert, Annika Winkler, Dimitrios L. Wagner, Annette Künkele, Felix Zirngibl, Hedwig E. Deubzer
The immunosuppressive microenvironment in solid tumors is thought to form a barrier to the entry and efficacy of cell-based therapies such as chimeric antigen receptor (CAR) T cells. Combining CAR T cell therapy with checkpoint inhibitors has been de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a0276122e792a40584a88a23db7f7d
http://edoc.mdc-berlin.de/18885/7/18885suppl.zip
http://edoc.mdc-berlin.de/18885/7/18885suppl.zip
Autor:
Falk Hiepe, Gerd-Rüdiger Burmester, Tobias Alexander, Gabriela Riemekasten, Anika Klaus, D Abdirama, Elise Siegert, Caroline von Spee-Mayer, A. Rose, Jens Y Humrich, Andreas Radbruch, Birgit Sawitzki, Philipp Enghard
Publikováno v:
Annals of the Rheumatic Diseases. 75:1407-1415
Objectives Defects in regulatory T cell (Treg) biology have been associated with human systemic autoimmune diseases, such as systemic lupus erythematosus (SLE). However, the origin of such Treg defects and their significance in the pathogenesis and t