Výsledky vyhledávání - "Anika Jäkel"

Akademický článek

Targeting a cancer-specific LYPD3 glycoform for tumor therapy

Autor: Theresa Neumann, Evelyn Hartung, Johanna Gellert, Lisa Weiß, Manon Weiske, Naomi Kast, Stephanie Gurka, Sophie Marinoff, Anika Jäkel, Antje Danielczyk, Patrik Kehler

Publikováno v: Frontiers in Drug Discovery, Vol 3 (2023)

Introduction: One of the most drastic changes in cancer is the altered glycosylation of proteins and lipids, giving rise to truncated O-glycans like the Thomsen Friedenreich (TF) or Thomsen nouvelle (Tn) antigen, which are almost absent on normal cel

Externí odkaz: https://doaj.org/article/1642fa48651b41748ba0b68dfa45fd4f

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Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1

Autor: Konstantinos Anastassiadis, Annabell Bachem, Hans W. Mages, Richard A. Kroczek, Stephanie Gurka, Christoph Weise, Claudia Giesecke, Andreas Hutloff, Nele Reeg, Harald Weber, Volker Henn, Evelyn Hartung, Martina Becker, Anika Jäkel

Publikováno v: The Journal of Immunology. 194:1069-1079

Current subunit vaccines are incapable of inducing Ag-specific CD8+ T cell cytotoxicity needed for the defense of certain infections and for therapy of neoplastic diseases. In experimental vaccines, cytotoxic responses can be elicited by targeting of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c6f8bd58943b59ba4f8b62ab846d27
https://doi.org/10.4049/jimmunol.1401903

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Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα

Autor: Annabell Bachem, Stephanie Gurka, Martina Becker, Anika Jäkel, Steffen Güttler, Evelyn Hartung, Hans W. Mages, Ahmed Mora, Volker Henn, Richard A. Kroczek, Andreas Hutloff

Publikováno v: Frontiers in Immunology, Vol 5 (2014)
Frontiers in Immunology

In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor XCR1 is a lineage marker f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9c984e924048619486afe3b0fd8dfd
http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00326/full

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Abstract B123: In vivo targeting of antigen into XCR1+ DC combined with a potent amplification regime induces massive antigen-specific CD8+ T cell cytotoxicity

Autor: Anika Jäkel, Yi Yang, Richard A. Kroczek, Hans W. Mages, Evelyn Hartung, Stephanie Gurka

Publikováno v: Cancer Immunology Research. 4:B123-B123

Current immunization schemes do not induce potent CD8+ T cell cytotoxicity unless combined with viral boost regimes, which are not easily applicable in the human. We have recently shown that the chemokine receptor XCR1 is selectively expressed on ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7ecfcd17aeb2138c9208bc079c5bc80
https://doi.org/10.1158/2326-6074.cricimteatiaacr15-b123

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