Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anik Chaturbedi"'
Autor:
John Mann, Hamed Meshkin, Joel Zirkle, Xiaomei Han, Bradlee Thrasher, Anik Chaturbedi, Ghazal Arabidarrehdor, Zhihua Li
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Deep learning neural networks are often described as black boxes, as it is difficult to trace model outputs back to model inputs due to a lack of clarity over the internal mechanisms. This is even true for those neural networks designed to e
Externí odkaz:
https://doaj.org/article/8bd56b90bd8f40a79c1faefc6fdf06dc
Autor:
Joel Zirkle, Xiaomei Han, Rebecca Racz, Mohammadreza Samieegohar, Anik Chaturbedi, John Mann, Shilpa Chakravartula, Zhihua Li
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background During drug development, it is essential to gather information about the change of clinical exposure of a drug (object) due to the pharmacokinetic (PK) drug-drug interactions (DDIs) with another drug (precipitant). While many natu
Externí odkaz:
https://doaj.org/article/507ed657137542678b7cbb81c3c8525e
Autor:
Shilpa Chakravartula, Bradlee Thrasher, John Mann, Anik Chaturbedi, Xiaomei Han, Albert Dahan, Jeffry Florian, David Strauss, Zhihua Li
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 4, Pp n/a-n/a (2024)
Abstract Despite a rapid increase in pediatric mortality rate from prescription and illicit opioids, there is limited research on the dose‐dependent impact of opioids on respiratory depression in children, the leading cause of opioid‐associated d
Externí odkaz:
https://doaj.org/article/03329d7cf14840e6817eb278856c18f0
Autor:
Mohammadreza Samieegohar, James L. Weaver, Kristina E. Howard, Anik Chaturbedi, John Mann, Xiaomei Han, Joel Zirkle, Ghazal Arabidarrehdor, Rodney Rouse, Jeffry Florian, David G. Strauss, Zhihua Li
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:882-891
With the ongoing global pandemic of coronavirus disease 2019 (COVID-19), there is an urgent need to accelerate the traditional drug development process. Many studies identified potential COVID-19 therapies based on promising nonclinical data. However
Publikováno v:
Advanced Powder Technology. 32:2085-2096
This paper presents a predictive modeling approach of the high shear wet granulation process, quantifying the difference between the steady and induction granule growth behavior. The spatial heterogeneity in liquid binder distribution and shear rate
Autor:
John Mann, Mohammadreza Samieegohar, Anik Chaturbedi, Joel Zirkle, Xiaomei Han, S. Farzad Ahmadi, Amy Eshleman, Aaron Janowsky, Katherine Wolfrum, Tracy Swanson, Shelley Bloom, Albert Dahan, Erik Olofsen, Jeffry Florian, David G. Strauss, Zhihua Li
Publikováno v:
Clinical Pharmacology & Therapeutics, 112(5), 1020-1032. WILEY
In response to a surge of deaths from synthetic opioid overdoses, there have been increased efforts to distribute naloxone products in community settings. Prior research has assessed the effectiveness of naloxone in the hospital setting; however, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f88f489c8c0988eede7606bebd9ffb5
https://hdl.handle.net/1887/3572107
https://hdl.handle.net/1887/3572107
Autor:
Franklin E. Bettencourt, Rohit Ramachandran, Ioannis Paraskevakos, Anik Chaturbedi, Chaitanya Sampat, Marianthi G. Ierapetritou, Shantenu Jha, Yukteshwar Baranwal, Subhodh Karkala
Publikováno v:
Computers & Chemical Engineering. 119:128-142
The accurate modeling of the physics underlying particulate processes is complicated and requires significant computational capabilities to solve using particle-based models. In this work, a unidirectional multi-scale approach was used to model the h
Autor:
Anik Chaturbedi, Jay Poorna Reddy, Dilbir S. Bindra, Rohit Ramachandran, Bo Lang, Preetanshu Pandey, David Buckley
Publikováno v:
Powder Technology. 338:391-401
In this work, a population balance model has been developed and calibrated with experimental data to be used as a predictive tool to replace or reinforce experimental studies of high shear wet granulation. The system studied also involves dry binder
Publikováno v:
Computers & Chemical Engineering. 107:158-170
In order to solve high resolution PBMs to simulate real systems, with high accuracy and speed, a comprehensive and robust parallelization framework is needed. In this work, parallelization using just Message Passing Interface (MPI) and a more advance
Publikováno v:
Chemical Engineering Research and Design. 113:96-111
The properties of heteroaggregates (aggregates of particles that are different in various aspects such as size, surface charge) depend on the properties of the particles along with the initial relative concentration of the particles. In this article,