Výsledky vyhledávání - "Anikó Göblyös"

Eradication of meticillin-resistant Staphylococcus aureus from human skin by the novel LL-37-derived peptide P10 in four pharmaceutical ointments

Autor: Marion Rietveld, Jan W. Drijfhout, Alwin E. Adriaans, Peter H. Nibbering, Kirsten J. M. Schimmel, Robert A. Cordfunke, Suzan Commandeur, Sarah Zwart, Abdoelwaheb El Ghalbzouri, Elisabeth M. Haisma, Anikó Göblyös, Bep Ravensbergen, Jan den Hartigh, Remko van Leeuwen

Publikováno v: International Journal of Antimicrobial Agents, 54(5), 610-618. ELSEVIER

Skin bacterial colonization/infection is a frequent cause of morbidity in patients with chronic wounds and allergic/inflammatory skin diseases. This study aimed to develop a novel approach to eradicate meticillin-resistant Staphylococcus aureus (MRSA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1d989a7219782a5a850e344b063d61
http://hdl.handle.net/1887/122411

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Development of a Nose Cream Containing the Synthetic Antimicrobial Peptide P60.4Ac for Eradication of Methicillin-Resistant Staphylococcus aureus Carriage

Autor: Jan den Hartigh, Anikó Göblyös, Pieter S. Hiemstra, Kirsten J. M. Schimmel, Robert A. Cordfunke, A. Rob P. M. Valentijn, Jaap Oostendorp, Hee Lam Chan, Lorainne M. Fathers, Jan W. Drijfhout, Peter H. Nibbering

Publikováno v: Journal of Pharmaceutical Sciences, 102(10), 3539-3544

Methicillin-resistant Staphylococcus aureus (MRSA) infections are an increasing problem, and current treatment options are suboptimal. Nasal carriage of MRSA is a major risk factor for infection, but nasal eradication strategies are increasingly cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb730e05cdcebcc542dea6b5acbdcc2
https://doi.org/10.1002/jps.23695

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Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces

Autor: Jan den Hartigh, Jan W. Drijfhout, Anikó Göblyös, Elisabeth M. Haisma, Ronald W. A. L. Limpens, Peter H. Nibbering, Abdoelwaheb El Ghalbzouri, Jasmijn A. Schrumpf, Robert A. Cordfunke, Kirsten J. M. Schimmel, Bep Ravensbergen, Pieter S. Hiemstra, Alwin E Adriaans

Publikováno v: Antimicrobial Agents and Chemotherapy, 60(7), 4063-4072. AMER SOC MICROBIOLOGY
Antimicrobial Agents and Chemotherapy, 60(7), 4063-4072

We previously found the LL-37-derived peptide P60.4Ac to be effective against methicillin-resistant Staphylococcus aureus (MRSA) on human epidermal models (EMs). The goal of this study was to identify the preferred carrier for this peptide for topica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44cbca0d2fc41c35d076f2de67559b8f
https://hdl.handle.net/1887/99322

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Allosteric modulation of adenosine receptors

Autor: Ad P. IJzerman, Anikó Göblyös

Publikováno v: Purinergic Signalling

Allosteric ligands for G protein-coupled receptors (GPCRs) may alter receptor conformations induced by an orthosteric ligand. These modulators can thus fine-tune classical pharmacological responses. In this review we will describe efforts to synthesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789f384ac4e0b93524d704e8f57c918a

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Structure−Activity Relationships of New 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as Allosteric Enhancers of the A3 Adenosine Receptor

Autor: Johannes Brussee, Kenneth A. Jacobson, Kai Ye, Roberto Connestari, Anikó Göblyös, Zhan-Guo Gao, Sabrina Neves Santiago, Adriaan P. IJzerman

Publikováno v: Journal of Medicinal Chemistry. 49:3354-3361

1H-Imidazo[4,5-c]quinolin-4-amine derivatives have been synthesized as allosteric modulators of the human A3 adenosine receptor (AR). Structural modifications were made at the 4-amino and 2 positions. The compounds were tested in both binding and fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9315920e5b7f6c2451cf5d1db9b2ad
https://doi.org/10.1021/jm060086s

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Synthesis and Biological Evaluation of a New Series of 2,3,5-Substituted [1,2,4]-Thiadiazoles as Modulators of Adenosine A1 Receptors and Their Molecular Mechanism of Action

Autor: Johannes Brussee, Henk de Vries, Anikó Göblyös, Adriaan P. IJzerman

Publikováno v: Journal of Medicinal Chemistry. 48:1145-1151

We synthesized two series (7a-i and 8a-i) of 2,3,5-substituted [1,2,4]-thiadiazole analogues of SCH-202676 (7a, 2,3-diphenyl-5-N-methylimino-2H-[1,2,4]-thiadiazole) with emphasis on the N-imino substituent. Compounds 7a-g,i and 8a-g at a final concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7492113f3e0c84a89ccf46f1ba0c3d
https://doi.org/10.1021/jm049337s

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Ring-chain tautomerism of 2-aryl-substituted-hexahydropyrimidines and tetrahydroquinazolines

Autor: Ferenc Fülöp, Anikó Göblyös, László Lázár

Publikováno v: Tetrahedron. 58:1011-1016

2-Aryl-substituted-1-isopropyl- and 1-phenylhexahydropyrimidines and 3-isopropyl- and 3-phenyl-1,2,3,4-tetrahydroquinazolines proved to be ring-chain tautomeric mixtures in CDCl3 at 300 K, whereas only ring-closed tautomers could be detected for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee527749868a9eafcf0003c23baa3811
https://doi.org/10.1016/s0040-4020(01)01196-6

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Ring-Chain tautomerism of 2-aryl-substituted imidazolidines

Autor: Gábor Bernáth, Ferenc Fülöp, Anikó Göblyös, László Lázár, Ferenc Evanics

Publikováno v: Tetrahedron. 54:13639-13644

N-Methyl-, N-ethyl-, N-(n-propyl)-, N-(iso-propyl)- and N-phenyl-2-arylimidazolidines proved to be ring-chain tautomeric mixtures in CDCl3. The ratios of the open and ring forms in the tautomeric equilibria of these compounds is described by the equa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c448d11f6ee7c5868547d647e9997dd9
https://doi.org/10.1016/s0040-4020(98)00840-0

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Allosteric modulation of purine and pyrimidine receptors

Autor: Kenneth A. Jacobson, Adriaan P. IJzerman, Zhan-Guo Gao, Anikó Göblyös

Publikováno v: Advances in pharmacology (San Diego, Calif.). 61

Among the purine and pyrimidine receptors, the discovery of small molecular allosteric modulators has been most highly advanced for the A(1) and A(3) adenosine receptors (ARs). These AR modulators have allosteric effects that are structurally separat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899a58e51adbbd07be695afefc3d4010
https://pubmed.ncbi.nlm.nih.gov/21586360

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Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers

Autor: Annelien J.M. Zweemer, Dennis Verzijl, Anikó Göblyös, Adriaan P. IJzerman, Kai Ye, Kenneth A. Jacobson, Zhan-Guo Gao

Publikováno v: Biochemical pharmacology. 82(6)

Allosteric modulators for the G(i)-coupled A(3) adenosine receptor (AR) are of considerable interest as therapeutic agents and as pharmacological tools to probe various signaling pathways. In this study, we initially characterized the effects of seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a49a1c24db00c8bb14eeca3ff3623d
https://pubmed.ncbi.nlm.nih.gov/21718691

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