Evidence for light-entrainment-induced switching between depression-mania-relevant behaviors in mice

Autor: Jared W, Young, Zackary A, Cope, Benedetto, Romoli, Esther, Schrurs, Aniek, Joosen, Jordy, van Enkhuizen, Richard F, Sharp, Davide, Dulcis

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 44(10)

Developing novel therapeutics for bipolar disorder (BD) has been hampered by limited mechanistic knowledge how sufferers switch between mania and depression—how the same brain can switch between extreme states—described as the “holy grail” of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a468bd531e678acd1ad44c8c4a264c8
https://pubmed.ncbi.nlm.nih.gov/29520059

Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder.

Autor: Young JW; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA. jaredyoung@ucsd.edu.; Research Service, VA San Diego Healthcare System, San Diego, CA, USA. jaredyoung@ucsd.edu., Cope ZA; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Romoli B; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Schrurs E; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands., Aniek Joosen; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands., van Enkhuizen J; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Sharp RF; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Dulcis D; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA. ddulcis@ucsd.edu.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2018 Jul; Vol. 43 (8), pp. 1721-1731. Date of Electronic Publication: 2018 Feb 27.