Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Ania Wronski"'
Autor:
Jessica S. Elman, Thomas K. Ni, Kristen E. Mengwasser, Dexter Jin, Ania Wronski, Stephen J. Elledge, Charlotte Kuperwasser
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3435-3449.e5 (2019)
Summary: Comprehensive sequencing approaches have allowed for the identification of the most frequent contributors to cancer, known as drivers. They have also revealed a class of mutations in understudied, infrequently altered genes, referred to as
Externí odkaz:
https://doaj.org/article/e617fd7258c847d486aa6bcbaa90f6f9
Autor:
Jerrica L. Breindel, Adam Skibinski, Maja Sedic, Ania Wronski-Campos, Wenhui Zhou, Patricia J. Keller, Joslyn Mills, James Bradner, Tamer Onder, Charlotte Kuperwasser
Publikováno v:
Stem Cell Reports, Vol 9, Iss 3, Pp 943-955 (2017)
Organogenesis and tissue development occur through sequential stepwise processes leading to increased lineage restriction and loss of pluripotency. An exception to this appears in the adult human breast, where rare variant epithelial cells exhibit pl
Externí odkaz:
https://doaj.org/article/15112164c4b44467a40b1d0c89dc317d
Autor:
Wenhui Zhou, Thomas K. Ni, Ania Wronski, Benjamin Glass, Adam Skibinski, Andrew Beck, Charlotte Kuperwasser
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1302-1317 (2016)
Summary: Overabundance of Slug protein is common in human cancer and represents an important determinant underlying the aggressiveness of basal-like breast cancer (BLBC). Despite its importance, this transcription factor is rarely mutated in BLBC, an
Externí odkaz:
https://doaj.org/article/36f427dd51724d3ab6355886b0cb3d35
Autor:
Sarah Phillips, Aleix Prat, Maja Sedic, Theresa Proia, Ania Wronski, Sohini Mazumdar, Adam Skibinski, Stephanie H. Shirley, Charles M. Perou, Grace Gill, Piyush B. Gupta, Charlotte Kuperwasser
Publikováno v:
Stem Cell Reports, Vol 2, Iss 5, Pp 633-647 (2014)
Perturbations in stem cell activity and differentiation can lead to developmental defects and cancer. We use an approach involving a quantitative model of cell-state transitions in vitro to gain insights into how SLUG/SNAI2, a key developmental trans
Externí odkaz:
https://doaj.org/article/49bf3ae918ff4bb49ce7180791cc9d2e
Autor:
Lisa M Arendt, Jessica St Laurent, Ania Wronski, Silvia Caballero, Stephen R Lyle, Stephen P Naber, Charlotte Kuperwasser
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111442 (2014)
BACKGROUND:Although human breast development is mediated by hormonal and non-hormonal means, the mechanisms that regulate breast progenitor cell activity remain to be clarified. This limited understanding of breast progenitor cells has been due in pa
Externí odkaz:
https://doaj.org/article/e78d680dcaeb44ce966aa067bbfd1ec8
Publikováno v:
Journal of Developmental Biology, Vol 4, Iss 1, p 4 (2016)
During the formation of breast cancer, many genes become altered as cells evolve progressively from normal to a pre-malignant to a malignant state of growth. How mutations in genes lead to specific subtypes of human breast cancer is only partially un
Externí odkaz:
https://doaj.org/article/aefc18f847a94c2f9016281f4bef769c
Autor:
Chanel E Smart, Marjan E Askarian Amiri, Ania Wronski, Marcel E Dinger, Joanna Crawford, Dmitry A Ovchinnikov, Ana Cristina Vargas, Lynne Reid, Peter T Simpson, Sarah Song, Christiane Wiesner, Juliet D French, Richa K Dave, Leonard da Silva, Amy Purdon, Megan Andrew, John S Mattick, Sunil R Lakhani, Melissa A Brown, Stuart Kellie
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40742 (2012)
The protein tyrosine phosphatase receptor J, PTPRJ, is a tumor suppressor gene that has been implicated in a range of cancers, including breast cancer, yet little is known about its role in normal breast physiology or in mammary gland tumorigenesis.
Externí odkaz:
https://doaj.org/article/d5eaa5f72a81446caa82d85295dc8909
Autor:
Carl A Morrow, Eugene Valkov, Anna Stamp, Eve W L Chow, I Russel Lee, Ania Wronski, Simon J Williams, Justine M Hill, Julianne T Djordjevic, Ulrike Kappler, Bostjan Kobe, James A Fraser
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002957 (2012)
We have investigated the potential of the GTP synthesis pathways as chemotherapeutic targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal meningoencephalitis. We find that de novo GTP biosynthesis, but not the alterna
Externí odkaz:
https://doaj.org/article/33cc5f6ca2e241689d79d1cbab96ad8a
Autor:
Karen Cichowski, Charlotte Kuperwasser, Sandra S. McAllister, Ann H. Partridge, Alana Welm, Massimo Loda, Stephanie Guerra, Wenhui Zhou, Yoko S. DeRose, Miriam Enos, Thomas De Raedt, Clare Malone, Benjamin Dake, Zafira Castaño, Ania Wronski, Sarah Naomi Olsen
Ras Pathway Activation upon Rescue with wild-type or GAP-mutant DAB2IP and RASAL2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a54a28adda149675c3df7b91ef2cf2
https://doi.org/10.1158/2159-8290.22531870
https://doi.org/10.1158/2159-8290.22531870
Autor:
Karen Cichowski, Charlotte Kuperwasser, Sandra S. McAllister, Ann H. Partridge, Alana Welm, Massimo Loda, Stephanie Guerra, Wenhui Zhou, Yoko S. DeRose, Miriam Enos, Thomas De Raedt, Clare Malone, Benjamin Dake, Zafira Castaño, Ania Wronski, Sarah Naomi Olsen
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0306a17ef62ece3adb10c32821cbf453
https://doi.org/10.1158/2159-8290.22531882.v1
https://doi.org/10.1158/2159-8290.22531882.v1