Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ania M. Owsianka"'
Autor:
Vanessa M. Cowton, Ania M. Owsianka, Valeria Fadda, Ana Maria Ortega-Prieto, Sarah J. Cole, Jane A. Potter, Jessica K. Skelton, Nathan Jeffrey, Caterina Di Lorenzo, Marcus Dorner, Garry L. Taylor, Arvind H. Patel
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract HCV vaccine development is stymied by the high genetic diversity of the virus and the variability of the envelope glycoproteins. One strategy to overcome this is to identify conserved, functionally important regions—such as the epitopes of
Externí odkaz:
https://doaj.org/article/a3e8c908a1e3414390d0657b55f1aeda
Autor:
Claire L Donald, Benjamin Brennan, Stephanie L Cumberworth, Veronica V Rezelj, Jordan J Clark, Marli T Cordeiro, Rafael Freitas de Oliveira França, Lindomar J Pena, Gavin S Wilkie, Ana Da Silva Filipe, Christopher Davis, Joseph Hughes, Margus Varjak, Martin Selinger, Luíza Zuvanov, Ania M Owsianka, Arvind H Patel, John McLauchlan, Brett D Lindenbach, Gamou Fall, Amadou A Sall, Roman Biek, Jan Rehwinkel, Esther Schnettler, Alain Kohl
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005048 (2016)
BackgroundThe outbreak of Zika virus (ZIKV) in the Americas has transformed a previously obscure mosquito-transmitted arbovirus of the Flaviviridae family into a major public health concern. Little is currently known about the evolution and biology o
Externí odkaz:
https://doaj.org/article/aec56e53090642d5b80da2d66a065408
Autor:
Ana Maria Ortega-Prieto, Garry L. Taylor, Arvind H. Patel, Vanessa M. Cowton, Valeria Fadda, Nathan Jeffrey, Jessica Katy Skelton, Marcus Dorner, Ania M. Owsianka, Jane A. Potter, Sarah Cole, Caterina Di Lorenzo
Publikováno v:
NPJ Vaccines
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Funding: This work was supported by Medical Research Council grant MC_UU12014/2 and DPFS Grant MC_EX_G0801770 awarded to AHP, and by a studentship to VF from the Programma Master and Back, Regione Autonoma della Sardegna. This study was supported by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92be95aa864a19bdae828b3b6d4346e8
https://pubmed.ncbi.nlm.nih.gov/33420102
https://pubmed.ncbi.nlm.nih.gov/33420102
Autor:
Dorothea Bankwitz, Steven K. H. Foung, Ieva Vasiliauskaite, Arvind H. Patel, Thomas Krey, Joseph Marcotrigiano, Sarah Cole, Patrick England, Félix A. Rey, Ania M. Owsianka, Thomas Pietschmann, Abdul Ghafoor Khan
Publikováno v:
mBio
mBio, Vol 8, Iss 3 (2017)
mBio, 2017, 8 (3), pp.e00382-17. ⟨10.1128/mBio.00382⟩
mBio, Vol 8, Iss 3, p e00382-17 (2017)
mBio, Vol 8, Iss 3 (2017)
mBio, 2017, 8 (3), pp.e00382-17. ⟨10.1128/mBio.00382⟩
mBio, Vol 8, Iss 3, p e00382-17 (2017)
The hepatitis C virus (HCV) glycoprotein E2 is the major target of neutralizing antibodies and is therefore highly relevant for vaccine design. Its structure features a central immunoglobulin (Ig)-like β-sandwich that contributes to the binding site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46115abb57c9817644e9aa1c663e240b
https://eprints.gla.ac.uk/140242/1/140242.pdf
https://eprints.gla.ac.uk/140242/1/140242.pdf
Autor:
Nicole Walsh, Brendan A. Palmer, Arvind H. Patel, Ania M. Owsianka, Elizabeth Kenny-Walsh, Liam J. Fanning, Amruta S. Naik, Orla Crosbie, Ciaran J. O’Halloran
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0175349 (2017)
PLoS ONE
PLoS ONE
The humoral immune system responds to chronic hepatitis C virus (HCV) infection by producing neutralising antibodies (nAb). In this study we generated three HCV pseudoparticles in which E1E2 glycoprotein sequence was targeted by the host humoral immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe14800dd227d087fadda71168113d6f
https://doaj.org/article/7c0920706b6d4cb28d45f68a59c79b59
https://doaj.org/article/7c0920706b6d4cb28d45f68a59c79b59
Autor:
Jane A. Potter, David Matthews, Steven K. H. Foung, Garry L. Taylor, Arvind H. Patel, Patrick Lau, Ania M. Owsianka, Zhen-Yong Keck, Nathan Jeffery
Publikováno v:
Journal of Virology. 86:12923-12932
The E2 envelope glycoprotein of hepatitis C virus (HCV) binds to the host entry factor CD81 and is the principal target for neutralizing antibodies (NAbs). Most NAbs recognize hypervariable region 1 on E2, which undergoes frequent mutation, thereby a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd83a320a894aa1643f19693a228c0ed
https://doi.org/10.1128/jvi.02052-12
https://doi.org/10.1128/jvi.02052-12
Autor:
Sarah Cole, Allan G. N. Angus, Christina K. Markopoulou, James I. Dunlop, Deborah E. Gardner, Thomas Krey, Arvind H. Patel, Vanessa M. Cowton, Ania M. Owsianka
Publikováno v:
Journal of virology. 90(16)
Hepatitis C virus (HCV) enters cells via interactions with several host factors, a key one being that between the viral E2 envelope glycoprotein and the CD81 receptor. We previously identified E2 tryptophan residue 420 (W420) as an essential CD81-bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc666b632e357272ee753084cecf8ed
https://pubmed.ncbi.nlm.nih.gov/27279607
https://pubmed.ncbi.nlm.nih.gov/27279607
Autor:
John McLauchlan, Richard Adair, Paul Targett-Adams, Steeve Boulant, Kui Li, Ania M. Owsianka, Stanley M. Lemon, Allan G. N. Angus, Martin J. Scott, David R. McGivern, David A. Dalrymple, Takaji Wakita, Susan Graham, Arvind H. Patel, Reginald F. Clayton
Publikováno v:
The Journal of General Virology
The cellular DEAD-box protein DDX3 was recently shown to be essential for hepatitis C virus (HCV) replication. Prior to that, we had reported that HCV core binds to DDX3 in yeast-two hybrid and transient transfection assays. Here, we confirm by co-im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782c7ab29dca120d71010d3657d62502
https://doi.org/10.1099/vir.0.015909-0
https://doi.org/10.1099/vir.0.015909-0
Autor:
Steven K. H. Foung, Arvind H. Patel, Jonathan K. Ball, Richard Adair, Ania M. Owsianka, Alexander W. Tarr, Zhen-Yong Keck, Ta-Kai Li, Jeroen Witteveldt
Publikováno v:
The Journal of General Virology
Owsianka, A M, Tarr, A W, Keck, Z, Li, T-K, Witteveldt, J, Adair, R, Foung, S K H, Ball, J K & Patel, A H 2008, ' Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein ', Journal of General Virology, vol. 89, 3, pp. 653-9 . https://doi.org/10.1099/vir.0.83386-0
Owsianka, A M, Tarr, A W, Keck, Z, Li, T-K, Witteveldt, J, Adair, R, Foung, S K H, Ball, J K & Patel, A H 2008, ' Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein ', Journal of General Virology, vol. 89, 3, pp. 653-9 . https://doi.org/10.1099/vir.0.83386-0
The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein. Here, we report on their ability to inhibit infection b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01b8105435a8638d594da2917791a29
http://europepmc.org/articles/PMC2885755
http://europepmc.org/articles/PMC2885755
Autor:
Yoshiharu Matsuura, Hideki Tani, Kensuke Suzuki, Yasumasa Komoda, Tetsuo Yamashita, Kazuhito Fujiyama, Ania M. Owsianka, Arvind H. Patel, Norio Hayashi, Eiko Matsuo, Kohji Moriishi, Itsuki Hamamoto, Michael A. Whitt, Tatsuya Kanto
Publikováno v:
Journal of Virology. 81:8601-8612
Although in vitro replication of the hepatitis C virus (HCV) JFH1 clone of genotype 2a (HCVcc) has been developed, a robust cell culture system for the 1a and 1b genotypes, which are the most prevalent viruses in the world and resistant to interferon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d470213474fa88a93627c7747abe541c
https://doi.org/10.1128/jvi.00608-07
https://doi.org/10.1128/jvi.00608-07