Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ania Jankowska"'
Autor:
Yogen Saunthararajah, Tomas Radivoyevitch, Jaroslaw Maciejewski, Ramon Tiu, Mikkael A. Sekeres, Kory J. Engelke, Yonghua Ling, Kenneth Chan, Joseph Covey, Pramod Terse, Ali Tabarroki, Valeria Visconte, Xiaorong Gu, Quteba Ebrahem, Ania Jankowska, Reda Z. Mahfouz
Purpose: The cytidine analogs 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), produce a molecular epigenetic effect, depletion of DNA-methyltransferase 1 (DNMT1). This action is S-phase dependent. Hence, genetic factors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373c9f8453963162b9091ebec5310cce
https://doi.org/10.1158/1078-0432.c.6521568
https://doi.org/10.1158/1078-0432.c.6521568
Autor:
Yogen Saunthararajah, Tomas Radivoyevitch, Jaroslaw Maciejewski, Ramon Tiu, Mikkael A. Sekeres, Kory J. Engelke, Yonghua Ling, Kenneth Chan, Joseph Covey, Pramod Terse, Ali Tabarroki, Valeria Visconte, Xiaorong Gu, Quteba Ebrahem, Ania Jankowska, Reda Z. Mahfouz
PDF file - 297K, Figure S1: CDA mRNA expression in various human tissues. Figure S2: CDA mRNA expression in primary cancer cells. Figure S3: Incidence of MDS in the United States.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ec346f909f91c8916a876860d6b3b3
https://doi.org/10.1158/1078-0432.22449147
https://doi.org/10.1158/1078-0432.22449147
Autor:
Zachary P. Nearman, Ania Jankowska, Hadrian Szpurka, Jaroslaw P. Maciejewski, Lukasz P. Gondek, Ramon V. Tiu
Publikováno v:
Leukemia. 22:551-558
In myelodysplastic syndromes (MDS) increased chromosomal breaks point toward defects in DNA repair machinery including base excision repair (BER) pathway involved in handling of oxidative DNA damage. We investigated whether defects in this pathway ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d0be880c5328020895c486135be662
https://doi.org/10.1038/sj.leu.2405055
https://doi.org/10.1038/sj.leu.2405055
Autor:
Yonghua Ling, Kory J. Engelke, Kenneth K. Chan, Xiaorong Gu, Ania Jankowska, Pramod S. Terse, Tomas Radivoyevitch, Valeria Visconte, Ali Tabarroki, Mikkael A. Sekeres, Joseph M. Covey, Yogen Saunthararajah, Reda Z. Mahfouz, Quteba Ebrahem, Jaroslaw P. Maciejewski, Ramon V. Tiu
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 19(4)
Purpose: The cytidine analogs 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), produce a molecular epigenetic effect, depletion of DNA-methyltransferase 1 (DNMT1). This action is S-phase dependent. Hence, genetic factors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa16171d4d5d8577934bcd1983f7c278
https://pubmed.ncbi.nlm.nih.gov/23658458
https://pubmed.ncbi.nlm.nih.gov/23658458
Autor:
Kenneth K. Chan, Jaroslaw P. Maciejewski, Ania Jankowska, Kory J. Engelke, Pramod S. Terse, Ramon V. Tiu, Yonghua Ling, Reda Z. Mahfouz, Zhenbo Hu, Yogen Saunthararajah, Mikkael A. Sekeres, Quteba Ebrahem, Tomas Radivoyevitch, Joseph M. Covey
Publikováno v:
Nature Precedings.
In vivo, half-lives of cytidine analogues such as 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), are determined largely by cytidine deaminase (CDA), an enzyme that rapidly metabolizes these drugs into inactive uridine co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::017890d895fcbf51feed5d4f26f8f3c8
https://doi.org/10.1038/npre.2012.6971.1
https://doi.org/10.1038/npre.2012.6971.1
Autor:
Reda Mahfouz, Ania Jankowska, Quteba Ebrahem, Zhenbo Hu, Pramod Terse, Joseph Covey, Kenneth Chan, Yonghua Ling, Kory Engelke, Mikkael Sekeres, Ramon Tiu, Jaroslaw Maciejewski, Tomas Radivoyevitch, Yogen Saunthararajah
Publikováno v:
Nature Precedings
In vivo, half-lives of cytidine analogues such as 5-azacytidine and decitabine, used to treat myelodysplastic syndromes (MDS), are determined largely by cytidine deaminase (CDA), an enzyme that rapidly metabolizes these drugs into inactive uridine co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______984::10ab3478f2014949598875ccad88d56b
http://hdl.handle.net/10101/npre.2012.6971.1
http://hdl.handle.net/10101/npre.2012.6971.1
Autor:
Eric D. Hsi, Banu Gopalan, James C. Mulloy, Ania Jankowska, Juraj Bodo, Jaroslaw P. Maciejewski, Kathryn M Guinta, Yogen Saunthararajah, Kwok Peng Ng, Soledad Negrotto
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Leukemia
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Leukemia
The DNA hypomethylating drug decitabine maintains normal hematopoietic stem cell (HSC) self-renewal but induces terminal differentiation in acute myeloid leukemia (AML) cells. The basis for these contrasting cell fates, and for selective CpG hypometh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d165f08f124fdcc782fac9a265fea5
https://www.nature.com/articles/leu2011207
https://www.nature.com/articles/leu2011207
Autor:
Ania Jankowska, Ramon V. Tiu, Anjali S. Advani, Josephine Chan, Yogen Saunthararajah, Mikkael A. Sekeres, Nelli Bejanyan, Azra Raza, Jaroslaw P. Maciejewski, Lindsey Mooney, Matt Kalaycio
Publikováno v:
Cancer. 118(16)
BACKGROUND. Primary myelofibrosis (PMF) and overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders that share similar clinical features and molecular abnormalities, such as the Janus kinase 2 (JAK2) valine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e62db644c65bfb0e3299c3a40a890278
https://pubmed.ncbi.nlm.nih.gov/22180010
https://pubmed.ncbi.nlm.nih.gov/22180010
Autor:
Lukasz P. Gondek, Ying Jiang, Ramon V. Tiu, Monika Jasek, Jungwon Huh, Hideki Makishima, Michael A. McDevitt, Christine L. O'Keefe, Karl S. Theil, Ania Jankowska, Jaroslaw P. Maciejewski, Amit Verma
Publikováno v:
Genes, chromosomescancer. 49(4)
Deletion of the long arm of chromosome 20 is a common abnormality associated with myeloid malignancies. We characterized abnormalities of chromosome 20 as defined by metaphase cytogenetics (MC) in patients with myeloid neoplasms to define commonly de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e848c88df9326cde0fe4a5b0fcca23
https://pubmed.ncbi.nlm.nih.gov/20095039
https://pubmed.ncbi.nlm.nih.gov/20095039
Autor:
Ania Jankowska, Andrew E. Schade, Hadrian Szpurka, B.W. Lytle, J.P. Maciejewski, Gonzalo V. Gonzalez-Stawinski
Publikováno v:
The Journal of Heart and Lung Transplantation. 26:S132-S133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b92f1f8546b4f80d3ff28e3480ad7870
https://doi.org/10.1016/j.healun.2006.11.221
https://doi.org/10.1016/j.healun.2006.11.221