Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ania Alik"'
Autor:
Jessica Tittelmeier, Silke Druffel-Augustin, Ania Alik, Ronald Melki, Carmen Nussbaum-Krammer
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Fluorescence lifetime imaging microscopy combined with phasor analysis resolves seeding and aggregation dynamics of different α-synuclein polymorphs in a biosensor cell line.
Externí odkaz:
https://doaj.org/article/580f125619f44673af51731f51558500
Autor:
Melanie Barth, Mehtap Bacioglu, Niklas Schwarz, Renata Novotny, Janine Brandes, Marc Welzer, Sonia Mazzitelli, Lisa M. Häsler, Manuel Schweighauser, Thomas V. Wuttke, Deborah Kronenberg-Versteeg, Karina Fog, Malene Ambjørn, Ania Alik, Ronald Melki, Philipp J. Kahle, Derya R. Shimshek, Henner Koch, Mathias Jucker, Gaye Tanriöver
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-17 (2021)
Abstract Background Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of the initiation and pr
Externí odkaz:
https://doaj.org/article/09a2047b1a9c471c8a762f64027b5264
Autor:
Birger Victor Dieriks, Blake Highet, Ania Alik, Tracy Bellande, Taylor J Stevenson, Victoria Low, Thomas I-H Park, Jason Correia, Patrick Schweder, Richard L M Faull, Ronald Melki, Maurice A Curtis, Mike Dragunow
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277658 (2022)
Parkinson's disease (PD) is a progressive, neurodegenerative disorder characterised by the abnormal accumulation of α-synuclein (α-syn) aggregates. Central to disease progression is the gradual spread of pathological α-syn. α-syn aggregation is c
Externí odkaz:
https://doaj.org/article/5f2cfb2582e6453fbb3bc0f68763258f
Autor:
Charlotte Vajhøj, Benjamin Schmid, Ania Alik, Ronald Melki, Karina Fog, Bjørn Holst, Tina Charlotte Stummann
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0261536 (2021)
Inhibiting formation or promoting degradation of α-synuclein aggregates are among the therapeutical approaches under investigation as disease-modifying treatment strategies for Parkinson's disease. To support these developments, several in vitro mod
Externí odkaz:
https://doaj.org/article/a45dbc4724a14fff99017cc19f330a85
Autor:
Bouguechtouli Chafiaa, Rania Ghouil, Ania Alik, Dingli Florent, Loew Damarys, Theillet Francois-Xavier
The combined expression of a handful of pluripotency transcription factors (PluriTFs) in somatic cells can generate induced pluripotent stem cells (iPSCs). Here, we report the structural characterization of disordered regions contained in four import
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86dd91f40d5a5acf7850c1f63b21ee92
https://doi.org/10.1101/2023.03.05.531149
https://doi.org/10.1101/2023.03.05.531149
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceccf1fcf860e601fae638e6317caeef
https://doi.org/10.1007/978-1-0716-2597-2_23
https://doi.org/10.1007/978-1-0716-2597-2_23
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
The human α-synuclein protein, identified as one of the main markers of Parkinson's disease, is a 140-amino acid thermostable protein that can easily be overexpressed in E. coli. The purification protocol determines the ability of the protein to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d72a5106ac1630acb9d8e0b4990f48e
https://pubmed.ncbi.nlm.nih.gov/36310214
https://pubmed.ncbi.nlm.nih.gov/36310214
Autor:
Birger Victor Dieriks, Blake Highet, Ania Alik, Tracy Bellande, Taylor J. Stevenson, Victoria Low, Thomas I-H Park, Jason Correia, Patrick Schweder, Richard L. M. Faull, Ronald Melki, Maurice A. Curtis, Mike Dragunow
Parkinson’s disease (PD) is a progressive, neurodegenerative disorder characterised by the abnormal accumulation of α-synuclein (α-syn) aggregates. Central to disease progression is the gradual spread of pathological α-syn. α-syn aggregation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82eb8039f8b0c562f6604eb60ac2f5c4
https://doi.org/10.1101/2022.06.08.495286
https://doi.org/10.1101/2022.06.08.495286
Autor:
Wolfgang Bermel, François-Xavier Theillet, Ania Alik, Rania Ghouil, Manon Julien, Chafiaa Bouguechtouli, Sophie Zinn-Justin
Publikováno v:
Angewandte Chemie International Edition. 59:10411-10415
Abundant phosphorylation events rule the activity of nuclear proteins involved in gene regulation and DNA repair. These occur mostly on disordered regions of proteins, which often contain multiple phosphosites. Comprehensive and quantitative monitori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555b2137374073794ebad7b68efa3e49
https://doi.org/10.1002/anie.202002288
https://doi.org/10.1002/anie.202002288
Autor:
Qiao-Ling Chou, Ania Alik, François Marquier, Ronald Melki, François Treussart, Michel Simonneau
Endosomal transport and positioning are involved in establishing neuronal compartment architecture, dynamics and function, contributing to neuronal intracellular logistics. Furthermore, endo-lysosomal dysfunction has been identified as a common mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2999fb922e6c517b10774e6b779739
https://doi.org/10.1101/2021.05.15.444288
https://doi.org/10.1101/2021.05.15.444288