Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ania, Skowera"'
Autor:
Craig A. Beam, Lorraine Yeo, Mark Peakman, Martin Eichmann, Alyssa Woodwyk, Garry Dolton, Alka Saxena, Rossella Melchiotti, Sanjana Sood, Irma Pujol-Autonell, Andrew K. Sewell, Ania Skowera, Efthymios Fidanis, Katie Tungatt, Anna Lorenc, Susanne Heck
Publikováno v:
Journal of Clinical Investigation
Yeo, L, Woodwyk, A, Sood, S, Lorenc, A, Eichmann, M, Pujol-Autonell, I, Melchiotti, R, Skowera, A, Fidanis, E, Dolton, G M, Tungatt, K, Sewell, A K, Heck, S, Saxena, A, Beam, C A & Peakman, M 2018, ' Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes ', Journal of Clinical Investigation, vol. 128, no. 8, pp. 3460-3474 . https://doi.org/10.1172/JCI120555
Yeo, L, Woodwyk, A, Sood, S, Lorenc, A, Eichmann, M, Pujol-Autonell, I, Melchiotti, R, Skowera, A, Fidanis, E, Dolton, G M, Tungatt, K, Sewell, A K, Heck, S, Saxena, A, Beam, C A & Peakman, M 2018, ' Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes ', Journal of Clinical Investigation, vol. 128, no. 8, pp. 3460-3474 . https://doi.org/10.1172/JCI120555
In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells. In contrast, the disease relevance of β cell-reactiv
Autor:
Eddie A, James, Joana R F, Abreu, John W, McGinty, Jared M, Odegard, Yvonne E, Fillié, Claire N, Hocter, Slobodan, Culina, Kristin, Ladell, David A, Price, Aimon, Alkanani, Marynette, Rihanek, Lisa, Fitzgerald-Miller, Ania, Skowera, Cate, Speake, Peter, Gottlieb, Howard W, Davidson, F Susan, Wong, Bart, Roep, Roberto, Mallone
Publikováno v:
Diabetologia. 61(3)
Validated biomarkers are needed to monitor the effects of immune intervention in individuals with type 1 diabetes. Despite their importance, few options exist for monitoring antigen-specific T cells. Previous reports described a combinatorial approac
Autor:
James E. McLaren, Kristin Ladell, Emma Gostick, Robin R. Knight, Ania Skowera, David Price, Katherine K. Matthews, Martin Eichmann, Andrew K. Sewell, Deborah Kronenberg-Versteeg, Garry Dolton, Colin M. Dayan, Polly J. Bingley, Mark Peakman, Susanne Heck, Jake Powrie, John J. Miles
Publikováno v:
Diabetes. 64:916-925
Autoreactive CD8 T cells play a central role in the destruction of pancreatic islet β-cells that leads to type 1 diabetes, yet the key features of this immune-mediated process remain poorly defined. In this study, we combined high-definition polychr
Autor:
Helen E. Thomas, Andrew M. Lew, Ania Skowera, Kate L. Graham, Hyun Ja Ko, Robyn M. Sutherland, Jonathan Chee, Tara Catterall, Thomas W.H. Kay, Balasubramanian Krishnamurthy, Mark Peakman, Gaurang Jhala
Publikováno v:
The Journal of Immunology. 192:572-580
CD8+ T cells are critical in human type 1 diabetes and in the NOD mouse. In this study, we elucidated the natural history of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)-specific CD8+ T cells in NOD diabetes using MHC
Autor:
Mathew Clement, James A. Pearson, Stephanie Gras, Hugo A. van den Berg, Anya Lissina, Sian Llewellyn-Lacey, Mark D. Willis, Tamsin Dockree, James E. McLaren, Julia Ekeruche-Makinde, Emma Gostick, Neil P. Robertson, Jamie Rossjohn, Scott R. Burrows, David A. Price, F. Susan Wong, Mark Peakman, Ania Skowera, Linda Wooldridge
Publikováno v:
Clement, M, Pearson, J A, Gras, S, van den Berg, H A, Lissina, A, Llewellyn-Lacey, S, Willis, M D, Dockree, T, McLaren, J E, Ekeruche-Makinde, J, Gostick, E, Robertson, N P, Rossjohn, J, Burrows, S R, Price, D A, Wong, F S, Peakman, M, Skowera, A & Wooldridge, L 2016, ' Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies ', Scientific Reports, vol. 6, 35332 . https://doi.org/10.1038/srep35332
Clement, M, Pearson, J, Gras, S, van den Berg, H A, Lissina, A, Llewellyn-Lacey, S, Willis, M, Dockree, T, McLaren, J E, Ekeruche-Makinde, J, Gostick, E, Robertson, N P, Rossjohn, J, Burrows, S R, Price, D A, Wong, S, Peakman, M, Skowera, A & Wooldridge, L 2016, ' Targeted suppression of autoreactive CD8 + T-cell activation using blocking anti-CD8 antibodies ', Scientific Reports, vol. 6, 35332 . https://doi.org/10.1038/srep35332
Clement, M, Pearson, J, Gras, S, van den Berg, H A, Lissina, A, Llewellyn-Lacey, S, Willis, M, Dockree, T, McLaren, J E, Ekeruche-Makinde, J, Gostick, E, Robertson, N P, Rossjohn, J, Burrows, S R, Price, D A, Wong, S, Peakman, M, Skowera, A & Wooldridge, L 2016, ' Targeted suppression of autoreactive CD8 + T-cell activation using blocking anti-CD8 antibodies ', Scientific Reports, vol. 6, 35332 . https://doi.org/10.1038/srep35332
CD8+ T-cells play a role in the pathogenesis of autoimmune diseases such as multiple sclerosis and type 1 diabetes. However, drugs that target the entire CD8+ T-cell population are not desirable because the associated lack of specificity can lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::af32db4092e819f68f7f11ca97ae1d32
https://kclpure.kcl.ac.uk/ws/files/58649953/Targeted_suppression_of_CLEMENT_Accepted_9September2016_GOLD_VoR_CCBY.pdf
https://kclpure.kcl.ac.uk/ws/files/58649953/Targeted_suppression_of_CLEMENT_Accepted_9September2016_GOLD_VoR_CCBY.pdf
Autor:
Timothy Tree, Anthony E. Ting, Amy Raber, Robin R. Knight, Jef Pinxteren, James L. Reading, Robert J. Deans, Jennie H M Yang, Ania Skowera, Bart Vaes, Timothy E Allsopp, Sarah A. Busch, Shereen Sabbah
Publikováno v:
The Journal of Immunology. 190:4542-4552
A major goal of immunotherapy remains the control of pathogenic T cell responses that drive autoimmunity and allograft rejection. Adherent progenitor cells, including mesenchymal stromal cells (MSCs) and multipotent adult progenitor cells (MAPCs), re
Autor:
Andrea J. A. Schauenburg, David Price, David K. Cole, John J. Miles, Johanne M. Pentier, Andrew Trimby, Julia Ekeruche-Makinde, Hugo A. van den Berg, Ania Skowera, Mai Ping Tan, Jamie Rossjohn, Garry Dolton, Anna Marta Bulek, Tamsin Williams, Andrew K. Sewell, Kim M. Miles, Sian Llewellyn-Lacey, Mick Bailey, Linda Wooldridge, Mathew Clement, Pierre J. Rizkallah, Scott R. Burrows, Mark Peakman
Publikováno v:
Blood. 121:1112-1123
αβ-TCRs expressed at the CD8(+) T-cell surface interact with short peptide fragments (p) bound to MHC class I molecules (pMHCI). The TCR/pMHCI interaction is pivotal in all aspects of CD8(+) T-cell immunity. However, the rules that govern the outco
Autor:
Ania Skowera, Linda Wooldridge, Min Zhao, Robin R. Knight, Mark Peakman, Martin Eichmann, David K. Cole, Deborah Kronenberg, Andrew K. Sewell, Anna Marta Bulek, Guo Cai Huang
Publikováno v:
Diabetes
The end-stage immunopathology of type 1 diabetes resulting in β-cell destruction appears to be strongly dominated by cytotoxic CD8 T lymphocytes (CD8 T cells). However, the mechanism of cytotoxicity used by autoreactive CD8 T cells in the human sett
Autor:
David K. Cole, Anna M. Bulek, Garry Dolton, Andrea J. Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J. Miles, Mark Peakman, Linda Wooldridge, Pierre J. Rizkallah, Andrew K. Sewell
Publikováno v:
Cole, D K, Bulek, A M, Dolton, G, Schauenberg, A J, Szomolay, B, Rittase, W, Trimby, A, Jothikumar, P, Fuller, A, Skowera, A, Rossjohn, J, Zhu, C, Miles, J J, Peakman, M, Wooldridge, L, Rizkallah, P J & Sewell, A K 2016, ' Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity ', Journal of Clinical Investigation, vol. 126, no. 6, pp. 2191-2204 . https://doi.org/10.1172/JCI85679
Cole, D K, Bulek, A M, Dolton, G, Schauenberg, A J, Szomolay, B, Rittase, W, Trimby, A, Jothikumar, P, Fuller, A, Skowera, A, Rossjohn, J, Zhu, C, Miles, J J, Peakman, M, Wooldridge, L, Rizkallah, P J & Sewell, A K 2016, ' Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity ', The Journal of clinical investigation, vol. 126, no. 6, pp. 2191-2204 . https://doi.org/10.1172/JCI85679
Cole, D K, Bulek, A M, Dolton, G, Schauenberg, A J, Szomolay, B, Rittase, W, Trimby, A, Jothikumar, P, Fuller, A, Skowera, A, Rossjohn, J, Zhu, C, Miles, J J, Peakman, M, Wooldridge, L, Rizkallah, P J & Sewell, A K 2016, ' Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity ', The Journal of clinical investigation, vol. 126, no. 6, pp. 2191-2204 . https://doi.org/10.1172/JCI85679
The cross-reactivity of T cells with pathogen- and self-derived peptides has been implicated as a pathway involved in the development of autoimmunity. However, the mechanisms that allow the clonal T cell antigen receptor (TCR) to functionally engage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df844800cd29cee58353598117d44275
Autor:
Mathew, Clement, James A, Pearson, Stephanie, Gras, Hugo A, van den Berg, Anya, Lissina, Sian, Llewellyn-Lacey, Mark D, Willis, Tamsin, Dockree, James E, McLaren, Julia, Ekeruche-Makinde, Emma, Gostick, Neil P, Robertson, Jamie, Rossjohn, Scott R, Burrows, David A, Price, F Susan, Wong, Mark, Peakman, Ania, Skowera, Linda, Wooldridge
Publikováno v:
Scientific Reports
CD8+ T-cells play a role in the pathogenesis of autoimmune diseases such as multiple sclerosis and type 1 diabetes. However, drugs that target the entire CD8+ T-cell population are not desirable because the associated lack of specificity can lead to