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Model‐informed drug development for immuno‐oncology agonistic anti‐GITR antibody GWN323: Dose selection based on MABEL and biologically active dose

Autor: Yan Ji, Deborah Knee, Xinhui Chen, Anhthu Dang, Jennifer Mataraza, Babette Wolf, Sherwin K. B. Sy

Publikováno v: Clinical and Translational Science, Vol 15, Iss 9, Pp 2218-2229 (2022)

Abstract GWN323, an agonistic human anti‐GITR (glucocorticoid‐induced TNFR‐related protein) IgG1 antibody, was studied clinically as an immuno‐oncology therapeutic agent. A model‐based minimum anticipated biological effect level (MABEL) app

Externí odkaz: https://doaj.org/article/662da8bee895472795b46756cd7809b1

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A Common Polymorphism in the FADS1 Locus Links miR1908 to Low-Density Lipoprotein Cholesterol Through BMP1

Autor: Sébastien Soubeyrand, Thomas A. Lagace, Paulina Lau, Kaitlyn Beehler, Majid Nikpay, Ruth McPherson, AnhThu Dang

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 41:2252-2262

Objective: Leveraging microRNA-Seq data and the 1000 Genomes imputed genotypes, we identified rs174561 as a strong microRNA quantitative trait loci for circulating microRNA-1908-5p with higher miR-1908-5p and reduced LDL (low-density lipoprotein)-cho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0880e08a6b6c9734c049781723537de
https://doi.org/10.1161/atvbaha.121.316473

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A Novel Antibody-Drug Conjugate Targeting CCR7 in Hematologic Malignancies

Autor: Anhthu Dang, Deborah Knee, Cui Ying Wang, Feng Gao, Guoxun Liu, Sergio Briones, Michelle Coulson, Jessica Makofske, Keith Mansfield, May Liu, Tanya Mulvey, Emily K Meseck, Steve Woolfenden, Sean G Buchanan, David Steensma, Vasileios Askoxylakis

Publikováno v: Blood. 140:11564-11565

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d3e920fadb2ab0859e7a27380e4191b
https://doi.org/10.1182/blood-2022-159910

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A common polymorphism that protects from cardiovascular disease increases fibronectin processing and secretion

Autor: Sébastien Soubeyrand, Majid Nikpay, AnhThu Dang, Ruth McPherson, Paulina Lau

BackgroundFibronectin (FN1) is an essential regulator of homodynamic processes and tissue remodeling which has been proposed to contribute to atherosclerosis. Moreover, recent large scale genome wide association studies have linked common genetic var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d69af93c4c956ab3dbcb952cd14626bc
https://doi.org/10.1101/2021.03.09.434522

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Abstract 610: Functional Relationship of The CARS2 Locus to Coronary Artery Disease

Autor: AnhThu Dang, Sébastien Soubeyrand, Paulina Lau, Adam W. Turner, Ruth McPherson

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 38

In a recent meta-analysis of GWAS for cardiovascular disease (CAD) with imputation from 1000 Genomes (Nat Genet 2015), we identified 202 significant CAD associated variants (FDR q< 0.05) in 129 loci. Seven independent association signals were identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ca5e676ce37b8a5a8473e3c0bc77157
https://doi.org/10.1161/atvb.38.suppl_1.610

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Prenatal Therapy in Developmental Disorders: Drug Targeting via Intra-Amniotic Injection to Treat X-Linked Hypohidrotic Ectodermal Dysplasia

Autor: Katharina Hermes, AnhThu Dang, Pascal Schneider, Kenneth M. Huttner, Holm Schneider, Peter Krieg

Publikováno v: The Journal of investigative dermatology
Orphanet Journal of Rare Diseases
Journal of Investigative Dermatology, vol. 134, no. 12, pp. 2985-2987

Background Disorders that irremediably affect fetuses make early stage therapies desirable. X-linked hypohidrotic ectodermal dysplasia (XLHED), the most common inherited disorder of ectoderm development affecting the skin and its appendages, glands,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02082172a5fd7c5c5b18c87a2e90761d

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Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5/6 nephrectomized rats

Autor: Bhupinder Singh, Wei Ling Lau, Roshni G. Thakurta, Maria Bangash, Kasim Manekia, Javad Savoj, Anhthu Dang, Nosratola D. Vaziri, Mahyar Khazaeli

Publikováno v: Pharmacology research & perspectives, vol 6, iss 2
Lau, WL; Khazaeli, M; Savoj, J; Manekia, K; Bangash, M; Thakurta, RG; et al.(2018). Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5/6 nephrectomized rats.. Pharmacology research & perspectives, 6(2), e00385. doi: 10.1002/prp2.385. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2w49j4cb
Pharmacology Research & Perspectives

Tetrahydrocurcumin (THC) is the principal metabolite of curcumin and has antioxidant properties. In the present investigation, the effect of THC on renal and cardiovascular outcomes was studied in rats with chronic kidney disease (CKD). CKD rats were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54bda1c1bc14fb6635727afa372e831e
https://doi.org/10.1002/prp2.385

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