Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Anh Tuan Lormier"'
Publikováno v:
Current Medicinal Chemistry. 30
Background: NLS-3 or (R, R) enantiomer of phacetoperane (levophacetoperane) is the reverse ester of methylphenidate, a well-documented psychostimulant marketed for the treatment of attention-deficit/hyperactivity disorder (ADHD) since the end of 1950
Publikováno v:
Tetrahedron Letters. 53:6961-6964
A first palladium catalyzed cross-coupling amination with chiral auxiliaries at the two meso positions of diarylporphyrins was reported. We noticed that, the non-metallation of porphyrins and steric hinderance of the chiral auxiliary play an essentia
Publikováno v:
Tetrahedron Letters. 52:3175-3178
General access to 5,15-diarylporphyrins in two steps is described. Generalization of this approach to tetra-substituted porphyrins allows the reproducible preparation of compounds, in some cases with high yields for porphyrins, which can be used in p
Publikováno v:
Il Farmaco. 59:981-986
The study of the relative binding affinity (RBA) to the human alpha and beta estrogen receptors (ERs) of various 7-hydroxycoumarins substituted at 4- and 3,4- positions is weak and lacks in selectivity for both ERalpha and ERbeta. The 4-(4-hydroxyphe
Autor:
Anh Tuan Lormier, Sandrine Cojean, Philippe M. Loiseau, Zahra Abada, Bruno Figadère, Bernardin Akagah, Laurent Ferrié, Sébastien Pomel
Publikováno v:
European journal of medicinal chemistry. 67
Importance of heme in African trypanosomes, Leishmania sp. and Plasmodium sp. metabolisms justifies considering the potential of porphyrins and their precursors and derivatives as potential antiparasitic agents by interfering with heme metabolism. Co
Publikováno v:
The Journal of organic chemistry. 72(7)
Electron-poor 6-oxo-1-sulfonyl-1,6-dihydropyridine-3-carboxylates 1b−d undergo cross-Diels−Alder reactions with electron-rich dienes 4a−f under hyperbaric conditions, reacting either as dienophiles to yield normal-electron-demand (NED) cycloadd
Publikováno v:
ChemInform. 36
The study of the relative binding affinity (RBA) to the human α and β estrogen receptors (ERs) of various 7-hydroxycoumarins substituted at 4- and 3,4- positions is weak and lacks in selectivity for both ERα and ERβ. The 4-(4-hydroxyphenyl)-7-hyd
Publikováno v:
Tetrahedron Letters. 54:1900
Publikováno v:
Organic & Biomolecular Chemistry. 6:4494
A study comparing the chemical oxidation of drug candidates with cell-based metabolism (liver microsomes, hepatocytes) shows that biomimetic oxidation can replace the biological approach, thus allowing access to large quantities of metabolites, which
Publikováno v:
Scopus-Elsevier
New biacridinyl atropisomers were obtained from symmetric ligand 2,2'-dihydroxy-9,9'-biacridine (4), prepared from 9-chloro-2-methoxyacridine Alternative O-acylation and alkylation led to different polycycles and to a biacridinyl crown ether. The mol