Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Anh K. Lam"'
B cell focused transient immune suppression protocol for efficient AAV readministration to the liver
Autor:
Jyoti Rana, Roland W. Herzog, Maite Muñoz-Melero, Kentaro Yamada, Sandeep R.P. Kumar, Anh K. Lam, David M. Markusic, Dongsheng Duan, Cox Terhorst, Barry J. Byrne, Manuela Corti, Moanaro Biswas
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101216- (2024)
Adeno-associated virus (AAV) vectors are used for correcting multiple genetic disorders. Although the goal is to achieve lifelong correction with a single vector administration, the ability to redose would enable the extension of therapy in cases in
Externí odkaz:
https://doaj.org/article/dbfee83096ee41878357669ddf1b4522
Autor:
Junping Zhang, Dylan A. Frabutt, Matthew Chrzanowski, Ning Li, Lohra M. Miller, Jiahe Tian, Patrick L. Mulcrone, Anh K. Lam, Benjamin E. Draper, Martin F. Jarrold, Roland W. Herzog, Weidong Xiao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101206- (2024)
Self-complementary AAV vectors (scAAV) use a mutant inverted terminal repeat (mITR) for efficient packaging of complementary stranded DNA, enabling rapid transgene expression. However, inefficient resolution at the mITR leads to the packaging of mono
Externí odkaz:
https://doaj.org/article/ba0fb73ec32b4ab08090643c484cf170
Autor:
Patrick L. Mulcrone, Anh K. Lam, Dylan Frabutt, Junping Zhang, Matthew Chrzanowski, Roland W. Herzog, Weidong Xiao
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Although more adeno-associated virus AAV-based drugs enter the clinic, vector tissue tropism remains an unresolved challenge that limits its full potential despite that the tissue tropism of naturally occurring AAV serotypes can be altered b
Externí odkaz:
https://doaj.org/article/3995dcbcc1cb483fa7902a0c60257d86
Autor:
Anh K. Lam, Junping Zhang, Dylan Frabutt, Patrick L. Mulcrone, Lei Li, Lifan Zeng, Roland W. Herzog, Weidong Xiao
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 185-194 (2022)
Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With the skyrocketing rate of AAV research and the prevalence of many new engineered capsids being investigated in preclinical and clinical trials, capsid characterizati
Externí odkaz:
https://doaj.org/article/19ab892021054159a919044b17f3e279
Autor:
Junping Zhang, Ping Guo, Xiangping Yu, Dylan A. Frabutt, Anh K. Lam, Patrick L. Mulcrone, Matthew Chrzanowski, Jenni Firrman, Derek Pouchnik, Nianli Sang, Yong Diao, Roland W. Herzog, Weidong Xiao
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 852-861 (2022)
Recombinant adeno-associated virus (rAAV) vectors have been developed for therapeutic treatment of genetic diseases. Current rAAV vectors administered to affected individuals often contain vector DNA-related contaminants. Here we present a thorough m
Externí odkaz:
https://doaj.org/article/c6c9ec66ff5f44fb9ea07ac49a6b0bc3
Autor:
Anh K. Lam, Erika L. Moen, Jennifer Pusavat, Cassandra L. Wouters, Hannah Panlilio, Maya J. Ferrell, Matthew B. Houck, Daniel T. Glatzhofer, Charles V. Rice
Publikováno v:
ACS Omega, Vol 5, Iss 40, Pp 26262-26270 (2020)
Externí odkaz:
https://doaj.org/article/db0387a7984d4fab815dad43bd44950a
Autor:
Sandeep Kumar, Moanaro Biswas, Sreevani Arisa, Anh K. Lam, Annie Piñeros, Maite Melero Munoz, Reuben Kapur, Tsuneyasu Kaisho, Weidong Xiao, Dmitry Shayakhmetov, Cox Terhorst, Ype P. de Jong, Roland W. Herzog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa1d6663f18c981671a866b2e965f014
https://doi.org/10.2139/ssrn.4418617
https://doi.org/10.2139/ssrn.4418617
Autor:
Junping Zhang, Matthew Chrzanowski, Dylan A. Frabutt, Anh K. Lam, Patrick L. Mulcrone, Lei Li, Barbara A. Konkle, Carol H. Miao, Weidong Xiao
Publikováno v:
J Med Virol
Recombinant adeno-associated virus (rAAV) vectors carry a cassette of interest retaining only the inverted terminal repeats (ITRs) from the wild-type virus. Conventional rAAV production primarily uses a vector plasmid as well as helper genes essentia
Autor:
Erik L. Moen, Anh K. Lam, Jennifer Pusavat, Cassandra L. Wouters, Hannah Panlilio, Neda Heydarian, Zongkai Peng, Yunpeng Lan, Charles V. Rice
Publikováno v:
Chemical Biology & Drug Design. 101:489-499
Antibiotic resistance is a growing concern in the medical field. Drug-susceptible infections are often treated with β-lactam antibiotics, which bind to enzymes known as penicillin-binding proteins (PBPs). When the PBPs are disabled, the integrity of
Autor:
Cassandra L. Wouters, Neda Heydarian, Jennifer Pusavat, Hannah Panlilio, Anh K. Lam, Erika L. Moen, Robert E. Brennan, Charles V. Rice
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1865:184172