Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self

Autor: Kristina M. Geiger, Michael Manoharan, Rachel Coombs, Kathya Arana, Chan-Su Park, Angus Y. Lee, Nilabh Shastri, Ellen A. Robey, Laurent Coscoy

Publikováno v: Cell Reports, Vol 42, Iss 4, Pp 112317- (2023)

Summary: The endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP) plays a crucial role in shaping the peptide-major histocompatibility complex (MHC) class I repertoire and maintaining immune surveillance. While murine cytom

Externí odkaz: https://doaj.org/article/1eb0def2d54145d79e3f806380bb3bbe

Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection

Autor: Courtney K. Anderson, Emma C. Reilly, Angus Y. Lee, Laurent Brossay

Publikováno v: Cell Reports, Vol 27, Iss 2, Pp 537-548.e5 (2019)

Summary: The role of non-classical T cells during viral infection remains poorly understood. Using the well-established murine model of CMV infection (MCMV) and mice deficient in MHC class Ia molecules, we found that non-classical CD8+ T cells robust

Externí odkaz: https://doaj.org/article/b1db322df0134b0e8163917f59c0ece4

Deficiency in Galectin-3, -8, and -9 impairs immunity to chronicMycobacterium tuberculosisinfection but not acute infection with multiple intracellular pathogens

Autor: Huntly M. Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R. Johnson, Guillaume R. Golovkine, Claire E. Dodd, Erik Van Dis, Wandy L. Beatty, Shally R. Margolis, Teresa Repasy, Isaac Shaker, Angus Y. Lee, Russell E. Vance, Sarah A. Stanley, Nevan J. Krogan, Dan A. Portnoy, Bennett H. Penn, Jeffery S. Cox

Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-conta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2bb7ee444bae4e610492bf8e814abf6
https://doi.org/10.1101/2022.12.29.522180

Binary outcomes of enhancer activity underlie stable random monoallelic expression

Autor: Djem U. Kissiov, Alexander Ethell, Sean Chen, Natalie K. Wolf, Chenyu Zhang, Susanna M. Dang, Yeara Jo, Katrine N. Madsen, Ishan D. Paranjpe, Angus Y. Lee, Bryan Chim, Stefan A. Muljo, David H. Raulet

Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural kil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe4fd273b954900c9193ef9f401b76e
https://escholarship.org/uc/item/6wj2k8bw

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons

Autor: Shally R. Margolis, Victoria Chevée, Daniel A. Portnoy, Russell E. Vance, Moritz M. Gaidt, Dario S. Zamboni, K. Heran Darwin, Kristen C. Witt, Dmitri I. Kotov, Daisy X. Ji, Igor Kramnik, Alexander Louie, Nishimura Stephen, Katherine J. Chen, Angus Y. Lee, Harmandeep S. Dhaliwal

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
eLife
eLife, Vol 10 (2021)

Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriatel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4274f6f5360f1dcecd0bcafd5ed5d8e3
https://doi.org/10.7554/elife.67290