Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Angus Y Lee"'
Autor:
Huntly M Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R Johnson, Guillaume R Golovkine, Samantha L Bell, Claire E Dodd, Erik Van Dis, Wandy L Beatty, Shally R Margolis, Teresa Repasy, Isaac Shaker, Angus Y Lee, Russell E Vance, Sarah A Stanley, Robert O Watson, Nevan J Krogan, Daniel A Portnoy, Bennett H Penn, Jeffery S Cox
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011088 (2023)
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-conta
Externí odkaz:
https://doaj.org/article/bb529b2bbf75461d932dc89cb0aeb02a
Autor:
Justin L Roncaioli, Janet Peace Babirye, Roberto A Chavez, Fitty L Liu, Elizabeth A Turcotte, Angus Y Lee, Cammie F Lesser, Russell E Vance
Publikováno v:
eLife, Vol 12 (2023)
Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease driven by bacterial colonization of colonic intestinal epithelial cells. Vertebrates have evolved programmed cell death pathways that sense invasive enteric pathogens
Externí odkaz:
https://doaj.org/article/aaf98aa5e32244a883032ca3f3475318
Autor:
Djem U Kissiov, Alexander Ethell, Sean Chen, Natalie K Wolf, Chenyu Zhang, Susanna M Dang, Yeara Jo, Katrine N Madsen, Ishan Paranjpe, Angus Y Lee, Bryan Chim, Stefan A Muljo, David H Raulet
Publikováno v:
eLife, Vol 11 (2022)
Mitotically stable random monoallelic gene expression (RME) is documented for a small percentage of autosomal genes. We developed an in vivo genetic model to study the role of enhancers in RME using high-resolution single-cell analysis of natural kil
Externí odkaz:
https://doaj.org/article/9505cd27acaf469ab8f89ecc6921b8c0
Autor:
Daisy X Ji, Kristen C Witt, Dmitri I Kotov, Shally R Margolis, Alexander Louie, Victoria Chevée, Katherine J Chen, Moritz M Gaidt, Harmandeep S Dhaliwal, Angus Y Lee, Stephen L Nishimura, Dario S Zamboni, Igor Kramnik, Daniel A Portnoy, K Heran Darwin, Russell E Vance
Publikováno v:
eLife, Vol 10 (2021)
Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriatel
Externí odkaz:
https://doaj.org/article/a13a048f3761473cb07137e4ffca8ea4
Autor:
Patrick S Mitchell, Justin L Roncaioli, Elizabeth A Turcotte, Lisa Goers, Roberto A Chavez, Angus Y Lee, Cammie F Lesser, Isabella Rauch, Russell E Vance
Publikováno v:
eLife, Vol 9 (2020)
Bacteria of the genus Shigella cause shigellosis, a severe gastrointestinal disease that is a major cause of diarrhea-associated mortality in humans. Mice are highly resistant to Shigella and the lack of a tractable physiological model of shigellosis
Externí odkaz:
https://doaj.org/article/8044749c69d44811bb724f47313413ff
Autor:
Lívia H. Yamashiro, Stephen C. Wilson, Huntly M. Morrison, Vasiliki Karalis, Jing-Yi J. Chung, Katherine J. Chen, Helen S. Bateup, Moriah L. Szpara, Angus Y. Lee, Jeffery S. Cox, Russell E. Vance
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
STING is considered central to antiviral immunity via induction of type 1 interferons, but can also activate autophagy. Here the authors made two mice with different STING mutations that differentially affect these antiviral responses, and surprising
Externí odkaz:
https://doaj.org/article/ed627a1b0d98493cb43197c2fade35f0
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 537-548.e5 (2019)
Summary: The role of non-classical T cells during viral infection remains poorly understood. Using the well-established murine model of CMV infection (MCMV) and mice deficient in MHC class Ia molecules, we found that non-classical CD8+ T cells robust
Externí odkaz:
https://doaj.org/article/b1db322df0134b0e8163917f59c0ece4
Autor:
Huntly M. Morrison, Julia Craft, Rafael Rivera-Lugo, Jeffery R. Johnson, Guillaume R. Golovkine, Claire E. Dodd, Erik Van Dis, Wandy L. Beatty, Shally R. Margolis, Teresa Repasy, Isaac Shaker, Angus Y. Lee, Russell E. Vance, Sarah A. Stanley, Nevan J. Krogan, Dan A. Portnoy, Bennett H. Penn, Jeffery S. Cox
Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic carbohydrate sensors Galectin-3, -8, and -9 (Gal-3, Gal-8, and Gal-9) recognize damaged pathogen-conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2bb7ee444bae4e610492bf8e814abf6
https://doi.org/10.1101/2022.12.29.522180
https://doi.org/10.1101/2022.12.29.522180
Autor:
Kristina M. Geiger, Michael Manoharan, Rachel Coombs, Chan-su Park, Angus Y. Lee, Nilabh Shastri, Ellen A. Robey, Laurent Coscoy
SummaryThe endoplasmic reticulum aminopeptidase associated with antigen presentation (ERAAP) plays a crucial role in shaping the peptide-MHC I repertoire and maintaining immune surveillance. While murine cytomegalovirus (MCMV) has multiple strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::617275036fe975998930efbaeb15e98a
https://doi.org/10.1101/2022.08.23.504566
https://doi.org/10.1101/2022.08.23.504566
Autor:
Kristina M. Geiger, Michael Manoharan, Rachel Coombs, Kathya Arana, Chan-Su Park, Angus Y. Lee, Nilabh Shastri, Ellen A. Robey, Laurent Coscoy
Publikováno v:
Cell Reports. 42:112317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c51c11abac4077938d14124614eb1e0d
https://doi.org/10.1016/j.celrep.2023.112317
https://doi.org/10.1016/j.celrep.2023.112317