Zobrazeno 1 - 10
of 3 482
pro vyhledávání: '"Angus W"'
Autor:
Silvia Liu, Alan F. Zahorchak, Steven F. Dobrowolski, Diana M. Metes, Angus W. Thomson, Hossam A. Abdelsamed
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract During differentiation of precursor cells into their destination cell type, cell fate decisions are enforced by a broad array of epigenetic modifications, including DNA methylation, which is reflected by the transcriptome. Thus, regulatory d
Externí odkaz:
https://doaj.org/article/792445a8ea6e476e856df477eeebc201
Autor:
Yuxi Fan, Ye Xu, Zhi Huo, Hedong Zhang, Longkai Peng, Xin Jiang, Angus W. Thomson, Helong Dai, Sihan Zhou, Xiuyuan Hao
Publikováno v:
Chinese Medical Journal, Vol 137, Iss 14, Pp 1663-1673 (2024)
Abstract. Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily. As an amplifier of the inflammatory response, TREM-1 is mainly involved in the production of inflammatory mediators and the regulation
Externí odkaz:
https://doaj.org/article/abed80ddde3b4748a010c2a2a4635cdf
Autor:
Yan Cui, Chao Chen, Zhouqi Tang, Wenjia Yuan, Kaiye Yue, Pengcheng Cui, Xia Qiu, Hedong Zhang, Tengfang Li, Xuejing Zhu, Jiadi Luo, Siyu Sun, Yaguang Li, Chen Feng, Longkai Peng, Xubiao Xie, Yong Guo, Yixin Xie, Xin Jiang, Zhongquan Qi, Angus W. Thomson, Helong Dai
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-14 (2024)
Abstract The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, and counteracting inflammation. Its role in renal injury,
Externí odkaz:
https://doaj.org/article/5dcef436c25a4094a549c26ef22f7fa5
Autor:
Tao Zhang, Ramez Wahib, Dimitra E. Zazara, Jöran Lücke, Ahmad Mustafa Shiri, Jan Kempski, Lilan Zhao, Theodora Agalioti, Andres Pablo Machicote, Olympia Giannou, Ioannis Belios, Rongrong Jia, Siwen Zhang, Joseph Tintelnot, Hannes Seese, Julia Kristin Grass, Baris Mercanoglu, Louisa Stern, Pasquale Scognamiglio, Mohammad Fard-Aghaie, Philipp Seeger, Jonas Wakker, Marius Kemper, Benjamin Brunswig, Anna Duprée, Panagis M. Lykoudis, Anastasia Pikouli, Emmanouil Giorgakis, Pablo Stringa, Natalia Lausada, Maria Virginia Gentilini, Gabriel E. Gondolesi, Kai Bachmann, Philipp Busch, Rainer Grotelüschen, Ioannis C. Maroulis, Petra C. Arck, Ryosuke Nakano, Angus W. Thomson, Tarik Ghadban, Michael Tachezy, Nathaniel Melling, Eike-Gert Achilles, Victor G. Puelles, Felix Nickel, Thilo Hackert, Oliver Mann, Jakob R. Izbicki, Jun Li, Nicola Gagliani, Samuel Huber, Anastasios D. Giannou
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTMetastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formati
Externí odkaz:
https://doaj.org/article/3cee1dcf7a0d46038cb4bbb3cfb81bcf
Autor:
A. David Redish, Samantha V. Abram, Paul J. Cunningham, Anneke A. Duin, Romain Durand-de Cuttoli, Rebecca Kazinka, Adrina Kocharian, Angus W. MacDonald, Brandy Schmidt, Neil Schmitzer-Torbert, Mark J. Thomas, Brian M. Sweis
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Computationally parallel ‘change-of-mind’ tasks in mice, rats and humans are analysed and demonstrate that sensitivity to sunk costs during re-evaluation depends on the awareness of time spent and remaining.
Externí odkaz:
https://doaj.org/article/453761f205584e83b5c10477951d5d8f
Autor:
Anastasios D. Giannou, Jan Kempski, Tao Zhang, Jöran Lücke, Ahmad Mustafa Shiri, Dimitra E. Zazara, Ioannis Belios, Andres Machicote, Philipp Seeger, Theodora Agalioti, Joseph Tintelnot, Adrian Sagebiel, Miriam Tomczak, Lennart Bauditz, Tanja Bedke, Lorenz Kocheise, Baris Mercanoglu, Mohammad Fard-Aghaie, Emmanouil Giorgakis, Panagis M. Lykoudis, Anastasia Pikouli, Julia-Kristin Grass, Ramez Wahib, Jan Bardenhagen, Benjamin Brunswig, Asmus Heumann, Tarik Ghadban, Anna Duprée, Michael Tachezy, Nathaniel Melling, Petra C. Arck, Pablo Stringa, Maria Virginia Gentilini, Gabriel E. Gondolesi, Ryosuke Nakano, Angus W. Thomson, Daniel Perez, Jun Li, Oliver Mann, Jakob R. Izbicki, Nicola Gagliani, Ioannis C. Maroulis, Samuel Huber
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundThe immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). Howeve
Externí odkaz:
https://doaj.org/article/f1277168178b412eb2f6bc3aef5b86d5
Autor:
Kazuki Sasaki, Mouhamad Al Moussawy, Khodor I. Abou-Daya, Camila Macedo, Amira Hosni-Ahmed, Silvia Liu, Mariam Juya, Alan F. Zahorchak, Diana M. Metes, Angus W. Thomson, Fadi G. Lakkis, Hossam A. Abdelsamed
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Human activated memory CD8 T cells develop a non-cytotoxic function and influence the fate of autologous naïve CD8 T cells where they acquire an activated/memory state and a hybrid state between naïve and activated memory.
Externí odkaz:
https://doaj.org/article/44b4b05e7ad3482c93e236ebb6b01b84
Autor:
Ben J. Fisher, Connor J. Shiggins, Angus W. Naylor, Lauren D. Rawlins, Guy D. Tallentire, Floor van den Heuvel, Craig Poku, Maribel I. García-Ibáñez, Margot Debyser, Jack Buckingham
Publikováno v:
Communications Earth & Environment, Vol 2, Iss 1, Pp 1-4 (2021)
The pandemic has badly affected the most diverse career stage in UK Earth sciences: early career researchers. Disrupted careers must be rescued with contingency plans, remote networks, a focus on mental health and mentor support if we are to retain d
Externí odkaz:
https://doaj.org/article/2d2f14cd19da43528480a2fb16c5177f
Neuroprotection against ischemic stroke requires a specific class of early responder T cells in mice
Autor:
Wei Cai, Ligen Shi, Jingyan Zhao, Fei Xu, Connor Dufort, Qing Ye, Tuo Yang, Xuejiao Dai, Junxuan Lyu, Chenghao Jin, Hongjian Pu, Fang Yu, Sulaiman Hassan, Zeyu Sun, Wenting Zhang, T. Kevin Hitchens, Yejie Shi, Angus W. Thomson, Rehana K. Leak, Xiaoming Hu, Jun Chen
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Immunomodulation holds therapeutic promise against brain injuries, but leveraging this approach requires a precise understanding of mechanisms. We report that CD8+CD122+CD49dlo T regulatory-like cells (CD8+ TRLs) are among the earliest lymphocytes to
Externí odkaz:
https://doaj.org/article/6faa48ac6514477ea85a1c9ae8ac6563
Autor:
Qian Lu, Wentong Zhang, Hailang Yan, Negar Mansouri, Onur Tanglay, Karol Osipowicz, Angus W. Joyce, Isabella M. Young, Xia Zhang, Stephane Doyen, Michael E. Sughrue, Chuan He
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2022)
ObjectiveDespite its prevalence, insomnia disorder (ID) remains poorly understood. In this study, we used machine learning to analyze the functional connectivity (FC) disturbances underlying ID, and identify potential predictors of treatment response
Externí odkaz:
https://doaj.org/article/eb90fc462f474ba89d8bf26336b9f1f9