Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Angus T. De Souza"'
Autor:
Xudong Dai, Angus T De Souza, Hongyue Dai, David L Lewis, Chang-kyu Lee, Andy G Spencer, Hans Herweijer, Jim E Hagstrom, Peter S Linsley, Douglas E Bassett, Roger G Ulrich, Yudong D He
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 3, p e30 (2007)
Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in ca
Externí odkaz:
https://doaj.org/article/4bbedddb2b9044bea8ea3ca7ee5ebb5e
Autor:
Angus T. De Souza, Tom W. Reppen, Xudong Dai, Hans Herweijer, Paula L. Roesch, Michelle J. Caguyong, Sherri Bloomer, Roger G. Ulrich, A.M. Menzie, Peter S. Linsley, James E. Hagstrom, David L. Lewis, Andrew G Spencer, Yudong He, Jon A. Wolff
Publikováno v:
Nucleic Acids Research
RNA interference (RNAi) has great potential as a tool for studying gene function in mammals. However, the specificity and magnitude of the in vivo response to RNAi remains to be fully characterized. A molecular and phenotypic comparison of a genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3615dd64f1ae3cf5dd51b92e63d1ceab
https://doi.org/10.1093/nar/gkl609
https://doi.org/10.1093/nar/gkl609
Publikováno v:
Toxicological Sciences. 92:578-586
In rodents, treatment with peroxisome proliferator-activated receptor alpha (PPARalpha) agonists results in peroxisome proliferation, hepatocellular hypertrophy, and hepatomegaly. Drugs in the fibrate class of PPARalpha agonists have also been report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527c045dd00f7a0ea19a1b196ad28d13
https://doi.org/10.1093/toxsci/kfl019
https://doi.org/10.1093/toxsci/kfl019
Publikováno v:
Journal of Biological Chemistry. 274:24408-24416
The insulin-like growth factor II/mannose 6-phosphate receptor (IGF2R) carries out multiple regulatory and transport functions, and disruption of IGF2R function has been implicated as a mechanism to increase cell proliferation. Several missense IGF2R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996bbe8df9cde4a30621fc350cf74375
https://doi.org/10.1074/jbc.274.34.24408
https://doi.org/10.1074/jbc.274.34.24408
Autor:
Jonathan M. Mansbach, Jeremy Mills, Angus T. De Souza, Ivan J. Boyer, Gerald R. Hankins, Randy L. Jirtle
Publikováno v:
Carcinogenesis. 17:171-174
Phenobarbital (PB) is a potent tumor promoter in rodentliver. In this study we investigated whether PB selectivelypromotes a population of initiated cells with reduced levelsof transforming growth factor-P (TGFP) receptors types I,II and III. Liver t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73bcd4fa77da0197cd14995295c83bf1
https://doi.org/10.1093/carcin/17.1.171
https://doi.org/10.1093/carcin/17.1.171
Autor:
John C Rockett, Lawrence W Yoon, Roger G Ulrich, Hong A Ni, Robert A. Jolly, Valerie Baker, Angus T. De Souza, Colette M Duggan, Judith E Schmid, Helen M Harries, Jeff F Waring, Roger H Brown
Publikováno v:
Environmental Health Perspectives
Microarrays have the potential to significantly impact our ability to identify toxic hazards by the identification of mechanistically relevant markers of toxicity. To be useful for risk assessment, however, microarray data must be challenged to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c60d5d421eae043e28a6f00786abfe
https://doi.org/10.1289/txg.6677
https://doi.org/10.1289/txg.6677
Publikováno v:
Mutation research. 549(1-2)
Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptors whose ligands include fatty acids, eicosanoids and the fibrate class of drugs. In humans, fibrates are used to treat dyslipidemias. In rodents, fibrates cause peroxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87779b8e45cc17344b79994adb0344f4
https://pubmed.ncbi.nlm.nih.gov/15120967
https://pubmed.ncbi.nlm.nih.gov/15120967
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 94(19)
This report shows that loss of heterozygosity at the mannose 6-phosphate/insulin-like growth factor II receptor ( M6P/IGF2R ) locus occurred in 5/8 (63%) dysplastic liver lesions and 11/18 (61%) hepatocellular carcinomas (HCCs) associated with the hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2efa365f8020f2e218d67f917677d7b
https://pubmed.ncbi.nlm.nih.gov/9294214
https://pubmed.ncbi.nlm.nih.gov/9294214
Autor:
Roger G. Ulrich, David L. Lewis, Yudong D. He, Jim E Hagstrom, Andrew G Spencer, Peter S Linsley, Chang-kyu Lee, Hans Herweijer, Hongyue Dai, Xudong Dai, Angus T. De Souza, Douglas E Bassett
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 3, p e30 (2007)
PLoS Computational Biology
PLoS Computational Biology
Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc20773dd20a9fff09085a6ea3f3075a
https://doi.org/10.1371/journal.pcbi.0030030.eor
https://doi.org/10.1371/journal.pcbi.0030030.eor
Autor:
Angus T. De Souza
Publikováno v:
Toxicological Sciences; Aug2006, Vol. 92 Issue 2, p578-586, 9p