Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Angus N M Weir"'
Autor:
Ashley J. Winter, Matthew T. Rowe, Angus N. M. Weir, Nahida Akter, Sbusisiwe Z. Mbatha, Paul D. Walker, Christopher Williams, Zhongshu Song, Paul R. Race, Christine L. Willis, Matthew P. Crump
Publikováno v:
Winter, A J, Rowe, M T, Weir, A N M, Akter, N, Mbatha, S Z, Walker, P D, Williams, C, Song, Z, Race, P R, Willis, C L & Crump, M P 2022, ' Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin ', Angewandte Chemie-International Edition, vol. 61, no. 50, e202212393 . https://doi.org/10.1002/anie.202212393
Mupirocin is a clinically important antibiotic produced by Pseudomonas fluorescens NCIMB 10586 that is assembled by a complex trans-AT polyketide synthase. The polyketide fragment, monic acid, is esterified by a 9-hydroxynonanoic acid (9HN) side chai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f3287f7bbdf8f76bb39e10e426174f
https://pubmed.ncbi.nlm.nih.gov/36227272
https://pubmed.ncbi.nlm.nih.gov/36227272
Autor:
Jozef Anné, Eveline-Marie Lammens, Piet Herdewijn, Thomas Lathouwers, Matthew P. Crump, Michiel Vanmeert, Harry Cuppens, Joleen Masschelein, Ruben Degroote, Eveline Lescrinier, Ling-Jie Gao, Rob Lavigne, Angus N M Weir, Simone Kosol, Thomas J. Simpson, Kristof Vrancken, Christine L. Willis, Christopher D. Fage
Publikováno v:
Fage, C D, Lathouwers, T, Vanmeert, M, Gao, L-J, Vrancken, K, Lammens, E-M, Weir, A N M, Degroote, R, Cuppens, H, Kosol, S, Simpson, T J, Crump, M P, Willis, C L, Herdewijn, P, Lescrinier, E, Lavigne, R, Anné, J & Masschelein, J 2020, ' The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI ', Angewandte Chemie-International Edition, vol. 59, no. 26, pp. 10549-10556 . https://doi.org/10.1002/anie.201915407
The enoyl-acyl carrier protein reductase enzyme FabI is essential for fatty acid biosynthesis in Staphylococcus aureus and represents a promising target for the development of novel, urgently needed anti-staphylococcal agents. Here, we elucidate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c3714deeb6f24a44b0d654bb7f33bb
https://doi.org/10.1002/anie.201915407
https://doi.org/10.1002/anie.201915407
Autor:
Nahida Akter, Matthew T. Rowe, Ashley J. Winter, Christine L. Willis, Christopher Williams, Matthew P. Crump, Thomas J. Simpson, Paul R. Race, Zhongshu Song, Angus N M Weir, Luoyi Wang, Paul D. Walker
Publikováno v:
Walker, P D, Rowe, M T, Winter, A J, Weir, A N M, Akter, N, Wang, L, Race, P R, Williams, C, Song, Z, Simpson, T J, Willis, C L & Crump, M P 2020, ' A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis ', ACS Chemical Biology, vol. 2020 . https://doi.org/10.1021/acschembio.9b00969
Mupirocin, a commercially available antibiotic produced by Pseudomonas fluorescens NCIMB 10586, and thiomarinol, isolated from the marine bacterium Pseudoalteromonas sp. SANK 73390, both consist of a polyketide-derived monic acid homologue esterified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea14d9c93247b430f0a870296365c246
https://doi.org/10.1021/acschembio.9b00969
https://doi.org/10.1021/acschembio.9b00969
Control of β‐Branching in Kalimantacin Biosynthesis: Application of13C NMR to Polyketide Programming
Autor:
John Crosby, Luoyi Wang, Thomas J. Simpson, Angus N M Weir, Christopher Williams, Paul R. Race, Paul D. Walker, Christine L. Willis, Matthew P. Crump
Publikováno v:
Walker, P, Williams, C, Weir, A, Wang, L, Crosby, J, Race, P, Simpson, T, Willis, C & Crump, M 2019, ' Control of beta-Branching in Kalimantacin Biosynthesis : Application of 13C NMR to Polyketide Programming ', Angewandte Chemie, vol. 131, no. 36, pp. 12576-12580 . https://doi.org/10.1002/ange.201905482
The presence of beta‐branches in the structure of polyketides that possess potent biological activity underpins their widespread importance. Kalimantacin is a polyketide antibiotic with selective activity against staphylococci and its biosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa02e54f27765fa3db51b4dde32f79c
https://doi.org/10.1002/anie.201905482
https://doi.org/10.1002/anie.201905482
Publikováno v:
Natural product reports. 38(4)
Covering: 2008 to August 2020 Polyketides are a family of natural products constructed from simple building blocks to generate a diverse range of often complex chemical structures with biological activities of both pharmaceutical and agrochemical imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eceaa1de8cfeba1c3e1dc286f3bde0c
https://pubmed.ncbi.nlm.nih.gov/33057534
https://pubmed.ncbi.nlm.nih.gov/33057534
Autor:
Christine L. Willis, Jonathan A. Davies, Freya M. Bull, Joleen Masschelein, Angus N M Weir, Thomas J. Simpson, Matthew P. Crump, Paul D. Walker, Rob Lavigne, Paul R. Race
Publikováno v:
Davies, J A, Bull, F M, Walker, P D, Weir, A N M, Lavigne, R, Masschelein, J, Simpson, T J, Race, P R, Crump, M P & Willis, C L 2020, ' Total Synthesis of Kalimantacin A ', Organic Letters, vol. 22, no. 16, pp. 6349-6353 . https://doi.org/10.1021/acs.orglett.0c02190
The kalimantacins make up a family of hybrid polyketide-nonribosomal peptide-derived natural products that display potent and selective antibiotic activity against multidrug resistant strains of Staphylococcus aureus. Herein, we report the first tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cbb26d2dc084803a5469d0777a29f0
https://pubmed.ncbi.nlm.nih.gov/32806153
https://pubmed.ncbi.nlm.nih.gov/32806153
Autor:
Paul D, Walker, Christopher, Williams, Angus N M, Weir, Luoyi, Wang, John, Crosby, Paul R, Race, Thomas J, Simpson, Christine L, Willis, Matthew P, Crump
Publikováno v:
Angewandte Chemie (International ed. in English). 58(36)
The presence of β-branches in the structure of polyketides that possess potent biological activity underpins the widespread importance of this structural feature. Kalimantacin is a polyketide antibiotic with selective activity against staphylococci,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eddc7c634c3662c6e71583db01f83dd3
https://pubmed.ncbi.nlm.nih.gov/31294525
https://pubmed.ncbi.nlm.nih.gov/31294525