Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Angus M Tester"'
Autor:
Angus M Tester, Jennifer H Cox, Andrea R Connor, Amanda E Starr, Richard A Dean, Xose S Puente, Carlos López-Otín, Christopher M Overall
Publikováno v:
PLoS ONE, Vol 2, Iss 3, p e312 (2007)
We identify matrix metalloproteinase (MMP)-8, the polymorphonuclear (PMN) leukocyte collagenase, as a critical mediator initiating lipopolysaccharide (LPS)-responsiveness in vivo. PMN infiltration towards LPS is abrogated in Mmp8-null mice. MMP-8 cle
Externí odkaz:
https://doaj.org/article/43867c694e834ccb82d6c92d53dbe95f
Autor:
Eugenia Diaconu, Michelle Lin, J. Edwin Blalock, Eric Pearlman, Patricia L. Jackson, Angus M. Tester, Christopher M. Overall
Publikováno v:
The American Journal of Pathology. 173:144-153
Matrix metalloproteinase (MMP)-8 and MMP-9 play several roles in inflammation, including degradation of extracellular matrix (ECM) components and regulation of cytokine activity. To determine the roles of MMP-8 and MMP-9 in a neutrophil-dependent inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb72119a61661f3326cbae1235e6ad1
https://doi.org/10.2353/ajpath.2008.080081
https://doi.org/10.2353/ajpath.2008.080081
Autor:
Luca Mazzucchelli, Angus M. Tester, Christopher M. Overall, Marlene Wolf, Maddalena Lis, Lara Hasan, Mark Liebi, Robert E. Hunger
Publikováno v:
The Journal of Immunology. 176:6512-6522
Chemokine processing by proteases is emerging as an important regulatory mechanism of leukocyte functions and possibly also of cancer progression. We screened a large panel of chemokines for degradation by cathepsins B and D, two proteases involved i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a56730686b406bc7a1e0e0c38e7871
https://doi.org/10.4049/jimmunol.176.11.6512
https://doi.org/10.4049/jimmunol.176.11.6512
Autor:
Milagros Balbín, Alberto M. Pendás, Carlos López-Otín, Christopher M. Overall, Aurora Astudillo, Ana S. Pitiot, Steven D. Shapiro, Antonio Fueyo, Angus M. Tester
Publikováno v:
Nature Genetics. 35:252-257
Matrix metalloproteinases (MMPs) have fundamental roles in tumor progression, but most clinical trials with MMP inhibitors have not shown improvements in individuals with cancer. This may be partly because broad-range inhibitors also reduce host-prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e683d240639896e4e6e2862aa531743b
https://doi.org/10.1038/ng1249
https://doi.org/10.1038/ng1249
Publikováno v:
Clinical and Experimental Metastasis. 18:553-560
We have investigated the gelatinase profiles and invasiveness of clonal tumour sublines derived from a spontaneously arising mammary tumour in a Balb/cfC3H mouse. The 67NR. 66c14 and 4T1.2 sublines have low, intermediate and high metastatic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c0ae6ebf28fb0ab4060b5d4492c9ad2
https://doi.org/10.1023/a:1011953118186
https://doi.org/10.1023/a:1011953118186
Autor:
Christopher J. Handley, Wendy E. Cain, Gregory J. Checkley, Anne E. Cant, Ann D. Winter, Margaret A. Campbell, Geraldine L. Chow, Angus M. Tester
Publikováno v:
Archives of Biochemistry and Biophysics. 329:181-190
Bovine collateral ligament synthesized a 35S-labeled large proteoglycan species which eluted with a Kav of approximately 0.27 on Sepharose CL-2B and contained only chondroitin sulfate chains with a molecular mass of approximately 32 kDa. Fluorography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71c20f239fb1bd681bbc704a5c4b5be
https://doi.org/10.1006/abbi.1996.0207
https://doi.org/10.1006/abbi.1996.0207
Autor:
Xose S. Puente, Jennifer H. Cox, Richard A. Dean, Angus M. Tester, Christopher M. Overall, Andrea R. Connor, Amanda E. Starr, Carlos López-Otín
Publikováno v:
PLoS ONE
PLoS ONE, Vol 2, Iss 3, p e312 (2007)
PLoS ONE, Vol 2, Iss 3, p e312 (2007)
We identify matrix metalloproteinase (MMP)-8, the polymorphonuclear (PMN) leukocyte collagenase, as a critical mediator initiating lipopolysaccharide (LPS)-responsiveness in vivo. PMN infiltration towards LPS is abrogated in Mmp8-null mice. MMP-8 cle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c60b646fba0a39a0242c913ed4ecfc3
http://europepmc.org/articles/PMC1819564
http://europepmc.org/articles/PMC1819564
Autor:
Emma C. Walker, Mark Waltham, Marc E. Lippman, Erik W. Thompson, Margaret M. Bills, Angus M. Tester, Se Jeong Oh, Francis G. Kern, William G. Stetler-Stevenson, Seog Nyeon Bae
Publikováno v:
Cancer research. 64(2)
The ability to activate pro-matrix metalloproteinase (pro-MMP)-2 via membrane type-MMP is a hallmark of human breast cancer cell lines that show increased invasiveness, suggesting that MMP-2 contributes to human breast cancer progression. To investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0b50de94fab68e2a1f37aec5ab4b45
https://pubmed.ncbi.nlm.nih.gov/14744781
https://pubmed.ncbi.nlm.nih.gov/14744781
Publikováno v:
Clinicalexperimental metastasis. 19(5)
Orthotopic or intracardiac injection of human breast cancer cell lines into immunocompromised mice allows study of the molecular basis of breast cancer metastasis. We have established a quantitative real-time PCR approach to analyze metastatic spread
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cce4a998bbeaf6091f1dc66677578f03
https://pubmed.ncbi.nlm.nih.gov/12198765
https://pubmed.ncbi.nlm.nih.gov/12198765
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 18(1)
In explant cultures of articular cartilage from cattle of different ages radiolabeled leucine was shown to be incorporated into link proteins 1, 2 and 3. The newly synthesized link proteins were incorporated into and lost from the cartilage extracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e267338684f3d880aec1ec611b584c22
https://pubmed.ncbi.nlm.nih.gov/10367732
https://pubmed.ncbi.nlm.nih.gov/10367732