Výsledky vyhledávání - "Angus M MacNicol"

Akademický článek

The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs

Autor: Jewel Banik, Ana Rita Silva Moreira, Juchan Lim, Sophia Tomlinson, Linda L. Hardy, Alex Lagasse, Anessa Haney, Meghan R. Crimmins, Ulrich Boehm, Angela K. Odle, Melanie C. MacNicol, Gwen V. Childs, Angus M. MacNicol

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Abstract The pituitary functions as a master endocrine gland that secretes hormones critical for regulation of a wide variety of physiological processes including reproduction, growth, metabolism and stress responses. The distinct hormone-producing c

Externí odkaz: https://doaj.org/article/367dcc30f1c442de93a8c3febc716b13

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Akademický článek

Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements.

Autor: Charlotte E Rutledge, Ho-Tak Lau, Hazel Mangan, Linda L Hardy, Olaf Sunnotel, Fan Guo, Angus M MacNicol, Colum P Walsh, Diane J Lees-Murdock

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88385 (2014)

Regulation of DNMT1 is critical for epigenetic control of many genes and for genome stability. Using phylogenetic analysis we characterized a block of 27 nucleotides in the 3'UTR of Dnmt1 mRNA identical between humans and Xenopus and investigated the

Externí odkaz: https://doaj.org/article/ded1e919582a401c89d9eaa7a96e6861

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Akademický článek

Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer

Autor: Alicja Urbaniak, Megan R. Reed, Billie Heflin, John Gaydos, Sergio Piña-Oviedo, Marta Jędrzejczyk, Greta Klejborowska, Natalia Stępczyńska, Timothy C. Chambers, Alan J. Tackett, Analiz Rodriguez, Adam Huczyński, Robert L. Eoff, Angus M. MacNicol

Publikováno v: Biomedicine & Pharmacotherapy, Vol 153, Iss , Pp 113440- (2022)

Glioblastoma (GBM) remains the most frequently diagnosed primary malignant brain cancer in adults. Despite recent progress in understanding the biology of GBM, the clinical outcome for patients remains poor, with a median survival of approximately on

Externí odkaz: https://doaj.org/article/3ff41f2fa16c4f20a3d33e8d6d5030db

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Akademický článek

Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models

Autor: Alicja Urbaniak, Megan R. Reed, Daniel Fil, Anika Moorjani, Sarah Heflin, Michał Antoszczak, Michał Sulik, Adam Huczyński, Michalina Kupsik, Robert L. Eoff, Melanie C. MacNicol, Timothy C. Chambers, Angus M. MacNicol

Publikováno v: Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111815- (2021)

Breast cancer remains one of the leading cancers among women. Cancer stem cells (CSCs) are tumor-initiating cells which drive progression, metastasis, and reoccurrence of the disease. CSCs are resistant to conventional chemo- and radio-therapies and

Externí odkaz: https://doaj.org/article/8f0fa178769f44c6a5f9775fcc5dbcfa

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Akademický článek

410 Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge and Resistance in Male Offspring to a High Fat Diet

Autor: Tiffany K. Miles, Melody L. Allensworth, Ana Rita Silva Moreira, Angela K. Odle, Anessa Haney, Alexandra Lagasse, Angus M. MacNicol, Gwen V. Childs

Publikováno v: Journal of Clinical and Translational Science, Vol 6, Pp 79-79 (2022)

OBJECTIVES/GOALS: Maternal undernutrition, a form of malnutrition, can alter neonatal leptin signaling and result in metabolic dysfunction in adulthood. We developed a mild undernutrition model to relate more to societys nutritional challenges and to

Externí odkaz: https://doaj.org/article/d52dc189fc304e85b63bd8c695ca0821

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Akademický článek

Molecular Mechanisms of Pituitary Cell Plasticity

Autor: Gwen V. Childs, Angus M. MacNicol, Melanie C. MacNicol

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

The mechanisms that mediate plasticity in pituitary function have long been a subject of vigorous investigation. Early studies overcame technical barriers and challenged conceptual barriers to identify multipotential and multihormonal cell population

Externí odkaz: https://doaj.org/article/7a60480762554d2a92f38774b60a0424

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Akademický článek

Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction

Autor: Angela K. Odle, Melanie C. MacNicol, Gwen V. Childs, Angus M. MacNicol

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 7, p 3312 (2021)

The proper expression of gonadotropin-releasing hormone receptors (GnRHRs) by pituitary gonadotropes is critical for maintaining maximum reproductive capacity. GnRH receptor expression must be tightly regulated in order to maintain the normal pattern

Externí odkaz: https://doaj.org/article/e0d211d958b644f79fc339e83b9043e7

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