Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Angus C. Grey"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Application of stable isotopically labelled (SIL) molecules in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) over a series of time points allows the temporal and spatial dynamics of biochemical reactions t
Externí odkaz:
https://doaj.org/article/e9e9b65dc3ac4818bd65e6284766b85a
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
UV light is known to cause damage to biomolecules in living tissue. Tissues of the eye that play highly specialised roles in forming our sense of sight are uniquely exposed to light of all wavelengths. While these tissues have evolved protective mech
Externí odkaz:
https://doaj.org/article/63c878b44c5c4acba52b4ae3d202f46a
Autor:
Ali Zahraei, George Guo, Kyriakos G. Varnava, Nicholas J. Demarais, Paul J. Donaldson, Angus C. Grey
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Purpose: To spatially correlate the pattern of glucose uptake to glucose transporter distributions in cultured lenses and map glucose metabolism in different lens regions.Methods:Ex vivo bovine lenses were incubated in artificial aqueous humour conta
Externí odkaz:
https://doaj.org/article/5de547f2047048db9b6e27db8ba8d2dd
Autor:
Kathleen G. Mountjoy, Alexandre Caron, Kristina Hubbard, Avik Shome, Angus C. Grey, Bo Sun, Sarah Bould, Martin Middleditch, Beau Pontré, Ailsa McGregor, Paul W.R. Harris, Renata Kowalczyk, Margaret A. Brimble, Rikus Botha, Karen M.L. Tan, Sarah J. Piper, Christina Buchanan, Syann Lee, Anthony P. Coll, Joel K. Elmquist
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 207-216 (2018)
Objective: Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy bala
Externí odkaz:
https://doaj.org/article/97ac5cda40d14be9b1b3a08f94082f7b
Autor:
Anusha Balla, Seppo Auriola, Angus C. Grey, Nicholas J. Demarais, Annika Valtari, Emma M. Heikkinen, Elisa Toropainen, Arto Urtti, Kati-Sisko Vellonen, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 658 (2021)
Ocular drug absorption after eye drop instillation has been widely studied, but partitioning phenomena and spatial drug distribution are poorly understood. We investigated partitioning of seven beta-blocking drugs in corneal epithelium, corneal strom
Externí odkaz:
https://doaj.org/article/162eda48723a475a9751d6954d92caef
Autor:
Brigitte Heike Schwendel, Farhana R. Pinu, Erica Zarate, Kyung Whan Bang, Angus C. Grey, George Guo, Praju Vikas Anekal
Publikováno v:
Journal of Agricultural and Food Chemistry. 69:4918-4933
Previous commercial studies carried out in New Zealand showed that mechanical shaking significantly reduced the incidence of Botrytis cinerea infection in wine grapes. However, the reasons behind this reduction are not well understood. Here, we emplo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87806f386193ef503dfd67ba7b88f8a9
https://doi.org/10.1021/acs.jafc.1c00413
https://doi.org/10.1021/acs.jafc.1c00413
Publikováno v:
Analytical and Bioanalytical Chemistry. 413:2637-2653
Matrix-assisted laser desorption/ionisation-imaging mass spectrometry (MALDI-IMS) is now an established imaging modality with particular utility in the study of biological, biomedical and pathological processes. In the first instance, the use of stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811c9c190e87ed8efdd9d6de2a6a4b19
https://doi.org/10.1007/s00216-021-03189-8
https://doi.org/10.1007/s00216-021-03189-8
Publikováno v:
Clinical & Experimental Ophthalmology. 48:1031-1042
Ocular tissues possess a robust antioxidant defence system to minimize oxidative stress and preserve tissue structure and function. Glutathione (GSH) is a powerful antioxidant and in the lens exists at unusually high concentrations. However, with adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05907f58f06aa552c753e705c779428
https://doi.org/10.1111/ceo.13801
https://doi.org/10.1111/ceo.13801
Publikováno v:
Progress in Retinal and Eye Research. :101152
The lens is an important determinant of overall vision quality whose refractive and transparent properties change throughout life. Alterations to the refractive properties of the lens contribute to the process of emmetropisation in early childhood, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451c7ca1058ebd631904fd7d4b81a3f7
https://doi.org/10.1016/j.preteyeres.2022.101152
https://doi.org/10.1016/j.preteyeres.2022.101152
Publikováno v:
Experimental eye research. 212
Age related nuclear (ARN) cataracts in humans take years to form and so experimental models have been developed to mimic the process in animals as a means of better understanding the etiology of nuclear cataracts in humans. A major limitation with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d276ad018d11297fc9d0f7f8e03e051b
https://pubmed.ncbi.nlm.nih.gov/34648773
https://pubmed.ncbi.nlm.nih.gov/34648773