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Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.

Autor: Toledo-Sherman L; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Breccia P; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Cachope R; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Bate JR; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Angulo-Herrera I; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Wishart G; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Matthews KL; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Martin SL; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Cox HC; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., McAllister G; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Penrose SD; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Vater H; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Esmieu W; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Van de Poël A; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Van de Bospoort R; Charles River , Leiden 2333 CR , Netherlands., Strijbosch A; Charles River , Leiden 2333 CR , Netherlands., Lamers M; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Leonard P; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Jarvis RE; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Blackaby W; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Barnes K; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Eznarriaga M; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Dowler S; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Smith GD; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Fischer DF; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Lazari O; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Yates D; Charles River , Chesterford Research Park , Saffron Walden CB10 1XL , U.K., Rose M; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Jang SW; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Muñoz-Sanjuan I; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States., Dominguez C; CHDI Management/CHDI Foundation , 6080 Center Drive , Los Angeles , California 90045 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2019 Mar 28; Vol. 62 (6), pp. 2988-3008. Date of Electronic Publication: 2019 Mar 19.