Genetic landscape of the ACE2 coronavirus receptor

Autor: Yang, Z, MacDonald-Dunlop, E, Chen, J, Zhai, R, Li, T, Richmond, A, Klaric, L, Pirastu, N, Ning, Z, Zheng, C, Wang, Y, Huang, T, He, Y, Guo, H, Ying, K, Gustafsson, S, Prins, B, Ramisch, A, Dermitzakis, ET, Png, G, Eriksson, N, Haessler, J, Hu, X, Zanetti, D, Boutin, T, Hwang, S-J, Wheeler, E, Pietzner, M, Raffield, LM, Kalnapenkis, A, Peters, JE, Viñuela, A, Gilly, A, Elmståhl, S, Dedoussis, G, Petrie, JR, Polašek, O, Folkersen, L, Chen, Y, Yao, C, Võsa, U, Pairo-Castineira, E, Clohisey, S, Bretherick, AD, Rawlik, K, Esko, T, Enroth, S, Johansson, Å, Gyllensten, U, Langenberg, C, Levy, D, Hayward, C, Assimes, TL, Kooperberg, C, Manichaikul, AW, Siegbahn, A, Wallentin, L, Lind, L, Zeggini, E, Schwenk, JM, Butterworth, AS, Michaëlsson, K, Pawitan, Y, Joshi, PK, Baillie, JK, Mälarstig, A, Reiner, AP, Wilson, JF, Shen, X, GenOMICC Consortium and the IMI-DIRECT Consortium

Publikováno v: 2022, ' Genetic Landscape of the ACE2 Coronavirus Receptor ', Circulation, vol. 145, no. 18, pp. 1398-1411 . https://doi.org/10.1161/CIRCULATIONAHA.121.057888

Background: SARS-CoV-2, the causal agent of COVID-19, enters human cells using the ACE2 (angiotensin-converting enzyme 2) protein as a receptor. ACE2 is thus key to the infection and treatment of the coronavirus. ACE2 is highly expressed in the heart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0128f78af77cf151b26041b84787ced5
http://hdl.handle.net/10044/1/96467

Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients

Autor: Angela Genchi, Aurora Semerano, Ghil Schwarz, Beatrice Dell’Acqua, Giorgia Serena Gullotta, Michela Sampaolo, Enzo Boeri, Angelo Quattrini, Francesca Sanvito, Susanna Diamanti, Andrea Bergamaschi, Stefano Grassi, Paola Podini, Pietro Panni, Caterina Michelozzi, Franco Simionato, Francesco Scomazzoni, Paolo Remida, Luca Valvassori, Andrea Falini, Carlo Ferrarese, Patrik Michel, Guillaume Saliou, Steven Hajdu, Simone Beretta, Luisa Roveri, Massimo Filippi, Davide Strambo, Gianvito Martino, Marco Bacigaluppi

Publikováno v: Acta Neuropathologica Communications
Acta neuropathologica communications, vol. 10, no. 1, pp. 14
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-13 (2022)

Coronavirus disease 2019 (COVID-19) is associated with an increased risk of thrombotic events. Ischemic stroke in COVID-19 patients entails high severity and mortality rates. Here we aimed to analyze cerebral thrombi of COVID-19 patients with large v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f006ea1f12848d828feb76b14eed1

SARS-CoV-2, Cardiovascular Diseases, and Noncoding RNAs

Publikováno v: International Journal of Molecular Sciences. 22(22)

Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is characterized by important respiratory impairments frequently associated with severe cardiovascular damages. Moreover, patients with p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od________83::b60b8247caecf6d284cf1d046b5a4a00
https://cris.maastrichtuniversity.nl/en/publications/bdfe4a7b-a843-4878-8494-77557f93c12b

Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney

Autor: Maciej Tomaszewski, Louise M Burrell, Stephen Harrap, Damian Skrypnik, Eddie Cano-Gamez, Sean G. Byars, Adam Greenstein, Maciej Glyda, Anthony M. Heagerty, Michelle C. Maier, Priscilla R. Prestes, Andrzej Antczak, Fadi J. Charchar, Xiao Jiang, Joanna Zywiec, Andrew P. Morris, Matthew Denniff, Bernard Keavney, Gosia Trynka, David Scannali, Xiaoguang Xu, Paweł Bogdański, Adrian S. Woolf, Alicja Nazgiewicz, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, James Eales, Bryan Williams, Tomasz J. Guzik, Nilesh J. Samani, Robert Król, Sushant Saluja, Monika Szulińska

Publikováno v: Jiang, X, Eales, J M, Scannali, D, Nazgiewicz, A, Prestes, P, Maier, M, Denniff, M, Xu, X, Saluja, S, Cano-Gamez, E, Wystrychowski, W, Szulinska, M, Antczak, A, Byars, S, Skrypnik, D, Glyda, M, Król, R, Zywiec, J, Zukowska-Szczechowska, E, Burrell, L M, Woolf, A S, Greenstein, A, Bogdanski, P, Keavney, B, Morris, A P, Heagerty, A, Williams, B, Harrap, S B, Trynka, G, Samani, N J, Guzik, T J, Charchar, F J & Tomaszewski, M 2020, ' Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney ', European Heart Journal, vol. 41, no. 48, pp. 4580-4588 . https://doi.org/10.1093/eurheartj/ehaa794
Eur Heart J
European Heart Journal

Aims Angiotensin-converting enzyme 2 (ACE2) is the cellular entry point for severe acute respiratory syndrome coronavirus (SARS-CoV-2)—the cause of coronavirus disease 2019 (COVID-19). However, the effect of renin-angiotensin system (RAS)-inhibitio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481d135a224eaa582028c5e25333c9d8
http://www.scopus.com/inward/record.url?scp=85099324025&partnerID=8YFLogxK

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Autor: Christoph, Muus, Luecken , Malte D., Gökcen, Eraslan, Lisa, Sikkema, Avinash, Waghray, Graham, Heimberg, Yoshihiko, Kobayashi, Eeshit Dhaval Vaishnav, Ayshwarya, Subramanian, Christopher, Smillie, Jagadeesh, Karthik A., Elizabeth Thu Duong, Evgenij, Fiskin, Elena Torlai Triglia, Meshal, Ansari, Peiwen, Cai, Brian, Lin, Justin, Buchanan, Sijia, Chen, Jian, Shu, Haber, Adam L., Hattie, Chung, Montoro, Daniel T., Taylor, Adams, Hananeh, Aliee, Allon, Samuel J., Zaneta, Andrusivova, Ilias, Angelidis, Orr, Ashenberg, Kevin, Bassler, Christophe, Bécavin, Inbal, Benhar, Joseph, Bergenstråhle, Ludvig, Bergenstråhle, Liam, Bolt, Emelie, Braun, Bui, Linh T., Steven, Callori, Mark, Chaffin, Evgeny, Chichelnitskiy, Joshua, Chiou, Conlon, Thomas M., Cuoco, Michael S., Cuomo, Anna S. E., Marie, Deprez, Grant, Duclos, Denise, Fine, Fischer, David S., Shila, Ghazanfar, Astrid, Gillich, Bruno, Giotti, Joshua, Gould, Minzhe, Guo, Gutierrez, Austin J., Habermann, Arun C., Tyler, Harvey, Peng, He, Xiaomeng, Hou, Lijuan, Hu, Yan, Hu, Alok, Jaiswal, Lu, Ji, Peiyong, Jiang, Kapellos, Theodoros S., Kuo, Christin S., Ludvig, Larsson, Leney-Greene, Michael A., Kyungtae, Lim, Monika, Litviňuková, Ludwig, Leif S., Soeren, Lukassen, Wendy, Luo, Henrike, Maatz, Elo, Madissoon, Lira, Mamanova, Kasidet, Manakongtreecheep, Sylvie, Leroy, Mayr, Christoph H., Mbano, Ian M., Mcadams, Alexi M., Nabhan, Ahmad N., Nyquist, Sarah K., Lolita, Penland, Poirion, Olivier B., Sergio, Poli, Cancan, Qi, Rachel, Queen, Daniel, Reichart, Ivan, Rosas, Schupp, Jonas C., Shea, Conor V., Xingyi, Shi, Rahul, Sinha, Sit, Rene V., Kamil, Slowikowski, Michal, Slyper, Smith, Neal P., Alex, Sountoulidis, Maximilian, Strunz, Sullivan, Travis B., Dawei, Sun, Carlos, Talavera-López, Peng, Tan, Jessica, Tantivit, Travaglini, Kyle J., Tucker, Nathan R., Vernon, Katherine A., Wadsworth, Marc H., Julia, Waldman, Xiuting, Wang, Ke, Xu, Wenjun, Yan, William, Zhao, Ziegler, Carly G. K., The NHLBI LungMap Consortium, Zerti, Darin, The Human Cell Atlas Lung Biological Network

Publikováno v: Nature Medicine, 27(3), 546-559. Nature Publishing Group
Nat Med
Nature Medicine

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact across the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d839ca15b7936b81f584514e712504f3