Výsledky vyhledávání - "Angiotensin II Type 1 Receptor Blockers/pharmacology"

Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders

Autor: Pawel Namsolleck, Ulrike Muscha Steckelings, Ludovit Paulis, Thomas Unger, Chiara Recarti, Sébastien Foulquier

Publikováno v: Drugs, 76(1), 1-12. Adis International Ltd
Drugs
Paulis, L, Foulquier, S, Namsolleck, P, Recarti, C, Steckelings, U M & Unger, T 2016, ' Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders ', Drugs, vol. 76, no. 1, pp. 1-12 . https://doi.org/10.1007/s40265-015-0509-4

Cardiovascular and metabolic disorders, such as hypertension, insulin resistance, dyslipidemia or obesity are linked with chronic low-grade inflammation and dysregulation of the renin-angiotensin system (RAS). Consequently, RAS inhibition by ACE inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1092674c27f9fca8a51fdec6469c485
https://doi.org/10.1007/s40265-015-0509-4

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The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells

Autor: Pires, Paulo W, Ko, Eun-A, Pritchard, Harry A T, Rudokas, Michael, Yamasaki, Evan, Earley, Scott

Publikováno v: Pires, P W, Ko, E-A, Pritchard, H A T, Rudokas, M, Yamasaki, E & Earley, S 2017, ' The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells ', The Journal of physiology, vol. 595, no. 14, pp. 4735-4753 . https://doi.org/10.1113/JP274310

KEY POINTS: The angiotensin II receptor type 1b (AT1 Rb ) is the primary sensor of intraluminal pressure in cerebral arteries. Pressure or membrane-stretch induced stimulation of AT1 Rb activates the TRPM4 channel and results in inward transient cati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3818::29b71682c21906026aa08b2897ddba4f
https://doi.org/10.1113/JP274310

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Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes

Autor: Iwashita, M., Sakoda, H., Kushiyama, A., Fujishiro, M., Ohno, H., Nakatsu, Y., Fukushima, Toshiaki, Kumamoto, S., Tsuchiya, Y., Kikuchi, T., Kurihara, H., Akazawa, H., Komuro, I., Kamata, H., Nishimura, F., Asano, T.

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 302:E286-E296

Macrophages are integrated into adipose tissues and interact with adipocytes in obese subjects, thereby exacerbating adipose insulin resistance. This study aimed to elucidate the molecular mechanism underlying the insulin-sensitizing effect of the an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c623b6e9c6611ffecc56ac1917a1ad85
https://doi.org/10.1152/ajpendo.00324.2011

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Losartan, an angiotensin II type 1 receptor blocker, protects human islets from glucotoxicity through the phospholipase C pathway

Autor: Guillaume Vial, Domenico Bosco, Jennifer Rieusset, Fabien Van Coppenolle, Anne-Marie Madec, R. Cassel, Sylvie Ducreux, Aurelia Mesnier, Charles Thivolet, Karim Chikh, Marie-Agnès Chauvin, Séverine Dubois

Publikováno v: FASEB Journal, Vol. 27, No 12 (2013) pp. 5122-30

As shown in a large clinical prospective trial, inhibition of the renin-angiotensin system (RAS) can delay the onset of type 2 diabetes in high-risk individuals. We evaluated the beneficial effects of RAS inhibition on β-cell function under glucotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3098c905ed4c7623fc5a13dd2626d9f9
https://archive-ouverte.unige.ch/unige:34324

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The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases

Autor: Fraga-Silva, Rodrigo A, Da Silva, Danielle G, Montecucco, Fabrizio, Mach, François, Stergiopulos, Nikolaos, da Silva, Rafaela F, Santos, Robson A S

Publikováno v: Thrombosis and Haemostasis, Vol. 108, No 6 (2012) pp. 1089-1096

Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::f9f7de99d6f1b359b9e045c73ecdc854
https://archive-ouverte.unige.ch/unige:78604

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Involvement of angiotensin II in the remodeling induced by a chronic decrease in blood flow in rat mesenteric resistance arteries

Autor: Emilie Vessières, Céline Baron-Menguy, Odile Dumont, Anne-Laure Guihot, Jean-François Subra, Laurent Loufrani, Daniel Henrion, Bertrand Toutain, Maud Cousin, Marc-Antoine Custaud

Publikováno v: Hypertension Research
Hypertension Research, Nature Publishing Group, 2010, 33 (8), pp.857-866. ⟨10.1038/hr.2010.83⟩
Hypertension Research, 2010, 33 (8), pp.857-66. ⟨10.1038/hr.2010.83⟩

International audience; Blood flow reduction induces inward remodeling of resistance arteries (RAs). This remodeling occurs in ischemic diseases, diabetes and hypertension. Nonetheless, the effect of flow reduction per se, independent of the effect o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34ff36957cb1b9964c68b833e86d3e2
https://hal.archives-ouvertes.fr/hal-02510514

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An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension

Autor: Alexander M. Simon, Lucia Mazzolai, Paolo Meda, Gérard Waeber, Jacques-Antoine Haefliger, Florian Alonso, Nathalie Krattinger

Publikováno v: Cardiovascular Research, Vol. 87, No 1 (2010) pp. 166-176
Cardiovascular research
Cardiovascular Research
Cardiovascular Research, vol. 87, no. 1, pp. 166-176

AIMS: Connexins (Cxs) play a role in the contractility of the aorta wall. We investigated how connexins of the endothelial cells (ECs; Cx37, Cx40) and smooth muscle cells (SMCs; Cx43, Cx45) of the aorta change during renin-dependent and -independent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2159b771829834a6c21e840b17352b4
https://archive-ouverte.unige.ch/unige:20732

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Are the pleiotropic effects of telmisartan clinically relevant?

Autor: Rizos, C. V., Elisaf, M. S., Liberopoulos, E. N.

Hypertension is one of the major risk factors for cardiovascular disease. Angiotensin receptor blockers (ARBs) are a class of antihypertensive drugs with established efficacy and favorable safety profile. Telmisartan, a member of the ARB family, hold

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::e418175d32bf91422d9c2670260b1f36
http://olympias.lib.uoi.gr/jspui/handle/123456789/23724

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Update on therapeutic strategies to increase adiponectin function and secretion in metabolic syndrome

Autor: Fabrizio Montecucco, François Mach

Publikováno v: Diabetes, Obesity and Metabolism, Vol. 11, No 5 (2009) pp. 445-454

Changes in diagnostic criteria have impacted on the definition of the metabolic syndrome. The central aetiological importance of insulin resistance has lessened, while the role of other cardiovascular risk factors has progressively increased. Inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0badd56f60fe27e3a7318906fdec040
https://archive-ouverte.unige.ch/unige:19977

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Is the fixed-dose combination of telmisartan and hydrochlorothiazide a good approach to treat hypertension?

Autor: Maillard, M.P., Burnier, M.

Publikováno v: Vascular Health and Risk Management, vol. 3, no. 3, pp. 265-278

Blockade of the renin-angiotensin system with selective AT1 receptor antagonists is recognized as an effective mean to lower blood pressure in hypertensive patients. Among the class of AT1 receptor antagonists, telmisartan offers the advantage of a v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::df53bbc5a29367643169db9224d03c9f
https://serval.unil.ch/notice/serval:BIB_B6BBE5D04E31

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