Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Autor: Teresa Tusié-Luna, Svati H. Shah, Wen-Jane Lee, Amit Khera, Gonçalo R. Abecasis, Olle Melander, Alan R. Shuldiner, Connor A. Emdin, Kari Stefansson, Jesper Gromada, Andrew P. Morris, Lee-Ming Chuang, Omri Gottesman, Lars G. Fritsche, Pradeep Natarajan, Marju Orho-Melander, Daniel F. Gudbjartsson, Anubha Mahajan, Marylyn D. Ritchie, William E. Kraus, Tooraj Mirshahi, Colm O'Dushlaine, Jason Flannick, Nicholas J. Wareham, Anne Tybjærg-Hansen, Anders Berg Wulff, Rashmi B. Prasad, Aris Baras, Jonas B. Nielsen, Valgerdur Steinthorsdottir, Yii-Der Ida Chen, Jerome I. Rotter, Lukas Habegger, Samantha N. Fetterolf, David Altshuler, Om Prakash Dwivedi, Tanya M. Teslovich, Cristen J. Willer, Luca A. Lotta, Andrew J. Murphy, Joseph B. Leader, Cristopher V. Van Hout, Christopher D. Still, Ola Hansson, David Birtwell, Alexander Lopez, Daniel J. Rader, John D. Overton, Anthony Marcketta, Patrick Sulem, Peter N. Benotti, Jose C. Florez, Lydia Coulter Kwee, David J. Carey, Oddgeir L. Holmen, Kristian Hveem, Leif Groop, Sekar Kathiresan, Viktoria Gusarova, Unnur Thorsteinsdottir, Cassandra M. Hartle, Uyenlinh L. Mirshahi, H. Lester Kirchner, Shannon Bruse, Robert A. Scott, Michael F. Murray, Marketa Sjögren, Jeffrey G. Reid, Aeron Small, Børge G. Nordestgaard, Amr H. Wardeh, Chad M. Brummett, Mark I. McCarthy, Frederick E. Dewey, David H. Ledbetter, John Penn, Ingrid B. Borecki, Scott M. Damrauer, Hilma Holm, Michael Boehnke, George D. Yancopoulos

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W-J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L-M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y-D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, pp. 2252 . https://doi.org/10.1038/s41467-018-04611-z
Gusarova, V, O'Dushlaine, C, Teslovich, T M, Benotti, P N, Mirshahi, T, Gottesman, O, Van Hout, C V, Murray, M F, Mahajan, A, Nielsen, J B, Fritsche, L, Wulff, A B, Gudbjartsson, D F, Sjögren, M, Emdin, C A, Scott, R A, Lee, W J, Small, A, Kwee, L C, Dwivedi, O P, Prasad, R B, Bruse, S, Lopez, A E, Penn, J, Marcketta, A, Leader, J B, Still, C D, Kirchner, H L, Mirshahi, U L, Wardeh, A H, Hartle, C M, Habegger, L, Fetterolf, S N, Tusie-Luna, T, Morris, A P, Holm, H, Steinthorsdottir, V, Sulem, P, Thorsteinsdottir, U, Rotter, J I, Chuang, L M, Damrauer, S, Birtwell, D, Brummett, C M, Khera, A V, Natarajan, P, Orho-Melander, M, Flannick, J, Lotta, L A, Willer, C J, Holmen, O L, Ritchie, M D, Ledbetter, D H, Murphy, A J, Borecki, I B, Reid, J G, Overton, J D, Hansson, O, Groop, L, Shah, S H, Kraus, W E, Rader, D J, Chen, Y D I, Hveem, K, Wareham, N J, Kathiresan, S, Melander, O, Stefansson, K, Nordestgaard, B G, Tybjærg-Hansen, A, Abecasis, G R, Altshuler, D, Florez, J C, Boehnke, M, McCarthy, M I, Yancopoulos, G D, Carey, D J, Shuldiner, A R, Baras, A, Dewey, F E & Gromada, J 2018, ' Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes ', Nature Communications, vol. 9, no. 1, 2252 . https://doi.org/10.1038/s41467-018-04611-z
Nature Communications
Nature communications, vol 9, iss 1

Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve glucose homeostasis and d

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https://doaj.org/article/a3d832a109514250b3a42f9eaa1a1b95